Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

Posted by klaurent Columbia

Kavli Affiliate: Wei Min | Authors: Daniel J.M. Crouch, Jamie R.J. Inshaw, Catherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Steven S. Rich and John A. Todd | Summary: For polygenic traits, associations with genetic variants can be detected over many chromosome regions, […]


Continue.. Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease

An Integrated Platform for High-Throughput Nanoscopy

Posted by klaurent Yale

Kavli Affiliate: Joerg Bewersdorf | Authors: Andrew E. S. Barentine, Yu Lin, Edward M Courvan, Phylicia Kidd, Miao Liu, Leonhard Balduf, Timy Phan, Felix Rivera-Molina, Michael R. Grace, Zach Marin, Mark Lessard, Juliana Rios-Chen, Siyuan Wang, Karla M Neugebauer, Joerg Bewersdorf and David Baddeley | Summary: Diffraction-unlimited single-molecule techniques like STORM and (F)PALM enable three-dimensional […]


Continue.. An Integrated Platform for High-Throughput Nanoscopy

Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Posted by klaurent Hopkins

Kavli Affiliate: Paul Greengard | Authors: Ana Milosevic, Lucian Medrihan, Margarete Knudsens, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa and Paul Greengard | Summary: The cholinergic interneurons (ChATs) of the nucleus accumbens (NAc) have a critical role in the activity of this region, specifically in the context of major depressive disorder. To […]


Continue.. Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Optical Atomic Clock aboard an Earth-orbiting Space Station (OACESS): Enhancing searches for physics beyond the standard model in space

Posted by klaurent Tokyo

Kavli Affiliate: Yevgeny Stadnik | First 5 Authors: Vladimir Schkolnik, Dmitry Budker, Oliver Fartmann, Victor Flambaum, Leo Hollberg | Summary: We present a concept for a high-precision optical atomic clock (OAC) operating on an Earth-orbiting space station. This pathfinder science mission will compare the space-based OAC with one or more ultra-stable terrestrial OACs to search […]


Continue.. Optical Atomic Clock aboard an Earth-orbiting Space Station (OACESS): Enhancing searches for physics beyond the standard model in space

Optical Atomic Clock aboard an Earth-orbiting Space Station (OACESS): Enhancing searches for physics beyond the standard model in space

Posted by klaurent Tokyo

Kavli Affiliate: Yevgeny Stadnik | First 5 Authors: Vladimir Schkolnik, Dmitry Budker, Oliver Fartmann, Victor Flambaum, Leo Hollberg | Summary: We present a concept for a high-precision optical atomic clock (OAC) operating on an Earth-orbiting space station. This pathfinder science mission will compare the space-based OAC with one or more ultra-stable terrestrial OACs to search […]


Continue.. Optical Atomic Clock aboard an Earth-orbiting Space Station (OACESS): Enhancing searches for physics beyond the standard model in space

Optical Atomic Clock aboard an Earth-orbiting Space Station (OACESS): Enhancing searches for physics beyond the standard model in space

Posted by klaurent Tokyo

Kavli Affiliate: Yevgeny Stadnik | First 5 Authors: Vladimir Schkolnik, Dmitry Budker, Oliver Fartmann, Victor Flambaum, Leo Hollberg | Summary: We present a concept for a high-precision optical atomic clock (OAC) operating on an Earth-orbiting space station. This pathfinder science mission will compare the space-based OAC with one or more ultra-stable terrestrial OACs to search […]


Continue.. Optical Atomic Clock aboard an Earth-orbiting Space Station (OACESS): Enhancing searches for physics beyond the standard model in space

Localizing narrow Fe K$α$ emission within bright AGN

Posted by klaurent Peking

Kavli Affiliate: Claudio Ricci | First 5 Authors: Carolina Andonie, Franz E. Bauer, Rosamaria Carraro, Patricia Arevalo, David M. Alexander | Summary: The 6.4 keV Fe Ka emission line is a ubiquitous feature in X-ray spectra of AGN, and its properties track the interaction between the variable primary X-ray continuum and the surrounding structure from […]


Continue.. Localizing narrow Fe K$α$ emission within bright AGN

The radio signal of PSR B0950+08 is detected over the whole pulse phase

Posted by klaurent Peking

Kavli Affiliate: Kejia Lee | First 5 Authors: Zhengli Wang, Jiguang Lu, Jinchen Jiang, Jie Lin, Kejia Lee | Summary: Pulsars, known as the "lighthouses" in the universe, are thought to emit periodic pulses with duty-cycle ~10%. In this report, the 160min-data of a nearby pulsar, PSR B0950+08, observed with the Five-hundred-meter Aperture Spherical radio […]


Continue.. The radio signal of PSR B0950+08 is detected over the whole pulse phase

Radio signal of PSR B0950+08 is detected over the whole phase

Posted by klaurent Peking

Kavli Affiliate: Kejia Lee | First 5 Authors: Zhengli Wang, Jiguang Lu, Jinchen Jiang, Jie Lin, Kejia Lee | Summary: Pulsars, known as the "lighthouses" in the universe, are thought to emit periodic pulses with duty-cycle ~10%. In this report, the 160,min-data of a nearby pulsar, PSR B0950+08, observed with the Five-hundred-meter Aperture Spherical radio […]


Continue.. Radio signal of PSR B0950+08 is detected over the whole phase

Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Victoria Paradise, Malavika Sabu, Joanna Bafia, Nyle A Sharif, Chi Nguyen, Rijuta Dhanraj Mukim, Kalin D Konrad-Vicario, Xiao Wang, Bianca T Corjuc, Jack Fu, Gabriella Maldonado, Jeffrey Ndubisi, Michael Strickland, Helen Figueroa, Douglas L Almeida, Bradley T Hyman, David M Holtzman, Tal Nuriel and Kapil V Ramachandran | […]


Continue.. Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregation