Geometry of anisotropic contextual interactions in the visual cortex places fundamental limits on spatial vision

Posted by klaurent Yale

Kavli Affiliate: Anirvan Nandy | Authors: Mitchell P. Morton, Sachira Denagamage, Nyomi V. Hudson and Anirvan S. Nandy | Summary: Crowding, the impaired ability to accurately recognize a target stimulus among distractors, is a major bottleneck in visual perception. The spatial configuration of distractors in relation to the target profoundly influences perceptual fidelity. Notably, when […]


Continue.. Geometry of anisotropic contextual interactions in the visual cortex places fundamental limits on spatial vision

Aberrant Connectivity Across the Lifespan in a Mouse Model of Alzheimer’s disease and Rescue by mGlur5 Modulator Treatment

Posted by dbos Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Francesca Mandino, Xilin Shen, Gabriel Desrosiers-Gregoire, David O’Connor, Bandhan Mukherjee, Ashley Owens, An Qu, John Onofrey, Xenophon Papademetris, Mallar Chakravarty, Stephen M. Strittmatter and Evelyn MR Lake | Summary: Amyloid accumulation in Alzheimer’s disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of […]


Continue.. Aberrant Connectivity Across the Lifespan in a Mouse Model of Alzheimer’s disease and Rescue by mGlur5 Modulator Treatment

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

Posted by dbos Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan and Pietro De Camilli | Authors: Mukesh Kumar, Yumei Wu, Justin Knapp, Daehun Park, Kallol Gupta, Pietro De Camilli and Timothy A. Ryan | Summary: HSP54, a hereditary spastic paraplegia associated with cognitive impairment, is caused by mutations in the neuron-specific triglyceride (TG) lipase DDHD2. Loss of DDHD2 function results […]


Continue.. DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal function

VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Berrak Ugur, Florian Schueder, Jimann Shin, Michael G Hanna, Yumei Wu, Marianna Leonzino, Maohan Su, Anthony R. McAdow, Catherine A. Wilson, John Postlethwait, Lilianna Solnica-Krezel, Joerg Bewersdorf and Pietro De Camilli | Summary: Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between […]


Continue.. VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1

Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

Posted by dbos Yale

Kavli Affiliate: Shawn Ferguson | Authors: Gabriel Talaia, Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Lysosomes play a pivotal role in coordinating macromolecule degradation and regulating cell growth and metabolism. Despite substantial progress in identifying lysosomal signaling proteins, understanding the pathways that synchronize lysosome functions with changing cellular demands remains incomplete. This study uncovers a […]


Continue.. Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Posted by dbos Rockefeller, Yale

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Nisha Mohd Rafiq, Kenshiro Fujise, Martin Rosenfeld, Peng Xu, Yumei Wu and Pietro De Camilli | Summary: Synaptojanin-1 (SJ1) is a major neuronal-enriched PI(4,5)P2 4- and 5-phosphatase implicated in the shedding of endocytic factors during endocytosis. A mutation (R258Q) that impairs selectively its 4-phosphatase activity causes Parkinsonism in […]


Continue.. Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons

Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Posted by dbos Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan & Pietro De Camilli | Authors: Talex Kokotos, Aldana Antoniazzi, Santiago Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael Kaplitt, Pietro De Camilli and Timothy Ryan | Summary: Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since […]


Continue.. Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Posted by klaurent Yale

Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]


Continue.. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Olivier Dubanet and Michael J. Higley | Summary: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely […]


Continue.. Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex