Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Posted by dbos Rockefeller, Yale

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Nisha Mohd Rafiq, Kenshiro Fujise, Martin Rosenfeld, Peng Xu, Yumei Wu and Pietro De Camilli | Summary: Synaptojanin-1 (SJ1) is a major neuronal-enriched PI(4,5)P2 4- and 5-phosphatase implicated in the shedding of endocytic factors during endocytosis. A mutation (R258Q) that impairs selectively its 4-phosphatase activity causes Parkinsonism in […]


Continue.. Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons

Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Posted by dbos Rockefeller, Yale

Kavli Affiliate: Timothy A. Ryan & Pietro De Camilli | Authors: Talex Kokotos, Aldana Antoniazzi, Santiago Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael Kaplitt, Pietro De Camilli and Timothy Ryan | Summary: Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since […]


Continue.. Phosphoglycerate kinase 1 is a central leverage point in Parkinson’s disease driven neuronal metabolic deficits

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Posted by klaurent Yale

Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]


Continue.. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Olivier Dubanet and Michael J. Higley | Summary: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely […]


Continue.. Retrosplenial inputs drive diverse visual representations in the medial entorhinal cortex

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

Posted by dbos Yale

Kavli Affiliate: Sreeganga Chandra | Authors: Na Wang, Biqing Zhu, Mary Alice Allnutt, Rosalie M Grijalva, Hongyu Zhao and Sreeganga S Chandra | Summary: Synapse maintenance is essential for generating functional circuitry and decrement in this process is a hallmark of neurodegenerative disease. While we are beginning to understand the basis of synapse formation, much […]


Continue.. Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance

Acetylcholine signaling in the medial prefrontal cortex mediates the ability to learn an active avoidance response following learned helplessness training

Posted by klaurent Yale

Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Yann S Mineur, Richard B Crouse, Ian M Etherington, Hanna Yousuf, Jessica J Na and Marina R Picciotto | Summary: Increased brain levels of acetylcholine (ACh) are observed in subsets of patients with depression and increasing ACh levels chronically can precipitate stress-related behaviors in humans and […]


Continue.. Acetylcholine signaling in the medial prefrontal cortex mediates the ability to learn an active avoidance response following learned helplessness training

Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]


Continue.. Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Enhancer-driven regulatory network of forebrain human development provides insights into autism

Posted by klaurent Yale

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]


Continue.. Enhancer-driven regulatory network of forebrain human development provides insights into autism

Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids

Posted by klaurent Yale

Kavli Affiliate: Flora Vaccarino | Authors: Davide Capauto, Yifan Wang, Feinan Wu, Scott Norton, Jessica Mariani, Fumitaka Inoue, Gregory E. Crawford, The PsychENCODE Consortium, Nadav Ahituv, Alexej Abyzov and Flora M. Vaccarino | Summary: bstract Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human […]


Continue.. Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids