This Week: Neuroscience – Kavli Institute Pre-Print Publications

Neuroticism Heterogeneity Through Item-Level Associations in Resting-State Functional Connectivity

Posted by dbos May 27, 2025May 28, 2025This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Masaya Misaki, Chun Chieh Fan, Wesley K Thompson, Heekyeong Park, Bohan Xu and Martin M Paulus | Summary: Neuroticism is characterized by emotional instability and increased susceptibility to stress-related disorders. While traditionally treated as a unitary construct, growing evidence suggests that neuroticism is heterogeneous in both its genetic basis […]

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Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease

Posted by dbos May 26, 2025May 28, 2025Rockefeller, This Week: Neuroscience

Kavli Affiliate: Nathaniel Heintz | Authors: Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Maria Esterlita Siantoputri, Hasnahana Chetia, Yurie Harada, Erika Sipos, Paul Darnell, Laura Kus, Thomas Carroll, Douglas Barrows, Christina Pressl, Nicholas Didkovsky and Nathaniel Heintz | Summary: Huntington’s disease (HD) is characterized by neuronal dysfunction and degeneration that varies markedly by brain region and […]

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Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation

Posted by dbos May 24, 2025May 28, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Edward Chang | Authors: Youssef E Sibih, Abraham O Dada, Emily E Cunningham, Niels Olshausen, Jasleen Kaur, Velmurugan Jayabal, Sena Oten, Sanjeev Herr, Cesar N Gonzales, Andy Daniel, Saritha Krishna, Vardhaan S Ambati, Alexander A Aabedi, Gray Umbach, Kanish Mirchia, Poortata Lalwani, Edward F Chang, David R Raleigh, Srikantan Nagarajan, David Brang and […]

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The shape of attention: How cognitive goals sculpt cortical representation of speech.

Posted by dbos May 23, 2025May 28, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Mounya Elhilali | Authors: Moïra-Phoebé Huet and Mounya Elhilali | Summary: Perception requires more than passive sensing—it involves prioritizing the features most relevant to ongoing cognitive goals, a process guided by selective attention. A central question is whether attention operates by enhancing all features of a selected target, or by optimizing neural encoding […]

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Hebb’s Vision: The Structural Underpinnings of Hebbian Assemblie

Posted by dbos May 23, 2025May 28, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Reza Abbasi Asl | Authors: Julian A Wagner-Carena, Sai Kate, Trevor Riordan, Reza Abbasi-Asl, Joe Aman, Adam Amster, Agnes L Bodor, Derrick Brittain, JoAnn Buchanan, Michael A Buice, Daniel J Bumbarger, Forrest Collman, Nuno Macarico da Costa, Daniel J Denman, Saskia EJ de Vries, Emily Joyce, Dan Kapner, Chase W King, Josh D […]

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GABAergic signaling by VIP interneurons gates running-dependent visual recovery in the adult brain

Posted by dbos May 23, 2025May 28, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Michael Stryker | Authors: Anna Lebedeva, Friedrich Kling, Benjamin Rakela, Michael P Stryker and Yujiao Jennifer Sun | Summary: Experience-dependent plasticity in the adult visual cortex is enhanced by locomotion, a process mediated by vasoactive intestinal peptide (VIP)-expressing interneurons. While VIP interneurons are known to signal through both Gamma-aminobutyric acid (GABA) and VIP […]

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Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Miller | Authors: P Monroe Butler, Anna Francis, Angela L Meunier, Amirah K Anderson, Elizabeth L Hennessey, Michael B Miller, Cynthia A Lemere, Dennis J Selkoe and Andrew M Stern | Summary: Importance Anti-amyloid immunotherapy is used to treat Alzheimer disease (AD) with moderate benefits and potentially serious side effects due to […]

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Shared and distinct cortical mechanisms for working memory and decision-making.

Posted by dbos May 21, 2025May 28, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Daeyeol Lee | Authors: Hyojung Seo, Daeyeol Lee and Shanna K Murray | Summary: The dorsolateral prefrontal cortex (DLPFC) and lateral intraparietal cortex (LIP) in the primate brain are critically involved in working memory during tasks that require the retention of information over a delay. These same regions have also been implicated in […]

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Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice

Posted by dbos May 21, 2025May 28, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Alexandra Nelson | Authors: Rodrigo M Paz, Michael B Ryan, Pamela F Marcott, Allison E Girasole, Joseph Faryean, Vincent Duong, Sadhana Sridhar and Alexandra B Nelson | Summary: The use of levodopa to manage Parkinson’s disease (PD) symptoms leads to levodopa-induced dyskinesia (LID) and other motor fluctuations, which worsen with disease progression and […]

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Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging

Posted by dbos May 20, 2025May 28, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Miller | Authors: Maria Luisa Amaral, Sainath Mamde, Michael Miller, Xiaomeng Hou, Jessica Arzavala, Julia Osteen, Elizabeth Walker Smoot, Qian Yang, Emily Eisner, Qiurui Zeng, Cindy Tatiana Baez-Becerra, Jacqueline Olness, Joseph Colin Kern, Jonathan Rink, Nicholas Johnson, Ariana Barcoma, Silvia Cho, Stella Cao, Nora Emerson, Jasper Lee, Jackson Willier, Timothy Loe, Henry […]

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