Kavli Affiliate: Marina Picciotto | Authors: WenLiang Zhou, Hanna Yousuf, Yann S Mineur and Marina Picciotto | Summary: Activity of the mesolimbic system is essential for adaptive performance of reward-related behaviors. Within this system, dopaminergic (DAergic) neurons play a critical role in driving motivation to obtain rewards and encoding predictions and error signals during reinforcement […]

Kavli Affiliate: Ellen J. Hoffman | Authors: April Pruitt, Liang Yang, Seoyeon Lee, Novin Balafkan, Carina Seah, Yi Dai, Elizabeth Davidson, Suha Khan, Annabel Sen, Jenny Liu, Isabel Wood, Gang Xu, Xiayuan Huang, Marina Carlson, Dejian Zhao, Priyanka Jamadagni, Grace Dossou, Kayla Retallick-Townsley, Xinyun Liu, P.J. Michael Deans, Meilin Fernandez Garcia, Huanyao Gao, Zuoheng Wang […]

Kavli Affiliate: Marina Picciotto | Authors: Rafael E Perez, Yann S Mineur, Cheryl Chen, Wenliang Zhou, Oakleigh M Folkes, Julian Lee Thompsom, Saagar S Motupally, Angelica Minier-Toribio and Marina R Picciotto | Summary: Despite well-established cellular and molecular adaptations, opioid analgesic tolerance can be rapidly reversed in settings where these drugs are not expected. The […]

Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Rolando Garcia-Milian, Ernestine Giahyue, Sofia Fertuzinhos, Florine Collin, Weiwei Wang, TuKiet Lam, Angus Nairn and Marina R Picciotto | Summary: Stressful events are a leading factor in development of depression. The medial prefrontal cortex (mPFC) is strongly associated with depression etiology and exposure to uncontrollable stressors […]

Kavli Affiliate: Anirvan Nandy | Authors: Yuxuan Xue, Mitchell P Morton, Anirvan S Nandy and Monika P Jadi | Summary: Understanding how brain state and sensory input shape inter-laminar communication is essential for interpreting cortical population dynamics. Using laminar recordings in macaque V1, we apply reduced-rank regression to quantify low-dimensional predictive subspaces linking Input and […]

Kavli Affiliate: Anirvan Nandy | Authors: Yuxuan Xue, Mitchell P Morton, Anirvan S Nandy and Monika P Jadi | Summary: Understanding how brain state and sensory input shape inter-laminar communication is essential for interpreting cortical population dynamics. Using laminar recordings in macaque V1, we apply reduced-rank regression to quantify low-dimensional predictive subspaces linking Input and […]

Kavli Affiliate: Damon Clark | Authors: Heng Wu, Tong Gou and Damon A. Clark | Summary: Illusions expose core computations in perception. In one visual apparent-motion illusion, perceptual direction is reversed when phase-shifted gratings are interleaved with uniform frames. Here, we demonstrate that Drosophila exhibits the same direction reversal reported in mammals. Combining behavior, targeted […]

Endothelial type I interferon signaling modulates the vascular response to ischemic brain injury Kavli Affiliate: Pietro De Camilli | Authors: Bodan Hu, Daniel Alvarez, Cristian Rocha-Roa, Valentin Guyard, Dazhi Li, Xinbo Wang, Pietro De Camilli, Stefano Vanni and Karin Reinisch | Summary: In eukaryotes, bridge-like lipid-transfer proteins (BLTPs) are central in mediating vesicle-independent lipid transfer […]

Kavli Affiliate: Sreeganga Chandra | Authors: Nicholas Theodosakis, Porter B. Howland, Miroslav Hejna, Stephen M. Ostrowski, Talya A. Cohen-Neamie, Remi A. Joseph, Helen Ji, Allison E. Greuel, Judth R. Boozer, Mariam Y. Demian, Alin Asim, Khanh Nguyen, Andrew M. Mu, Philip Seifert, Konrad D. Kaminiow, Yifan Zhang, Aline Fassini, Sharon Germana, Kristin C. Shaw, William […]

Kavli Affiliate: Shawn Fergusons | Authors: Tuyana Malankhanova, Zhiyong Liu, Samuel Strader, Weiping Wang, Ki Woon Sung, Zhong Li, Shawn M Ferguson and Andrew B West | Summary: LRRK2 is implicated in lysosomal functions, but the physiological upstream cues that engage endogenous LRRK2 activity are incompletely defined. Here we show that lysosomal swelling serves as […]