This Week: Neuroscience – Kavli Institute Pre-Print Publications

Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

Posted by dbos August 10, 2025August 12, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Carlos Johnson-Cruz, Kathleen K.A. Cho and Vikaas S. Sohal | Summary: The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it critical to understand how the dynamic updating vs. stable maintenance of different encodings contribute to behavioral adaptation. We addressed this […]

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Causal Dynamics of Social Gaze in Primate Prefrontal-Amygdala Networks Revealed by Dynamic Bayesian Modeling

Posted by dbos August 10, 2025August 12, 2025This Week: Neuroscience, Yale

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Siqi Fan, Olga Dal Monte, Monika Jadi, Steve Chang and Anirvan Nandy | Summary: Social gaze is a fundamental channel of primate communication, shaping dynamic interactions and fostering mutual understanding. While prior studies have mapped the behavioral correlates of social gaze across the prefrontal-amygdala circuits, the causal […]

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A Scalable Toolkit for Modeling 3D Surface-based Brain Geometry

Posted by dbos August 9, 2025August 12, 2025This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Anders Dale and Lisa T. Eyler | Authors: Yanghee Im, Leila Nabulsi, Melody J.Y. Kang, Sophia I. Thomopoulos, Ana M. Diaz Zuluaga, Anders M. Dale, Andriana Karuk, Annabella Di Giorgio, Benson Mwangi, Boris Gutman, Bronwyn Overs, Carlos Lopez Jaramillo, Colm McDonald, Dan Stein, Dara M. Cannon, David Glahn, Diego Hidalgo-Mazzei, Diliana Pecheva, Dominik […]

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Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex

Posted by dbos August 9, 2025August 12, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Alex Kolodkin and Solange Brown | Authors: Alan Y. Gutman-Wei, Sriram Sudarsanam, Alec G. Cabalinan, Naseer Shahid, Anny Shi, Luis E. Guzman Clavel, Sophia M. Spindler-Krage, Amit Agarwal, Alex L. Kolodkin and Solange P. Brown | Summary: The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased […]

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StCEL-based platform enables detection and sequencing of native sialoglycoRNA

Posted by dbos August 8, 2025August 12, 2025Columbia, This Week: Neuroscience

Kavli Affiliate: Wei Min | Authors: Guang-Dong Zeng, Yun-Long Wang, Xu-Hui Chen, Yi Ma, Zhu Zhu, Huan-Lei Liu, Li-Yuan Fan, Hao Nan, Ziwaregul Nur, Min Wei, Xin-Yuan Liu, Li Yi, Jiu-Yu Jin, Yu-Song Cao, Meng-Bo Qiu, Wei-Peng Sun, Yang Bai, Quan-Bo Zhou, Guo-Qing Zhang, Jing-Feng Chen, Jie Shi, Jian Zheng, Yixuan Xie, Peng Li, Xiang-Bo […]

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Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiation

Posted by dbos August 7, 2025August 11, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Michael Beer | Authors: Jielin Yan, Hyein S. Cho, Renhe Luo, Michael A. Beer, Wei Li and Danwei Huangfu | Summary: Precise regulation of transcription factor (TF) expression is critical for maintaining cell identity, but studies on how graded expression levels affect cellular phenotypes are limited. To address this gap, we employed human […]

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CK2 inhibition suppresses glial inflammation in the brain

Posted by dbos August 7, 2025August 11, 2025This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: Fred H Gage, Ioana I N Da Silva, Desiree Ramirez, Sarah L Parylak, Leslie A Wallace, James K Tucker, Joel M Erberich, Rutvi Katariya, Aidan H McDonald, Iryna S Gallina, Ariana L Tucker, Jillybeth Burgado, Baptiste N Jaeger, Jerika J Barron, Joshua M Pratt, Monique Pena, Vipula Racha, Christina […]

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Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

Posted by dbos August 7, 2025August 11, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Aarron Justin Phensy, Lara Louise Hagopian, Caitriona M. Costello, Simon Haziza, Omkar Ghenand, Yanping Zhang, Mark J. Schnitzer and Vikaas Singh Sohal | Summary: Cognitive dysfunction in conditions such as schizophrenia involves disrupted communication between the prefrontal cortex (PFC) and mediodorsal thalamus (MD). Parvalbumin interneurons (PVI) are known to […]

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Protein Structure Informed Bacteriophage Genome Annotation with Phold

Posted by dbos August 6, 2025August 11, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Robert Edwards | Authors: George Bouras, Susanna R Grigson, Milot Mirdita, Michael Heinzinger, Bhavya Papudeshi, Vijini Mallawaarachchi, Renee Green, Rachel Seongeun Kim, Victor Mihalia, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde, Martin Steinegger and Robert A Edwards | Summary: Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for […]

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Modeling hidden cognitive states reveals acute and chronic effects of fentanyl on decision-making

Posted by dbos August 5, 2025August 11, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Patricia Janak | Authors: Zhenlong Zhang, Patricia H. Janak and Eric Garr | Summary: The cognitive mechanisms underlying behavior are often dynamic, shifting gradually or abruptly over time scales spanning years, to weeks, to minutes. Whether drug-induced changes in learning and decision-making follow similarly dynamic patterns remains unclear. To address this, we apply […]

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