Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

Kavli Affiliate: Peter Walter | Authors: Udit Dalwadi, Advait Subramanian, Aniliese Deal, Julia Conrad, Meera Venkatesh, Morgane Boone, Pascal Egea, Lingjie He, Nimit Jain, John D Lee, Yuwei Liu, Lucas Reineke, Kazuki Saito, Nathaniel Talledge, Hannah Toutkoushian, Maxence Le Vasseur, Francesca Zappa, Raoul de Groot, Diego Acosta-Alvear, Christopher Arthur, Jodi Nunnari, Mauro Costa-Mattioli, James Crawford, […]


Continue.. Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

Kavli Affiliate: Denis Wirtz | Authors: AndrĂ© Forjaz, Vasco Queiroga, Yajuan Li, Alfredo Hernandez, Ashleigh Crawford, Xiaoyu Qin, Mei Zhong, Margarita Tsapatsis, Saurabh Joshi, Donald Kramer, Oliver Nizet, Habin Bea, Yuhan Li, Shuo Qin, Robert O Flynn, Mingder Yang, Britanny Pratt, Fan Wu, Paul Gensbigler, Max Blecher, Pei-Hsun Wu, Luciane Tsukamoto Kagohara, Ie Ming Shih, […]


Continue.. 3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors

An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma

Kavli Affiliate: Charles M. Rice | Authors: Mariana N Batista, Juliano Bordignon, Ana Luiza P Mosimann, Tesia Bobrowski, Hsuan-An Chen, Gabriel Tobin-Xet, Erika A Barrall, Nataliya Prokhnevska, Abishek B Vaidya, Tyler Lewy, Kenneth H Dinnon III, Leon L Seifert, Briana Zeck, Corrine Quirk, Yu-Jui Ho, Aveline Filiol, Raphael Wolfisberg, Caroline Jiang, Bruno Cogliati, Luis Chiriboga, […]


Continue.. An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Kavli Affiliate: Robert Edwards | Authors: Rumi Habib, Ryan S. Roark, Hui Li, Andrew Jesse Connell, Michael P. Hogarty, Kshitij Wagh, Shuyi Wang, Lorie Marchitto, Ashwin N. Skelly, John W. Carey, Kirsten J. Sowers, Kasirajan Ayyanathan, Samantha J. Plante, Frederic Bibollet-Ruche, Younghoon Park, Colby J. Agostino, Ajay Singh, Christian L. Martella, Emily Lewis, Jinery Lora, […]


Continue.. Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Noradrenergic inputs to the basolateral amygdala have bidirectional effects on coping behavior and neuronal activity in mice

Kavli Affiliate: Marina Picciotto | Authors: Alexa R. Soares, Caroline Fai, Yann S. Mineur and Marina R. Picciotto | Summary: implicated in major depressive disorder and hyperactive NE signaling associated with post-traumatic stress disorder, suggesting that adequate mood regulation requires optimal NE levels. The basolateral amygdala (BLA) is a hub for stress processing and receives […]


Continue.. Noradrenergic inputs to the basolateral amygdala have bidirectional effects on coping behavior and neuronal activity in mice

Age associations with cortical and subcortical brain structure in adolescents age 9-17

Kavli Affiliate: Anders Dale | Authors: Diana M. Smith, Alison Rigby, Diliana M. Pecheva, Pravesh Parekh, Ashley Becker, Robert John Loughnan, Thomas Nichols, Terry Jernigan and Anders Dale | Summary: Introduction Adolescence is a pivotal period in brain structural development and maturation. However, investigation of cortical and subcortical brain changes during this time have been […]


Continue.. Age associations with cortical and subcortical brain structure in adolescents age 9-17

Chromosome-level genome assembly of the Brazilian merganser (Mergus octosetaceus), a rare and elusive waterfowl species

Kavli Affiliate: Erich Jarvis | Authors: Henry Paul Granger-Neto, Isaac Rafael F Borges, Davi B Cavalcanti, Davidson P Campos, Kathleen Horan, Jennifer Balacco, Brian O’Toole, Tatiana Tilley, Nivesh Jain, Linelle Abueg, Nadolina Brajuka, Giulio Paul Formenti, Olivier Fedrigo, Erich Jarvis and Fabricio R Santos | Summary: Background The Brazilian merganser (Mergus octosetaceus) is a critically […]


Continue.. Chromosome-level genome assembly of the Brazilian merganser (Mergus octosetaceus), a rare and elusive waterfowl species

Methylphenidate-induced reductions in choice impulsivity are associated with alterations in cortico-striatal beta oscillations.

Kavli Affiliate: Dhakshin Ramanathan | Authors: Jason Nan, Alyssa J Terry, Noelle Lee, Morteza Salimi, Reyana Menon, Sam A Barnes, Dhakshin S Ramanathan and Miranda Francoeur Koloski | Summary: Impulsive choice- preferring small, immediate rewards over larger, delayed reward- is a hallmark of many psychiatric disorders. Methylphenidate, a dopamine and noradrenaline transporter inhibitor, reduces impulsivity, […]


Continue.. Methylphenidate-induced reductions in choice impulsivity are associated with alterations in cortico-striatal beta oscillations.

Internal and external contexts drive distinct dynamics in shared action-encoding striatal neurons

Kavli Affiliate: Rui Costa | Authors: Tanya Sippy, Jan L. Klee, Sulekh Fernando-Peiris, Sahil Suresh, Ines Rodrigues-Vaz, Rui M. Costa and Vivek R. Athalye | Summary: Animals can flexibly initiate actions guided by external cues or by internal drive. Disease states often disrupt cue-driven and self-paced actions in distinct ways, underscoring separable neural mechanisms. Such […]


Continue.. Internal and external contexts drive distinct dynamics in shared action-encoding striatal neurons

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

Kavli Affiliate: Peter Walter | Authors: Udit Dalwadi, Advait Subramanian, Aniliese Deal, Julia Conrad, Meera Venkatesh, Morgane Boone, Pascal Egea, Lingjie He, Nimit Jain, John D Lee, Yuwei Liu, Lucas Reineke, Kazuki Saito, Nathaniel Talledge, Hannah Toutkoushian, Maxence Le Vasseur, Francesca Zappa, Raoul de Groot, Diego Acosta-Alvear, Christopher Arthur, Jodi Nunnari, Mauro Costa-Mattioli, James Crawford, […]


Continue.. Allosteric Disordering of eIF2B Regulates the Integrated Stress Response