PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration

Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]


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The energetics of rapid cellular mechanotransduction

Kavli Affiliate: Michael Young | Authors: Michael N Young, Michael J Sindoni, Amanda H Lewis, Stefan Zauscher and Jorg Grandl | Summary: Cells throughout the human body detect mechanical forces. While it is known that the rapid (millisecond) detection of mechanical forces is mediated by force-gated ion channels, a detailed quantitative understanding of cells as […]


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Thalamus sends information about arousal but not valence to the amygdala

Kavli Affiliate: Kay Tye | Authors: Chris A Leppla, Laurel Keyes, Gordon Glober, Gillian A Matthews, Kanha Batra, Maya Jay, Yu Feng, Hannah S Chen, Fergil Mills, Jeremy Delahanty, Jake Olsen, Edward H Nieh, Praneeth Namburi, Craig Wildes, Romy Wichmann, Anna Beyelar, Eyal Y Kimchi and Kay M. Tye | Summary: Rationale The basolateral amygdala […]


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Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma

Kavli Affiliate: Denis Wirtz | Authors: Alexander T.F. Bell, Jacob T. Mitchell, Ashley L. Kiemen, Kohei Fujikura, Helen Fedor, Bonnie Gambichler, Atul Deshpande, Pei-Hsun Wu, Dimitrios N Sidiropoulos, Rossin Erbe, Jacob Stern, Rena Chan, Stephen Williams, James M. Chell, Jacquelyn W Zimmerman, Denis Wirtz, Elizabeth M. Jaffee, Laura D. Wood, Elana J. Fertig and Luciane […]


Continue.. Spatial transcriptomics of FFPE pancreatic intraepithelial neoplasias reveals cellular and molecular alterations of progression to pancreatic ductal carcinoma

Engineered Adhesion Molecules Drive Synapse Organization

Kavli Affiliate: Richard Huganir | Authors: William Dylan Hale, Thomas C. Sudhof and Richard L. Huganir | Summary: In multicellular organisms, cell-adhesion molecules connect cells into tissues and mediate intercellular signaling between these cells. In vertebrate brains, synaptic cell-adhesion molecules (SAMs) guide the formation, specification, and plasticity of synapses. Some SAMs, when overexpressed in cultured […]


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Gaia Spectroscopic Orbits Validated with LAMOST and GALAH Radial Velocities

Kavli Affiliate: Subo Dong | First 5 Authors: Dolev Bashi, Sahar Shahaf, Tsevi Mazeh, Simchon Faigler, Subo Dong | Summary: The recently published Gaia DR3 catalog of 181 327 spectroscopic binaries (SB) includes the Keplerian elements of each orbit, but not the measured radial velocities (RVs) and their epochs themselves. Instead, the catalog lists a […]


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Benchmarking quantum logic operations relative to thresholds for fault tolerance

Kavli Affiliate: Irfan Siddiqi | First 5 Authors: Akel Hashim, Stefan Seritan, Timothy Proctor, Kenneth Rudinger, Noah Goss | Summary: Contemporary methods for benchmarking noisy quantum processors typically measure average error rates or process infidelities. However, thresholds for fault-tolerant quantum error correction are given in terms of worst-case error rates — defined via the diamond […]


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Benchmarking quantum logic operations for achieving fault tolerance

Kavli Affiliate: Irfan Siddiqi | First 5 Authors: Akel Hashim, Stefan Seritan, Timothy Proctor, Kenneth Rudinger, Noah Goss | Summary: Contemporary methods for benchmarking noisy quantum processors typically measure average error rates or process infidelities. However, thresholds for fault-tolerant quantum error correction are given in terms of worst-case error rates — defined via the diamond […]


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Benchmarking verified logic operations for fault tolerance

Kavli Affiliate: Irfan Siddiqi | First 5 Authors: Akel Hashim, Stefan Seritan, Timothy Proctor, Kenneth Rudinger, Noah Goss | Summary: The promise of quantum computing depends upon the eventual achievement of fault-tolerant quantum error correction, which requires that the total rate of errors falls below some threshold. However, most contemporary methods for benchmarking noisy quantum […]


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Extracting Densest Sub-hypergraph with Convex Edge-weight Functions

Kavli Affiliate: Yi Zhou | First 5 Authors: Yi Zhou, Shan Hu, Zimo Sheng, , | Summary: The densest subgraph problem (DSG) aiming at finding an induced subgraph such that the average edge-weights of the subgraph is maximized, is a well-studied problem. However, when the input graph is a hypergraph, the existing notion of DSG […]


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