Kavli Affiliate: Marina Picciotto | Authors: Alexa R. Soares, Caroline Fai, Yann S. Mineur and Marina R. Picciotto | Summary: implicated in major depressive disorder and hyperactive NE signaling associated with post-traumatic stress disorder, suggesting that adequate mood regulation requires optimal NE levels. The basolateral amygdala (BLA) is a hub for stress processing and receives […]

Kavli Affiliate: Stephen Strittmatter | Authors: LaShae Nicholson, Si Jie Tang, Tejaswini Karra, Habiba Abouletta and Stephen M. Strittmatter | Summary: Metabolic dysfunction contributes to the risk and progression of Alzheimer”s disease (AD) through insulin signaling, but the cellular mechanisms are not fully understood. In this study, we examined the effects of streptozotocin-induced insulin deficiency […]

Kavli Affiliate: Marina Picciotto | Rafael E Perez, Yann S Mineur, Cheryl Chen, Wenliang Zhou, Julian Lee Thompsom, Saagar S Motupally, Angelica Minier-Toribio and Marina R Picciotto | Summary: Despite well-established cellular and molecular adaptations, opioid analgesic tolerance can be rapidly reversed in settings where these drugs are not expected. The specific neuronal populations that […]

Kavli Affiliate: Anirvan Nandy | Authors: Feng Xing, Siqi Fan, Olga Dal Monte, Monika Jadi, Steve Chang and Anirvan Nandy | Summary: Social gaze is a fundamental channel of primate communication, shaping dynamic interactions and fostering mutual understanding. While prior studies have mapped the behavioral correlates of social gaze across the prefrontal-amygdala circuits, the causal […]

Kavli Affiliate: Elena Gracheva | Authors: Tingting Gu, Elena Gracheva, Michael Lee, Wilson M Leung, Sophia Bieser, Alixandria Nielsen, Adam T. Smiley, Nhi N.T. Vuong, Matthias Walther, Gunter Reuter, Sarah C.R. Elgin and Andrew M Arsham | Summary: Eukaryotic genomes are packaged into chromatin, a regulatory nucleoprotein assembly. Establishment, maintenance, and interconversion of chromatin states […]

Kavli Affiliate: Stephen Strittmatter | Authors: Azucena Perez-Canamas, Mingming Chen, Leire Almandoz-Gil, Nabab Khan, Si Jie Tang, Allyson Ho, Erik C Gunther and Stephen M. Strittmatter | Summary: Fibrils of misfolded α-synuclein (α-syn) accumulate in Parkinson’s disease and other synucleinopathies, spreading between cells to template further misfolding and drive neurodegeneration. α-syn fibril entry into healthy […]

Kavli Affiliate: Vikaas Sohal | Authors: Cesar P Canales, Stephanie A Lozano, Nicholas A Frost, Karol Cichewicz, Wellington Amaral, Nicolas Seban, Ethan Fenton, Ayanna Wade, Nickolas Chu, Emily Smith, Cory Ardekani, Samuel Frank, Jeffrey Bennett, Pierre Lavenex, Aspen Kopley-Smith, Darlene Rahbarian, Melisa Corea, Daniela Perla, Liam Davis, Jiyuan Zhu, Rebecca Ortiz, Paris Beauregard, Sarah Morse, […]

Kavli Affiliate: Shawn Ferguson | Authors: Layla M Nassar, xiaojian Shi, Agnes Roczniak-Ferguson, Hongying Shen and Shawn M Ferguson | Summary: Lysosomes break down macromolecules, clear cellular waste and recycle nutrients such as cystine. We describe a novel mechanism whereby JIP4 regulates lysosomal cystine storage by controlling the abundance of cystinosin (CTNS), the transporter responsible […]

Kavli Affiliate: Pietro De Camilli | Authors: Peng Xu, Rubia Isler Mancuso, Marianna Leonzino, Caroline J Zeiss, Diane S Krause and Pietro De Camilli | Summary: VPS13 is the founding member of a family of proteins that mediate lipid transfer at intracellular membrane contact sites by a bridge-like mechanism. Mammalian genomes comprise 4 VPS13 genes […]

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]