Kavli Affiliate: Alex Pollen | Authors: Nathan K Schaefer, Bryan J Pavlovic and Alex Aaron Pollen | Summary: Pooled processing, in which cells from multiple sources are cultured or captured together, is an increasingly popular strategy for droplet-based single cell sequencing studies. This design allows efficient scaling of experiments, isolation of cell-intrinsic differences, and mitigation […]

Kavli Affiliate: Robert Edwards | Authors: Laura K Inglis, Michael J Roach, Susanna R Grigson and Robert A. Edwards | Summary: Prophages—viruses that integrate into bacterial genomes—are ubiquitous in the microbial realm. Prophages contribute significantly to horizontal gene transfer, including the potential spread of antimicrobial resistance (AMR) genes, because they can collect host genes. Understanding […]

Kavli Affiliate: Kevin Bender | Authors: Mitchell J. Vaughn, Kevin J. Bender and Julie S. Haas | Summary: Electrical synapses are present widely across the mammalian brain and are crucial components of active neural circuitry and connectomes. Identification of electrically coupled networks in living tissue has been limited by technical demands of multiplexed recordings, and […]

Kavli Affiliate: Alexandra Nelson and Anatol Kreitzer | Authors: Katerina L Rademacher, Zak Doric, Dominik Haddad, Aphroditi Mamaligas, Szu-Chi Liao, Rose Creed, Kohei Kano, Zac Chatterton, Yuhong Fu, Joseph H Garcia, Victoria Vance, Yoshitaka Sei, Anatol Kreitzer, Glenda Halliday, Alexandra Nelson, Elyssa Margolis and Ken L Nakamura | Summary: Parkinson’s disease (PD) is characterized by […]

Kavli Affiliate: Peter Walter | Authors: Kristof Torkenczy, Lucas C Reineke, Sean W Dooling, Benjamin W Henderson, Daniel Itzhak, Benjamin Yang, Dongze He, Richard M Myers, Peter Walter, Stefka Tyanova and Mauro Costa-Mattioli | Summary: Persistent activation of the integrated stress response (ISR) is a major driver of cognitive decline in both neurodevelopmental and neurodegenerative […]

Kavli Affiliate: Yifan Cheng | Authors: Junrui Li, Yifei chen, Shawn Zheng, Angus McDonald, John W. Sedat, David A. Agard and Yifan Cheng | Summary: With technological advancements in recent years, single particle cryogenic electron microscopy (cryo-EM) has become a major methodology for structural biology. Structure determination by single particle cryo-EM is premised on randomly […]

Kavli Affiliate: Anna Molofsky and Christoph Kirst | Authors: Haruna Nakajo, Ran Cao, Supriya A. Mula, Justin McKetney, Nicholas J. Silva, Muskaan Shah, Indigo V.L. Rose, Martin Kampmann, Danielle L. Swaney, Christoph Kirst and Anna V. Molofsky | Summary: Maintaining a dynamic neuronal synapse pool is critical to brain development. The extracellular matrix (ECM) regulates […]

Kavli Affiliate: Reza Abbasi Asl | Authors: Alex Jihun Lee, Shenqin Yao, Nicholas Lusk, Hongkui Zeng, Bosiljka Tasic and Reza Abbasi-Asl | Summary: Spatial transcriptomics offers unique opportunities to define the spatial organization of tissues and organs, such as the mouse brain. We address a key bottleneck in the analysis of organ-scale spatial transcriptomic data […]

Kavli Affiliate: Robert Edwards | Authors: Aaron J. May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Moumita Dutta, Maggie Barr, Rob Parks, Amanda Newman, Xiao Huang, Kijun Song, Victor Ilevbare, Salam Sammour, Chan Soo Park, Radha Devkota Adhikari, Priyanka Devkota, Katarzyna Janowska, Yanshun Liu, Garrett Scapellato, Taylor N. Spence, Katayoun Mansouri, Robert J Edwards, […]

Kavli Affiliate: Edward Chang | Authors: Duo Xu, Jason E Chung, Alexander B Silva, Quinn R Greicius, Sean L Metzger, Yizhen Zhang, Matthew K Leonard, Manish K Aghi, Shawn L Hervey-Jumper and Edward F Chang | Summary: Speech perception and production are interconnected processes, but the underlying neural mechanisms remain unclear. We investigated this relationship […]