Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 […]


Continue.. Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

Birth cluster simulations of planetary systems with multiple super-Earths: initial conditions for white dwarf pollution drivers

Posted by klaurent Peking

Kavli Affiliate: Rainer Spurzem | First 5 Authors: Katja Stock, Dimitri Veras, Maxwell X. Cai, Rainer Spurzem, Simon Portegies Zwart | Summary: Previous investigations have revealed that eccentric super-Earths represent a class of planets which are particularly effective at transporting minor bodies towards white dwarfs and subsequently polluting their atmospheres with observable chemical signatures. However, […]


Continue.. Birth cluster simulations of planetary systems with multiple super-Earths: initial conditions for white dwarf pollution drivers

Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.

Posted by klaurent Columbia

Kavli Affiliate: Wei Min | Authors: Clark D Wells, Kevin Lange, Abigail F Thompson, Wei Min Xu, Sherry G Clendenon, John S Underwood, Peter Harris, Britney-Shea Herbert, James A. Glazier, Angela Wandinger-Ness and Robert L Bacallao | Summary: Despite substantial progress in identifying and understanding causative mutations in autosomal dominant polycystic kidney disease (ADPKD), little […]


Continue.. Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.

Synergistic effect of mutations in the Parkinson’s disease-linked proteins synaptojanin 1 and auxilin

Posted by klaurent Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically-enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and […]


Continue.. Synergistic effect of mutations in the Parkinson’s disease-linked proteins synaptojanin 1 and auxilin

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Guy Hindley, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Borge Holen, Thomas Bjella, Chun Chieh Fan, Torill Uelan, Srdjan Djurovic, Olav B Smeland, Oleksandr Frei, Anders Dale and Ole Andreassen | Summary: Personality and cognition are […]


Continue.. Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

Rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao, Margaret Herre | Authors: Krithika Venkataraman, Nadav Shai, Priyanka Lakhiani, Sarah Zylka, Jieqing Zhao, Margaret Herre, Joshua Zeng, Lauren A Neal, Henrik Molina, Li Zhao and Leslie B Vosshall | Summary: Female Aedes aegypti mosquitoes impose a severe global public health burden as vectors of multiple viral pathogens. Under optimal environmental […]


Continue.. Rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought

Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles, Seth Blackshaw, Richard Huganir, Patrick Kanold, Kristina Nielsen | Authors: Jonathan Ling, Alexei Bygrave, Clayton Santiago, Rogger Carmen, Vickie Trinh, Minzhong Yu, Yini Li, Jeong Han, Kamil Taneja, Ying Liu, Rochinelle Dongmo, Travis Babola, Patrick Parker, Lizhi Jiang, Patrick Leavey, Jennifer Smith, Rachel Vistein, Megan Gimmen, Benjamin Dubner, Patric Teodorescu, THEODOROS […]


Continue.. Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Machine-learning interatomic potential for molecular dynamics simulation of ferroelectric KNbO3 perovskite

Posted by klaurent Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Hao-Cheng Thong, XiaoYang Wang, Han Wang, Linfeng Zhang, Ke Wang | Summary: Ferroelectric perovskites have been ubiquitously applied in piezoelectric devices for decades, among which, eco-friendly lead-free (K,Na)NbO3-based materials have been recently demonstrated to be an excellent candidate for sustainable development. Molecular dynamics is a versatile theoretical […]


Continue.. Machine-learning interatomic potential for molecular dynamics simulation of ferroelectric KNbO3 perovskite

Pomeranchuk Effect and Tunable Quantum Phase Transitions in 3L-MoTe2/WSe2

Posted by klaurent UCAS

Kavli Affiliate: Zheng Zhu | First 5 Authors: Mingjie Zhang, Xuan Zhao, Kenji Watanabe, Takashi Taniguchi, Zheng Zhu | Summary: Many sought-after exotic states of matter are known to emerge close to quantum phase transitions, such as quantum spin liquids (QSL) and unconventional superconductivity. It is thus desirable to experimentally explore systems that can be […]


Continue.. Pomeranchuk Effect and Tunable Quantum Phase Transitions in 3L-MoTe2/WSe2

Pomeranchuk Effect and Tunable Quantum Phase Transitions in 3L-MoTe2/WSe2

Posted by klaurent UCAS

Kavli Affiliate: Zheng Zhu | First 5 Authors: Mingjie Zhang, Xuan Zhao, Kenji Watanabe, Takashi Taniguchi, Zheng Zhu | Summary: Many sought-after exotic states of matter are known to emerge close to quantum phase transitions, such as quantum spin liquids (QSL) and unconventional superconductivity. It is thus desirable to experimentally explore systems that can be […]


Continue.. Pomeranchuk Effect and Tunable Quantum Phase Transitions in 3L-MoTe2/WSe2