Kavli Affiliate: Robert Edwards | Authors: Frederic Bibollet-Ruche, Ronnie M Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N Skelly, Ryan S Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, Andrew Connell, Hui Li, Elena E Giorgi, Ge S Song, Shilei Ding, […]

Kavli Affiliate: John Rubenstein | Authors: Siavash Fazel Darbandi, Joon-Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, Athena R. Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S. Nord, Stephan J. Sanders and John L. R. Rubenstein | Summary: Abstract The authors have withdrawn their manuscript because of uncertainty about an antibody reagent that was […]

Kavli Affiliate: Robert Edwards | Authors: Joel E Brame, Craig Liddicoat, Catherine A Abbott, Robert A Edwards, Jake M Robinson, Nicolas E Gauthier and Martin F Breed | Summary: Abstract Butyrate-producing bacteria are found in many ecosystems and organisms, including humans. They ferment organic matter, producing the by-product butyrate, a short-chain fatty acid with important […]

Kavli Affiliate: Daniel Minor | Authors: Zhou Chen, Abhisek Mondal, Fayal Abderemane-Ali, Jose Montano, Balyn Zaro and Daniel L Minor, Jr. | Summary: Abstract Voltage-gated ion channels (VGICs) comprise multiple structural units whose assembly is required for function1,2. There is scant structural understanding of how VGIC subunits assemble and whether chaperone proteins are required. High-voltage […]

Kavli Affiliate: Alex Pollen | Authors: Kathleen C Keough, Sean Whalen, Fumitaka Inoue, Pawel F Przytycki, Tyler Fair, Chengyu Deng, Marilyn Steyert, Hane Ryu, Kerstin Lindblad-Toh, Elinor Karlsson, Zoonomia Consortium, Tomasz J. Nowakowski, Nadav J. Ahituv, Alex Aaron Pollen and Katherine S Pollard | Summary: Abstract Human Accelerated Regions (HARs) are conserved genomic loci that […]

Kavli Affiliate: Stanley Prusiner | Authors: Gregory E. Merz, Matthew J. Chalkley, Sophia Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado and Daniel R. Southworth | Summary: Abstract Neurodegenerative diseases (NDs) are characterized by the formation of amyloid filaments that adopt disease-specific conformations in the brain. Recently developed small […]

Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: Abstract NMDA receptor autoimmune encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause behavioral and neurologic deficits. Although many symptoms are responsive to immunotherapy, […]

Kavli Affiliate: Edward Chang | Authors: Jacqueline A Overton, Karen A Moxon, Matthew P Stickle, Logan M Peters, Jack J Lin, Edward F Chang, Robert T Knight, Ming Hsu and Ignacio Saez | Summary: Abstract Value-based decision-making involves multiple cortical and subcortical brain areas, but the exact nature of neural activity underlying choice behavior has […]

Kavli Affiliate: Kevin Bender | Authors: Selin Schamiloglu, Elinor Lewis, Anne C Hergarden, Kevin Bender and Jennifer L Whistler | Summary: ABSTRACT Second generation antipsychotics (SGAs) are front-line treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictability in treatment efficacy remain unclear. All […]

Kavli Affiliate: Michael Keiser | Authors: Laura M Gunsalus, Michael J. Keiser and Katherine S Pollard | Summary: Abstract Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome-wide. We developed an in silico deep-learning strategy to quantify the […]