Kavli Affiliate: Pietro De Camilli | Authors: Berrak Ugur, Florian Schueder, Jimann Shin, Michael G Hanna, Yumei Wu, Marianna Leonzino, Maohan Su, Anthony R. McAdow, Catherine A. Wilson, John Postlethwait, Lilianna Solnica-Krezel, Joerg Bewersdorf and Pietro De Camilli | Summary: Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between […]
Kavli Affiliate: Shawn Ferguson | Authors: Gabriel Talaia, Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Lysosomes play a pivotal role in coordinating macromolecule degradation and regulating cell growth and metabolism. Despite substantial progress in identifying lysosomal signaling proteins, understanding the pathways that synchronize lysosome functions with changing cellular demands remains incomplete. This study uncovers a […]
Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]
Kavli Affiliate: Pietro De Camilli | Authors: Nisha Mohd Rafiq, Kenshiro Fujise, Martin Rosenfeld, Peng Xu, Yumei Wu and Pietro De Camilli | Summary: Synaptojanin-1 (SJ1) is a major neuronal-enriched PI(4,5)P2 4- and 5-phosphatase implicated in the shedding of endocytic factors during endocytosis. A mutation (R258Q) that impairs selectively its 4-phosphatase activity causes Parkinsonism in […]
Kavli Affiliate: Timothy A. Ryan & Pietro De Camilli | Authors: Talex Kokotos, Aldana Antoniazzi, Santiago Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael Kaplitt, Pietro De Camilli and Timothy Ryan | Summary: Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since […]
Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]
Kavli Affiliate: Michael J Higley | Authors: Olivier Dubanet and Michael J. Higley | Summary: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely […]
Kavli Affiliate: Sreeganga Chandra | Authors: Na Wang, Biqing Zhu, Mary Alice Allnutt, Rosalie M Grijalva, Hongyu Zhao and Sreeganga S Chandra | Summary: Synapse maintenance is essential for generating functional circuitry and decrement in this process is a hallmark of neurodegenerative disease. While we are beginning to understand the basis of synapse formation, much […]
Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Yann S Mineur, Richard B Crouse, Ian M Etherington, Hanna Yousuf, Jessica J Na and Marina R Picciotto | Summary: Increased brain levels of acetylcholine (ACh) are observed in subsets of patients with depression and increasing ACh levels chronically can precipitate stress-related behaviors in humans and […]
Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]