A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.

Kavli Affiliate: Peter Walter | Authors: Advait Subramanian, Lan Wang, Tom Moss, Mark Voorhies, Smriti Sangwan, Erica Stevenson, Ernst H Pulido, Samentha Kwok, Nevan J Krogan, Danielle L Swaney, Stephen N Floor, Anita Sil, Peter Walter and Shaeri Mukherjee | Summary: Pathogens often secrete proteins or nucleic acids that mimic the structure and/or function of […]


Continue.. A Legionella toxin mimics tRNA and glycosylates the translation machinery to trigger a ribotoxic stress response.

Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family

Kavli Affiliate: Daniel Minor | Authors: Zhou Chen, Sandra Zakrzewska, Holly S. Hajare, Aurora Alvarez-Buylla, Fayal Abderemane-Ali, Maximiliana Bogan, Dave Ramirez, Lauren A. O’Connell, J. Du Bois and Daniel L. Minor, Jr. | Summary: American bullfrog (Rana castesbeiana) saxiphilin (RcSxph) is a high-affinity ‘toxin sponge’ protein thought to prevent intoxication by saxitoxin (STX), a lethal […]


Continue.. Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family

Spatiotemporal recruitment of inhibition and excitation in the mammalian cortex during electrical stimulation

Kavli Affiliate: Michael Stryker | Authors: Maria C. Dadarlat, Yujiao Jennifer Sun and Michael P Stryker | Summary: Electrical stimulation has emerged as a powerful and precise treatment in which to modulate aberrant neural activity patterns common in neural dysfunction and disease; however, the physiological process involved in microstimulation is poorly understood, particularly regarding the […]


Continue.. Spatiotemporal recruitment of inhibition and excitation in the mammalian cortex during electrical stimulation

Recording gene expression order in DNA by CRISPR addition of retron barcodes

Kavli Affiliate: Seth Shipman | Authors: Santi Bhattarai-Kline, Sierra K. Lear, Chloe B. Fishman, Santiago C. Lopez, Elana R. Lockshin, Max G. Schubert, Jeff Nivala, George Church and Seth L. Shipman | Summary: Biological processes depend on the differential expression of genes over time, but methods to make physical recordings of these processes are limited. […]


Continue.. Recording gene expression order in DNA by CRISPR addition of retron barcodes

Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition

Kavli Affiliate: Susanna Rosi, Peter Walter, Michael Stryker | Authors: Elma S. Frias, Mahmood S. Hoseini, Karen Krukowski, Maria Serena Paladini, Katherine Grue, Gonzalo Ureta, Kira D.A. Rienecker, Peter Walter, Michael P. Stryker and Susanna Rosi | Summary: Traumatic brain injury (TBI) is a leading cause of long-term neurological disability in the world and the […]


Continue.. Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition

Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites

Kavli Affiliate: Kevin Bender | Authors: Andrew D. Nelson, Amanda M. Catalfio, Julie M. Gupta, Lia Min, René N. Caballero-Florán, Kendall P. Dean, Carina C. Elvira, Kimberly D. Derderian, Henry Kyoung, Atehsa Sahagun, Stephan J Sanders, Kevin Bender and Paul M Jenkins | Summary: Dysfunction in sodium channels and their ankyrin scaffolding partners have both […]


Continue.. Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

Kavli Affiliate: Arnold Kriegstein, Alex Pollen | Authors: Sean Whalen, Fumitaka Inoue, Hane Ryu, Tyler Fair, Eirene Markenscoff-Papadimitriou, Kathleen Keough, Martin Kircher, Beth Martin, Beatriz Alvarado, Orry Elor, Dianne Laboy Cintron, Alex Williams, Md. Abul Hassan Samee, Sean Thomas, Robert Krencik, Erik Ullian, Arnold Kriegstein, Jay Shendure, Alex Pollen, Nadav Ahituv and Katherine Pollard | […]


Continue.. Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

Prioritizing virtual screening with interpretable interaction fingerprints

Kavli Affiliate: Michael Keiser | Authors: Alexandre V Fassio, Laura Shub, Luca Ponzoni, Jessica McKinley, Matthew J O’Meara, Rafaela S Ferreira, Michael J Keiser and Raquel C de Melo Minardi | Summary: Machine learning-based drug discovery success depends on molecular representation. Yet traditional molecular fingerprints omit both the protein and pointers back to structural information […]


Continue.. Prioritizing virtual screening with interpretable interaction fingerprints

The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Kavli Affiliate: John Rubenstein | Authors: Shiona Biswas, C. Savio Chan, John L.R. Rubenstein and Lin Gan | Summary: The external globus pallidus (Gpe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both […]


Continue.. The transcription regulator Lmo3 is required for cell fate specification in the external globus pallidus

Hecatomb: An End-to-End Research Platform for Viral Metagenomics

Kavli Affiliate: Robert Edwards | Authors: Michael J. Roach, Sarah Beecroft, Kathie Mihindukulasuriya, Leran Wang, Lais Farias Oliveira Lima, Elizabeth A. Dinsdale, Robert Edwards and Scott Allyn Handley | Summary: Analysis of viral diversity using modern nucleic acid sequencing technologies presents several unique challenges. Foremost being that virus detection requires a non-targeted, random (shotgun) approach. […]


Continue.. Hecatomb: An End-to-End Research Platform for Viral Metagenomics