Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Kavli Affiliate: John Rubenstein | Authors: Siavash Fazel Darbandi, Joon Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, Athena Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S Nord, Stephan J. Sanders and John L.R. Rubenstein | Summary: SUMMARY Many autism spectrum disorder (ASD)-associated genes act as transcriptional regulators (TRs). ChIP-seq was used to identify […]


Continue.. Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes.

Contrasting synaptic roles of MDGA1 and MDGA2

Kavli Affiliate: Roger Nicoll | Authors: Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N Chau, Julie C. Lauterborn, Salvatore Incontro, Kathy H. Li, Alma L. Burlingame, Katherine W. Roche, Christine M. Gall, Roger A. Nicoll and Javier Diaz-Alonso | Summary: Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing […]


Continue.. Contrasting synaptic roles of MDGA1 and MDGA2

Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

Kavli Affiliate: Robert Edwards | Authors: Swayam Fnu Prakash, Nisha R Dhanushkodi, Latifa Zayou, Izabela Coimbra Ibraim, Afshana Quadiri, Pierre Gregoire Coulon, Delia F Tifrea, Berfin Suzler, Mohamed Amin, Amruth Chilukuri, Robert A Edwards, Hawa Vahed, Anthony B. Nesburn, Baruch D Kuppermann, Jeffrey B Ulmer, Dan Gil, Trevor M Jones and Lbachir BenMohamed | Summary: […]


Continue.. Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

Kavli Affiliate: Robert Edwards | Authors: David Martinez, Alexandra R. Schaefer, Tyler Gavitt, Michael Mallory, Esther Lee, Nicholas Catanzaro, Haiyan Chen, Kendra Gully, Trevor D. Scobey, Pooja Korategere, Alecia Brown, Lena Smith, Robert Parks, Maggie Barr, Amanda Newman, Cindy Bowman, John M. Powers, Katayoun Mansouri, Robert J Edwards, Ralph S. Baric, Barton Haynes and Kevin […]


Continue.. Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

Molecular recording of calcium signaling via calcium-dependent protein proximity labeling

Kavli Affiliate: Yuh Nung Jan | Authors: Jungwoo Wren Kim, Adeline J. H. Yong, Erin E. Aisenberg, Ted M. Dawson, Valina L. Dawson, Yuh-Nung Jan, Nicholas T. Ingolia, Wei Wang, Ruixuan Gao and Helen S. Bateup | Summary: Calcium ions serve as key intracellular signals. Local, transient increases in calcium concentrations can activate calcium sensor […]


Continue.. Molecular recording of calcium signaling via calcium-dependent protein proximity labeling

A cross-species proteomic map of synapse development reveals neoteny during human postsynaptic density maturation

Kavli Affiliate: Arturo Alvarez-Buylla, Nenad Sestan, Alex Pollen, Arnold Kriegstein | Authors: Li Wang, Kaifang Pang, Li Zhou, Arantxa Cebrian-Silla, Susana Gonzalez-Granero, Shaohui Wang, Qiuli Bi, Matthew L. White, Brandon Ho, Jiani Li, Tao Li, Yonatan Perez, Eric J. Huang, Ethan A Winkler, Mercedes F Paredes, Rothem Kovner, Nenad Sestan, Alex A. Pollen, Pengyuan Liu, […]


Continue.. A cross-species proteomic map of synapse development reveals neoteny during human postsynaptic density maturation

Towards the biogeography of butyrate-producing bacteria

Kavli Affiliate: Robert Edwards | Authors: Joel E Brame, Craig Liddicoat, Catherine A Abbott, Robert A Edwards, Jake M Robinson, Nicolas E Gauthier and Martin F Breed | Summary: Butyrate-producing bacteria are found in many ecosystems and organisms, including humans, and are vital to ecosystem functionality and human health. These bacteria ferment organic matter, producing […]


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Allosteric regulation of TRPV1 by the inflammatory lipid, LPA

Kavli Affiliate: Yifan Cheng | Authors: William Randall Arnold, David Julius and Yifan Cheng | Summary: Transient Receptor Potential Vanilloid 1 (TRPV1) is a tetrameric cation channel expressed in primary afferent neurons, where it contributes to thermosensation and nociception. TRPV1 is a polymodal signal integrator that responds not only to heat, but also to inflammatory […]


Continue.. Allosteric regulation of TRPV1 by the inflammatory lipid, LPA

Anatomical registration of intracranial electrodes. Robust model-based localization and deformable smooth brain-shift compensation methods

Kavli Affiliate: Edward Chang | Authors: Alejandro Omar Blenkmann, Sabine Liliana Leske, Anais Llorens, Jack J Lin, Edward Chang, Peter Brunner, Gerwin Schalk, Jugoslav Ivanovic, Pal Gunnar Larsson, Robert Thomas Knight, Tor Endestad and Anne-Kristin Solbakk | Summary: Precise electrode localization is important for maximizing the utility of intracranial EEG data. Electrodes are typically localized […]


Continue.. Anatomical registration of intracranial electrodes. Robust model-based localization and deformable smooth brain-shift compensation methods

Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Model Based Predictions and Validation in Three Human Subjects

Kavli Affiliate: Philip Starr | Authors: James J. Sermon, Maria Olaru, Juan Anso, Stephanie Cernera, Simon Little, Maria Shcherbakova, Rafal Bogacz, Philip A. Starr, Timothy Denison and Benoit Duchet | Summary: Objectives The exact mechanisms of deep brain stimulation (DBS) are still an active area of investigation, in spite of its clinical successes. This is […]


Continue.. Sub-harmonic Entrainment of Cortical Gamma Oscillations to Deep Brain Stimulation in Parkinson’s Disease: Model Based Predictions and Validation in Three Human Subjects