Evaluating the Efficacy of Supervised Learning vs Large Language Models for Identifying Cognitive Distortions and Suicidal Risks in Chinese Social Media

Posted by klaurent Cornell

Kavli Affiliate: Dan Luo | First 5 Authors: Hongzhi Qi, Qing Zhao, Changwei Song, Wei Zhai, Dan Luo | Summary: Large language models, particularly those akin to the rapidly progressing GPT series, are gaining traction for their expansive influence. While there is keen interest in their applicability within medical domains such as psychology, tangible explorations […]


Continue.. Evaluating the Efficacy of Supervised Learning vs Large Language Models for Identifying Cognitive Distortions and Suicidal Risks in Chinese Social Media

Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Posted by klaurent Rockefeller

Kavli Affiliate: Alipasha Vaziri, Jeffrey M. Friedman | Authors: Bowen Tan, Caleb J Browne, Tobias Nobauer, Alipasha Vaziri, Jeffrey M. Friedman and Eric J. Nestler | Summary: Addiction prioritizes drug use over innate needs by hijacking brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron […]


Continue.. Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Jamil Mahmud, Brittany W Geiler, Juthi Biswas, Michael J Miller, Julia E Myers, Stephen M Matthews, Amanda B Wass, Christine M O’Connor and Gary C Chan | Summary: Establishing a non-productive quiescent/silent infection within monocytes is essential for spread of human cytomegalovirus (HCMV). Yet, how HCMV establishes a quiescent […]


Continue.. Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes

Reward expectation selectively boosts the firing of accumbens D1+ neurons during motivated approach

Posted by klaurent UCSF

Kavli Affiliate: Joshua Berke | Authors: Thomas Faust, Ali Mohebi and Joshua D Berke | Summary: The nucleus accumbens (NAc) helps govern motivation to pursue rewards. Two distinct sets of NAc projection neurons – expressing dopamine D1 versus D2 receptors – are thought to promote and suppress motivated behaviors respectively. However, support for this conceptual […]


Continue.. Reward expectation selectively boosts the firing of accumbens D1+ neurons during motivated approach

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Posted by klaurent Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich and Stephanie C Hicks | Summary: Norepinephrine (NE) neurons in the locus […]


Continue.. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Costs of resistance limit the effectiveness of cooperation enforcement

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Michael E Miller, Susan Sidell and Elizabeth A Ostrowski | Summary: Cooperative groups are susceptible to invasion by cheaters that reap the benefits but fail to pay the costs. Both theory and experimental work have shown that cheating can select for counter-adaptations to resist cheating. But then why is […]


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PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

Posted by klaurent UCSF

Kavli Affiliate: Bjoern Schwer | Authors: Christin Schmidt, Sarah Cohen, Brian L. Gudenas, Sarah Husain, Annika Carlson, Samantha Westelman, Linyu Wang, Joanna J. Phillips, Paul A. Northcott, William A. Weiss and Bjoern Schwer | Summary: SNCAIP duplication may promote Group 4 medulloblastoma via induction of PRDM6, a poorly characterized member of the PRDF1 and RIZ1 […]


Continue.. PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

Laws for Glia Organization Conserved Across Mammals

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Antonio Pinto-Duarte, Katharine Bogue, Terrence J. Sejnowski and Shyam Srinivasan | Summary: The organizational principles of glia remain largely unknown despite their vital role in nervous system function. Previous work has shown that the number of glia per unit volume of neocortex is constant across mammalian species. We hypothesize […]


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Causal Genetic Loci for a Motivated Behavior Spectrum Harbor Psychiatric Risk Genes

Posted by klaurent UCSF

Kavli Affiliate: Su Guo | Authors: Jiale Xu, Romelo Casanave, Apurva S Chitre, Qiyang Wang, Khai-Minh Nguyen, Chiara Blake, Mahendra Wagle, Riyan Cheng, Oksana Polesskaya, Abraham A Palmer and Su Guo | Summary: Behavioral diversity is critical for population fitness. Individual differences in risk-taking are observed across species, but underlying genetic mechanisms and conservation are […]


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Symmetry-resolved Entanglement Entropy, Spectra & Boundary Conformal Field Theory

Posted by dbos Tokyo

Kavli Affiliate: Hirosi Ooguri | First 5 Authors: Yuya Kusuki, Sara Murciano, Hirosi Ooguri, Sridip Pal, | Summary: We perform a comprehensive analysis of the symmetry-resolved (SR) entanglement entropy (EE) for one single interval in the ground state of a $1+1$D conformal field theory (CFT), that is invariant under an arbitrary finite or compact Lie […]


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