A cross-species proteomic map of synapse development reveals neoteny during human postsynaptic density maturation

Kavli Affiliate: Arturo Alvarez-Buylla, Nenad Sestan, Alex Pollen, Arnold Kriegstein | Authors: Li Wang, Kaifang Pang, Li Zhou, Arantxa Cebrian-Silla, Susana Gonzalez-Granero, Shaohui Wang, Qiuli Bi, Matthew L. White, Brandon Ho, Jiani Li, Tao Li, Yonatan Perez, Eric J. Huang, Ethan A Winkler, Mercedes F Paredes, Rothem Kovner, Nenad Sestan, Alex A. Pollen, Pengyuan Liu, […]


Continue.. A cross-species proteomic map of synapse development reveals neoteny during human postsynaptic density maturation

Towards the biogeography of butyrate-producing bacteria

Kavli Affiliate: Robert Edwards | Authors: Joel E Brame, Craig Liddicoat, Catherine A Abbott, Robert A Edwards, Jake M Robinson, Nicolas E Gauthier and Martin F Breed | Summary: Butyrate-producing bacteria are found in many ecosystems and organisms, including humans, and are vital to ecosystem functionality and human health. These bacteria ferment organic matter, producing […]


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Allosteric regulation of TRPV1 by the inflammatory lipid, LPA

Kavli Affiliate: Yifan Cheng | Authors: William Randall Arnold, David Julius and Yifan Cheng | Summary: Transient Receptor Potential Vanilloid 1 (TRPV1) is a tetrameric cation channel expressed in primary afferent neurons, where it contributes to thermosensation and nociception. TRPV1 is a polymodal signal integrator that responds not only to heat, but also to inflammatory […]


Continue.. Allosteric regulation of TRPV1 by the inflammatory lipid, LPA

Anatomical registration of intracranial electrodes. Robust model-based localization and deformable smooth brain-shift compensation methods

Kavli Affiliate: Edward Chang | Authors: Alejandro Omar Blenkmann, Sabine Liliana Leske, Anais Llorens, Jack J Lin, Edward Chang, Peter Brunner, Gerwin Schalk, Jugoslav Ivanovic, Pal Gunnar Larsson, Robert Thomas Knight, Tor Endestad and Anne-Kristin Solbakk | Summary: Precise electrode localization is important for maximizing the utility of intracranial EEG data. Electrodes are typically localized […]


Continue.. Anatomical registration of intracranial electrodes. Robust model-based localization and deformable smooth brain-shift compensation methods

Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Model Based Predictions and Validation in Three Human Subjects

Kavli Affiliate: Philip Starr | Authors: James J. Sermon, Maria Olaru, Juan Anso, Stephanie Cernera, Simon Little, Maria Shcherbakova, Rafal Bogacz, Philip A. Starr, Timothy Denison and Benoit Duchet | Summary: Objectives The exact mechanisms of deep brain stimulation (DBS) are still an active area of investigation, in spite of its clinical successes. This is […]


Continue.. Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Model Based Predictions and Validation in Three Human Subjects

Prophage rates in the human microbiome vary by body site and host health.

Kavli Affiliate: Robert Edwards | Authors: Laura K Inglis, Michael J. Roach and Robert A Edwards | Summary: Phages integrated into a bacterial genome–called prophages–continuously monitor the health of the host bacteria to determine when to escape the genome, protect their host from other phage infections, and may provide genes that promote bacterial growth. Prophages […]


Continue.. Prophage rates in the human microbiome vary by body site and host health.

Adrenomedullin promotes interneuron migration in a dual human model for hypoxic interneuronopathy of prematurity.

Kavli Affiliate: Jeremy Willsey | Authors: Wojciech M Michno, Alyssa Puno, Li Li, Amanda Everitt, Kate McCluskey, Fikri Birey, Saw Htun, Dhriti Nagar, Yuqin Dai, Emily Gurwitz, Jeremy Willsey and Anca M Pasca | Summary: Extremely preterm born individuals at < 28 postconceptional weeks (PCW) are at high risk for encephalopathy of prematurity and life-long […]


Continue.. Adrenomedullin promotes interneuron migration in a dual human model for hypoxic interneuronopathy of prematurity.

A spatially resolved single cell genomic atlas of the adult human breast

Kavli Affiliate: Robert Edwards | Authors: Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Hu, Anna Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Ken Chen, Benedikt Nilges, Nachiket Kashikar, Oliver Braubach, Bassem Cheikh, Nadya Nikulina, Hui Chen, Mediate Teshome, Brian Menegaz, Huma […]


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The Promise and Pitfalls of Prophages

Kavli Affiliate: Robert Edwards | Authors: Jody C McKerral, Bhavya Nalagampalli Papudeshi, Laura K Inglis, Michael J Roach, Przemyslaw Decewicz, Katelyn McNair, Antoni Luque, Elizabeth A Dinsdale and Robert A Edwards | Summary: Phages dominate every ecosystem on the planet. While virulent phages sculpt the microbiome by killing their bacterial hosts, temperate phages provide unique […]


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Axon initial segment GABA inhibits action potential generation throughout periadolescent development

Kavli Affiliate: Kevin Bender | Authors: Anna M Lipkin and Kevin J Bender | Summary: Neurons are remarkably polarized structures: dendrites spread and branch to receive synaptic inputs while a single axon extends and transmits action potentials to downstream targets. Neuronal polarity is maintained by the axon initial segment (AIS), a region between the soma […]


Continue.. Axon initial segment GABA inhibits action potential generation throughout periadolescent development