Kavli Affiliate: Vikaas Sohal | Authors: Aarron Justin Phensy, Lara Louise Hagopian and Vikaas Singh Sohal | Summary: The prefrontal cortex (PFC) is required for many cognitive processes that are disrupted in conditions such as schizophrenia. The PFC is composed of neuronal networks which are organized by both local microcircuitry and inter-regional projections, within which […]
Kavli Affiliate: Robert Edwards | Authors: George Bouras, Louise M Judd, Robert A Edwards, Sarah Vreugde, Timothy P. Stinear and Ryan R Wick | Summary: It is now possible to assemble near-perfect bacterial genomes using Oxford Nanopore Technologies (ONT) long reads, but short-read polishing is still required for perfection. However, the effect of short-read depth […]
Kavli Affiliate: Edward Chang | Authors: Andrew Moses Lee, Virginia Sturm, Heather Dawes, Andrew D Krystal and Edward Chang | Summary: Anxiety is a common symptom across psychiatric disorders, but the neurophysiological underpinnings of these symptoms remain unclear. This knowledge gap has prevented the development of circuit-based treatments that can target the neural substrates underlying […]
Kavli Affiliate: Michael Keiser | Authors: Leo Gendelev, Jack Taylor, Douglas Myers-Turnbull, Steven Chen, Matthew N. McCarroll, Michelle R. Arkin, David Kokel and Michael J. Keiser | Summary: Behavioral larval zebrafish screens leverage a high-throughput small molecule discovery format to find neuroactive molecules relevant to mammalian physiology. We screened a library of 650 central nervous […]
Kavli Affiliate: Alexandra Nelson | Authors: Xiaowen Zhuang, Julia Lemak, Sadhana Sridhar and Alexandra B Nelson | Summary: Healthy action selection relies on the coordinated activity of striatal direct and indirect pathway neurons. In Parkinson’s disease (PD), in which loss of midbrain dopamine neurons is associated with progressive motor and cognitive deficits, this coordination is […]
Kavli Affiliate: Hana El-Samad | Authors: Matthew S Kim, Hersh K Bhargava, Gavin E Shavey, Wendell A Lim, Hana El-Samad and Andrew H Ng | Summary: Chimeric antigen receptor (CAR) T cells have made a tremendous impact in the clinic, but potent signaling through the CAR can be detrimental to treatment safety and efficacy. The […]
Kavli Affiliate: Robert Edwards | Authors: Qianyi E Zhang, Jared Lindenberger, Ruth Parsons, Bhishem Thakur, Rob Parks, Chan Soo Park, Xiao Huang, Salam Sammour, Katarzyna Janowska, Taylor N Spence, Robert J. Edwards, Mitchell Martin, Wilton B Williams, Sophie Gobeil, David C Montefiori, Bette Korber, Kevin O’Neil Saunders, Barton F Haynes, Barton F. Haynes, Rory Henderson […]
Kavli Affiliate: Anatol Kreitzer | Authors: Robyn St. Laurent, Kelly M Kusche, Anatol C Kreitzer and Robert C Malenka | Summary: Background The avoidance of aversive stimuli due to negative reinforcement learning is critical for survival in real-world environments, which demand dynamic responding to both positive and negative stimuli that often conflict with each other. […]
Kavli Affiliate: Loren Frank | Authors: Anna K Gillespie, Daniela A Astudillo Maya, Eric L. Denovellis, Sachi Desse and Loren M Frank | Summary: Hippocampal replay – the time-compressed, sequential reactivation of ensembles of neurons related to past experience – is a key neural mechanism of memory consolidation. Replay typically coincides with a characteristic pattern […]
Kavli Affiliate: Jeremy Willsey | Authors: Belinda Wang, Rasika Vartak, Yefim Zaltsman, Zun Zar Chi Naing, Kelsey M Hennick, Benjamin J Polacco, Ali Bashir, Manon Eckhardt, Mehdi Bouhaddou, Jiewei Xu, Nawei Sun, Micaela Lasser, Yuan Zhou, Keelan Z Guiley, Una Chan, Julia A Kaye, Prachi Khare, Sam Drake, Vanessa Drury, David F Burke, Silvano Gonzalez, […]