Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

Kavli Affiliate: Robert Edwards | Authors: Fei Li, Jacob Eriksen, Juan A Oses-Prieto, Yessica K Gomez, Hongfei Xu, Janet Finer-Moore, Phuong Nguyen, Alisa Bowen, Andrew Nelson, Alma Burlingame, Michael Grabe, Robert Stroud and Robert Edwards | Summary: Abstract Concentration of neurotransmitter inside synaptic vesicles (SVs) underlies the quantal nature of synaptic transmission. In contrast to […]


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Neuronal Activity Alters Neuron to OPC Synapses

Kavli Affiliate: Samuel Pleasure | Authors: Daniela S Moura, Alekhya Parvathaneni, Atehsa Sahagun, Hirofumi Noguchi, Iris Tilton, Emma Brennan, Robert M Brock, Lindsay R. Halladay, Samuel J Pleasure and Laura A. Cocas | Summary: Abstract The mechanisms that drive the timing and specificity of oligodendrocyte myelination during development, or remyelination after injury or immune attack […]


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Cortical surface electrical potentials are composed of multiple bandlimited frequency components, including high-gamma

Kavli Affiliate: Kristofer Bouchard, Edward Chang | Authors: Jesse A Livezey, Ahyeon Hwang, Kseniya Usovich, Maximilian Dougherty, Edward F Chang and Kristofer E Bouchard | Summary: A common challenge in neuroscience is how to decompose noisy, multi-source signals measured in experiments into biophysically interpretable components. Analysis of cortical surface electrical potentials (CSEPs) measured using electrocorticography […]


Continue.. Cortical surface electrical potentials are composed of multiple bandlimited frequency components, including high-gamma

Oxytocin receptor is not required for social attachment in prairie voles

Kavli Affiliate: Devanand Manoli | Authors: Kristen M. Berendzen, Ruchira Sharma, Maricruz Alvarado, YiChao Wei, Forrest D. Rogers, Adele Seelke, Trenton C. Simmons, Jessica Bond, Rose D. Larios, Michael Sherman, Srinivas Parthasarathy, Isidero Espineda, Joseph R. Knoedler, Annaliese Beery, Karen L. Bales, Nirao M Shah and Devanand S. Manoli | Summary: Prairie voles are among […]


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Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors

Kavli Affiliate: Kira Poskanzer | Authors: Silvia Pittolo, Sae Yokoyama, Drew Willoughby, Charlotte Taylor, Michael Reitman, Vincent Tse, Zhaofa Wu, Roberto Etchenique, Yulong Li and Kira E Poskanzer | Summary: The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters and […]


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Compression-enabled interpretability of voxel-wise encoding models

Kavli Affiliate: Reza Abbasi-Asl | Authors: Fatemeh Kamali, Amir Abolfazl Suratgar, Mohammadbagher Menhaj and Reza Abbasi-Asl | Summary: Voxel-wise encoding models based on convolutional neural networks (CNNs) have emerged as state-of-the-art predictive models of brain activity evoked by natural movies. Despite the superior predictive performance of CNN-based models, the huge number of parameters in these […]


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High-Speed Imaging Reveals the Bimodal Nature of Dense Core Vesicle Exocytosis

Kavli Affiliate: Robert Edwards | Authors: Pengcheng Zhang, David Rumschitzki and Robert H Edwards | Summary: During exocytosis, the fusion of secretory vesicle with plasma membrane forms a pore that regulates release of neurotransmitter and peptide. Heterogeneity of fusion pore behavior has been attributed to stochastic variation in a common exocytic mechanism, implying a lack […]


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Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

Kavli Affiliate: Robert Edwards | Authors: Sai Luo, Jun Zhang, Alex J.B. Kreutzberger, Amanda Eaton, Robert J. Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D. Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S. […]


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Dynamic top-down biasing implements rapid adaptive changes to individual movements

Kavli Affiliate: Michael Brainard | Authors: Lucas Y Tian, Timothy L Warren and Michael S Brainard | Summary: Complex behaviors depend on the coordinated activity of neural ensembles in interconnected brain areas. The behavioral function of such coordination, often measured as co-fluctuations in neural activity across areas, is poorly understood. One hypothesis is that rapidly […]


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Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

Kavli Affiliate:Allan Basbaum | Authors: Isha Singh, Anubha Seth, Christian B. Billesbolle, Joao Braz, Ramona M. Rodriguiz, Kasturi Roy, Bethlehem Bekele, Veronica Craik, Xi-Ping Huang, Danila Boytsov, Parnian Lak, Henry R O’Donnell, Walter R Sandtner, Bryan L. Roth, Allan Basbaum, William C Wetsel, Aashish Manglik, Brian K. Shoichet and Gary Rudnick | Summary: The serotonin […]


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