Kavli Affiliate: Richard Axel | Authors: Andrew Jacob Pixley Fink, Samuel Muscinelli, Shuqi Wang, Marcus I Hogan, Daniel Fine English, Richard Axel, Ashok Litwin-Kumar and Carl E. Schoonover | Summary: Organisms continually tune their perceptual systems to the features they encounter in their environment1–3. We have studied how ongoing experience reorganizes the synaptic connectivity of […]
Kavli Affiliate: Robert B. Darnell and Nathaniel Heintz | Authors: Ruth A Singer, Veronika Rajchin, Kwanghoon Park, Nathaniel Heintz and Robert B Darnell | Summary: Neuronal diversity and function are intricately linked to the dynamic regulation of RNA metabolism, including splicing, localization, and translation. Electrophysiologic studies of synaptic plasticity, models for learning and memory, are […]
Kavli Affiliate: Anders Dale | Authors: Dennis van der Meer, Jakub Kopal, Alexey Shadrin, Julian Fuhrer, Jaroslav Rokicki, Sara Stinson, Srdjan Djurovic, Anders Dale and Ole Andreassen | Summary: Background Metabolic processes form the basis of the development, functioning and maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in brain […]
Kavli Affiliate: Richard Huganir | Authors: Julia Brill, Blaise Clarke, Ingie Hong and Richard L. Huganir | Summary: SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through […]
Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]
Kavli Affiliate: Li Zhao | Authors: Qing Zhao, William de Nardo, Ruoyu Wang, Yi Zhong, Umur Keles, Li Na Zhao, Huiyi Tay, Sonia Youhanna, Mengchao Yan, Ye Xie, Youngrae Kim, Sungdong Lee, Rachel Liyu Lim, Guoshou Teo, Pradeep Naraya, Paul R Burton, Volker M Lauschke, Hyungwon Choi, Matthew J Watt and Philipp Kaldis | Summary: […]
Kavli Affiliate: John Reynolds | Authors: Emily S King, Jamie L Beros, Hakuei Fujiyama, John N Reynolds and Alexander D Tang | Summary: Background: Stroke is a leading cause of disability and stroke-induced changes in cortical excitability are thought to impede functional recovery. Identifying cellular targets that contribute to maladaptive excitability holds great potential for […]
Kavli Affiliate: Shai Shaham | Authors: Rashna Sharmin, Aladin Elkhalil, Sara Pena, Pranya Gaddipati, Ginger Clark, Pavak K Shah, Mark W Pellegrino, Shai Shaham and Piya Ghose | Summary: Polarized cells (such as neurons), defined by distinct compartments are, like many cell types, subject to developmental elimination, as in neurite pruning. The molecular mechanism behind […]