Kavli Affiliate: Timothy A. Ryan & Pietro De Camilli | Authors: Talex Kokotos, Aldana Antoniazzi, Santiago Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael Kaplitt, Pietro De Camilli and Timothy Ryan | Summary: Phosphoglycerate kinase 1 (PGK1), the first ATP producing glycolytic enzyme, has emerged as a therapeutic target for Parkinson’s Disease (PD), since […]
Kavli Affiliate: Anirvan Nandy, John Reynolds | Authors: Mitchell P Morton, Sachira Denagamage, Isabel J Blume, John H Reynolds, Monika P Jadi and Anirvan S Nandy | Summary: Identical stimuli can be perceived or go unnoticed across successive presentations, producing divergent behavioral outcomes despite similarities in sensory input. We sought to understand how fluctuations in […]
Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]
Kavli Affiliate: Michael J Higley | Authors: Olivier Dubanet and Michael J. Higley | Summary: The ability of rodents to use visual cues for successful navigation and goal-directed behavior has been long appreciated, although the neural mechanisms supporting sensory representations in navigational circuits are largely unknown. Navigation is fundamentally dependent on the hippocampus and closely […]
Kavli Affiliate: Sreeganga Chandra | Authors: Na Wang, Biqing Zhu, Mary Alice Allnutt, Rosalie M Grijalva, Hongyu Zhao and Sreeganga S Chandra | Summary: Synapse maintenance is essential for generating functional circuitry and decrement in this process is a hallmark of neurodegenerative disease. While we are beginning to understand the basis of synapse formation, much […]
Kavli Affiliate: Marina Picciotto | Authors: Zuhair I Abdulla, Yann S Mineur, Richard B Crouse, Ian M Etherington, Hanna Yousuf, Jessica J Na and Marina R Picciotto | Summary: Increased brain levels of acetylcholine (ACh) are observed in subsets of patients with depression and increasing ACh levels chronically can precipitate stress-related behaviors in humans and […]
Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]
Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]
Kavli Affiliate: Flora Vaccarino | Authors: Davide Capauto, Yifan Wang, Feinan Wu, Scott Norton, Jessica Mariani, Fumitaka Inoue, Gregory E. Crawford, The PsychENCODE Consortium, Nadav Ahituv, Alexej Abyzov and Flora M. Vaccarino | Summary: bstract Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human […]
Kavli Affiliate: Pietro De Camilli | Authors: Chase Amos, Peng Xu and Pietro De Camilli | Summary: Mutations of the bridge-like lipid transport protein VPS13A and of the lipid scramblase XK result in Chorea Acanthocytosis (ChAc) and McLeod syndrome (MLS) respectively, two similar conditions involving neurodegeneration and deformed erythrocytes (acanthocytes). VPS13A binds XK, suggesting a […]