Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Kavli Affiliate: Seth Blackshaw | Authors: Kurt Weir, Pin Lyu, Sangeetha Kandoi, Roujin An, Nicole Pannullo, Isabella Palazzo, Jared Tangeman, Jun Shi, Steven DeVries, Dana Merriman, Jiang Qian and Seth Blackshaw | Summary: Evolutionary adaptation to diurnal vision in ground squirrels has led to the development of a cone-dominant retina, in stark contrast to the […]


Continue.. Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels.

Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Kavli Affiliate: Alex Pollen | Authors: Sara Nolbrant, Jenelle L. Wallace, Jingwen Ding, Tianjia Zhu, Jess L. Sevetson, Janko Kajtez, Isabella A. Baldacci, Emily K. Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T. Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J. Pavlovic, Sofie R. Salama, Agnete Kirkeby, Hao Huang, Nathan K. Schaefer and Alex A. […]


Continue.. Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability

Tissue-specific clonal selection and differentiation of CD4+ T cells during infection

Kavli Affiliate: Daniel Mucida | Authors: Roham Parsa, Helder Carvalho de Assis, Tiago B.R. de Castro, Gabriella Lima dos Reis, Harald Hartweger, Angelina Bilate and Daniel Mucida | Summary: Pathogen-specific CD4⁺ T cells undergo dynamic expansion and contraction during infection, ultimately generating memory clones that shape the subsequent immune responses. However, the influence of distinct […]


Continue.. Tissue-specific clonal selection and differentiation of CD4+ T cells during infection

Robust representation and non-linear spectral integration of simple and complex harmonic sounds in layers 4 and 2/3 of primary auditory cortex

Kavli Affiliate: Patrick Kanold | Authors: Yunru Chen, Chih-Ting Chen, Yuhan Gui and Patrick O Kanold | Summary: Sound harmonicity is foundational in complex auditory stimuli like music and vocalizations but it remains unclear how such spectrally complex stimuli are processed in the auditory cortex (ACtx). Subregions of the auditory cortex process are thought to […]


Continue.. Robust representation and non-linear spectral integration of simple and complex harmonic sounds in layers 4 and 2/3 of primary auditory cortex

Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Kavli Affiliate: Attila Losonczy | Authors: Stephanie A Herrlinger, Jiayao Wang, Bovey Y Rao, Jonathan Chang, Joseph Gogos, Attila Losonczy and Dennis Vitkup | Summary: Neuropsychiatric disorders such as autism spectrum disorder (ASD) and schizophrenia (SCZ) share genetic risk factors, including rare high penetrance single nucleotide variants and copy number variants (CNVs), and exhibit both […]


Continue.. Rare mutations implicate CGE interneurons as a vulnerable axis of cognitive deficits across psychiatric disorders

Sensorimotor dynamics in the superior colliculus of the echolocating bat

Kavli Affiliate: Cynthia F. Moss | Authors: Gowri Somasekhar, Ninad B Kothari, Cynthia F Moss and Melville Wohlgemuth | Summary: To successfully execute natural tasks, animals must continuously monitor and integrate dynamic sensory information to guide behavior. While this process – known as active sensing – is fundamental to goal-directed behavior, the mechanisms by which […]


Continue.. Sensorimotor dynamics in the superior colliculus of the echolocating bat

2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

Kavli Affiliate: Attila Losonczy | Authors: Jingcheng Shi, Boaz Nutkovich, Dahlia Kushinsky, Bovey Y Rao, Stephanie A Herrlinger, Tiberiu S Mihaila, Katayun Cohen-Kashi Malina, Cliodhna K OToole, Margaret E Conde Paredes, Hyun C Yong, Erdem Varol, Attila Losonczy and Ivo Spiegel | Summary: Neural circuits are characterized by genetically and functionally diverse cell types. A […]


Continue.. 2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

Dynamic neural states underpin bradykinesia severity in Parkinsons disease

Kavli Affiliate: Philip Starr | Authors: Abhinav Sharma, Bahman Abdi Sargezeh, Amelia Hahn, Maria Shcherbakova, Wolf Julian Neumann, Simon Little, Philip Starr and Ashwini Oswal | Summary: Background: Bradykinesia in Parkinson′s disease (PD) may arise due to transient, network–wide neural dynamics that extend beyond beta–band oscillatory activity within the motor cortical-subthalamic nucleus (STN) circuit. Methods: […]


Continue.. Dynamic neural states underpin bradykinesia severity in Parkinsons disease

Facial gestures are enacted via a cortical hierarchy of dynamic and stable codes

Kavli Affiliate: Winrich Freiwald | Authors: Geena R Ianni, Yuriria Vazquez, Adam G Rouse, Marc Schieber, Yifat Prut and Winrich Freiwald | Summary: Successful communication requires the generation and perception of a shared set of signals. Facial gestures are one fundamental set of communicative behaviors in primates, generated through the dynamic arrangement of dozens of […]


Continue.. Facial gestures are enacted via a cortical hierarchy of dynamic and stable codes

Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex

Kavli Affiliate: Adam S. Charles and Patrick Kanold | Authors: Liang Xiang, Mingxuan Wang, Patrick O. Kanold and Adam Charles | Summary: Neural population activity is often stereotyped into recurring activity patterns, i.e., neural motifs, which can be seen as the fundamental building blocks in sensory processing and cognition. In this work we study the […]


Continue.. Precise Extraction of Neural Motifs Reveals Multiscale, Parallel Encoding Schemes in Auditory Cortex