This Week: Neuroscience – Kavli Institute Pre-Print Publications

mGluR4-Npdc1 complex mediates α-synuclein fibril-induced neurodegeneration

Posted by klaurent July 23, 2025July 23, 2025This Week: Neuroscience, Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Azucena Perez-Canamas, Mingming Chen, Leire Almandoz-Gil, Nabab Khan, Si Jie Tang, Allyson Ho, Erik C Gunther and Stephen M. Strittmatter | Summary: Fibrils of misfolded α-synuclein (α-syn) accumulate in Parkinson’s disease and other synucleinopathies, spreading between cells to template further misfolding and drive neurodegeneration. α-syn fibril entry into healthy […]

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Fold first, ask later: structure-informed function annotation of Pseudomonas phage proteins

Posted by dbos July 20, 2025July 23, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Robert Edwards | Authors: Hannelore Longin, George Bouras, Susanna R. Grigson, Robert A. Edwards, Hanne Hendrix, Rob Lavigne and Vera van Noort | Summary: Phages, the viruses of bacteria, harbor an incredibly diverse repertoire of proteins capable of manipulating their bacterial hosts, inspiring many medical and biotechnological applications. However, to date, only a […]

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Dynamic convergence of autism disorder risk genes across neurodevelopment

Posted by dbos July 19, 2025July 23, 2025This Week: Neuroscience, Yale

Kavli Affiliate: Vikaas Sohal | Authors: Cesar P Canales, Stephanie A Lozano, Nicholas A Frost, Karol Cichewicz, Wellington Amaral, Nicolas Seban, Ethan Fenton, Ayanna Wade, Nickolas Chu, Emily Smith, Cory Ardekani, Samuel Frank, Jeffrey Bennett, Pierre Lavenex, Aspen Kopley-Smith, Darlene Rahbarian, Melisa Corea, Daniela Perla, Liam Davis, Jiyuan Zhu, Rebecca Ortiz, Paris Beauregard, Sarah Morse, […]

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Genetically encoded assembly recorder temporally resolves cellular histories in cellulo and in vivo

Posted by dbos July 18, 2025July 23, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Dwight Bergles | Authors: Yuqing Yan, Jiaxi Lu, Zhe Li, Zuo-Han Zhao, Timothy F. Shay, Shunzhi Wang, Yaping Lei, Yimei Wang, Wei Chen, Patrick Parker, Hongru Yang, Aileen Qi, Yongzhi Sun, Dwight Bergles, David Baker and Dingchang Lin | Summary: Mapping cellular activity with high spatiotemporal precision in complex tissues is essential for […]

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A Rational Information Gathering Account of Infant Habituation

Posted by dbos July 18, 2025July 23, 2025This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Gili Karni, Marcelo Mattar, Lauren Emberson and Nathaniel Douglass Daw | Summary: Gaze is one of the primary experimental measures for studying cognitive development, especially in preverbal infants. However, the field is only beginning to develop a principled explanatory framework for making sense of the various factors affecting gaze. […]

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Complementary cortical and thalamic contributions to cell-type-specific striatal activity dynamics during movement

Posted by dbos July 18, 2025July 23, 2025This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Takaki Komiyama | Authors: Enida Gjoni, Ram Dyuthi Sristi, Haixin Liu, Shahar Dror, Xinlei Lin, Keelin O’Neil, Oscar M Arroyo, Sun Woo Hong, Hannah Kim, Jeffrey Liu, Sonja Blumenstock, Byungkook Lim, Gal Mishne and Takaki Komiyama | Summary: Coordinated motor behavior emerges from information flow across brain regions. How long-range inputs drive cell-type-specific […]

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Pak, a downstream gene of ecdysone signaling, determines left-right polarity in the Drosophila brain through neuronal cell chirality

Posted by dbos July 18, 2025July 23, 2025This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Ann-Shyn Chiang | Authors: So Sakamura, Komomo Suyama, Akari Tsujita, Fu-yu Hsu, Atsushi Tamada, Tomoyuki Miyashita, Minoru Saitoe, Ann-Shyn Chiang, Mikiko Inaki and Kenji Matsuno | Summary: Left-right (LR) asymmetry is a conserved characteristic of the brain in various animals and is related to its higher-order functions. The Drosophila brain has an LR […]

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Non-visual light modulates behavioral memory and gene expression in C. elegans

Posted by dbos July 16, 2025July 23, 2025This Week: Neuroscience, UCSF

Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]

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Statistically valid explainable black-box machine learning: applications in sex classification across species using brain imaging

Posted by dbos July 16, 2025July 23, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Joshua Vogelstein | Authors: Tingshan Liu, Jayanta Dey, Beiya Xu, Samuel S Alldritt, Karl-Heinz Nenning, Kyoungseob Byeon, Ting Xu and Joshua T. Vogelstein | Summary: Sex classification using neuroimaging data has the potential to revolutionize personalized diagnostics by revealing subtle structural brain differences that underlie sex-specific disease risks. Despite the promise of machine […]

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Cell type-specific barcoding reveals the projectional architecture of the mouse midbrain dopaminergic system

Posted by dbos July 15, 2025July 23, 2025Hopkins, This Week: Neuroscience

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Cheng Xu, Craig Washington, Maggie Lowman and Justus M Kebschull | Summary: Brain-wide neural circuits are formed by the diverse axonal branching patterns of many individual neurons. Here we introduce POlNTseq (projections of interest by sequencing), a high-throughput and user-friendly barcoded connectomics method that uses cell […]

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