Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Bart A Eijkelkamp, Timothy R Cavagnaro, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Garth Harmsworth, Damien J Keating, Robert A Edwards and Martin F Breed | Summary: The global rise in human allergic and autoimmune diseases is linked to altered environmental microbiome exposures from increasing […]


Continue.. Degraded ecosystem soil and type 2 diabetes gut microbiomes share altered potential metabolism for sugars, lignin and branched-chain fatty acids: a blind spot for global health?

Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]


Continue.. Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model

Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Li Zhao | Authors: Yuan-Fei Pan, Yong He, Yu-Qi Liu, Yong-Tao Shan, Shu-Ning Liu, Xue Liu, Xiaoyun Pan, Yinqi Bai, Zan Xu, Zheng Wang, Jieping Ye, Edward C. Holmes, Bo Li, Yao-Qing Chen, Zhao-Rong Li and Mang Shi | Summary: Predicting the evolution and function of viruses is a fundamental biological challenge, largely […]


Continue.. Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus

A genetic driver of epileptic encephalopathy impairs gating of synaptic glycolysis

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Timothy A. Ryan | Authors: Zhanat Koshenov, Alexandros C. Kokotos, Lorena Benedetti, Jennifer Lippincott Schwartz and Timothy A. Ryan | Summary: The brain is a disproportionately large consumer of fuel, estimated to expend ∼20% of the whole-body energy budget, and therefore it is critical to adequately control brain fuel expenditures while satisfying its […]


Continue.. A genetic driver of epileptic encephalopathy impairs gating of synaptic glycolysis

Deep Learning Improves Parameter Estimation in Reinforcement Learning Models

Posted by dbos This Week: Neuroscience, UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Hua-Dong Xiong, Li Ji-An, Marcelo G Mattar and Robert C Wilson | Summary: Cognitive modeling in psychology and neuroscience provides a formal approach to formulate and test hypotheses of cognitive processes. Such models rely on cognitive parameters that are intended to represent interpretable and identifiable psychological constructs. However, accurately […]


Continue.. Deep Learning Improves Parameter Estimation in Reinforcement Learning Models