Encoding of melody in the human auditory cortex

Kavli Affiliate: Edward Chang | Authors: Narayan Sankaran, Matthew K Leonard, Frederic E Theunissen and Edward F Chang | Summary: Melody is a core component of music in which discrete pitches are serially arranged to convey emotion and meaning. Perception of melody varies along several pitch-based dimensions: (1) the absolute pitch of notes, (2) the […]


Continue.. Encoding of melody in the human auditory cortex

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Kavli Affiliate: Edward Chang | Authors: Sunada Khadka, Yu-Hsi Lin, Jeffrey J Ackroyd, Yi-An Chen, Yanghui Sheng, Wubin Qian, Sheng Guo, Yining Chen, Eliot Itzkow Behr, Yasaman Barekatin, Md. Nasir Uddin, Kenisha Arthur, Victoria C Yan, Edward Chang, Anton Poral, Theresa Tran, Wen-Hao Hsu, Surendra Chaurasiya, Dimitra K. Georgiou, John M. Asara, Floris P. Barthel, […]


Continue.. Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Development of covalent chemogenetic K2P channel activators

Kavli Affiliate: Daniel Minor | Authors: Parker E Deal, Haerim Lee, Abhisek Mondal, Marco Lolicato, Philipe Ribeiro Furtado de Mandonca, Holly Black, Xochina El-Hilali, Clifford Bryant, Ehud Y Isacoff, Adam Renslo and Daniel L Minor, Jr. | Summary: K2P potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune […]


Continue.. Development of covalent chemogenetic K2P channel activators

A Simple Subcortical Feeding Circuit Linking Interoceptive Inputs to Consummatory Behavior

Kavli Affiliate: Zachary Knight & Jeffrey M. Friedman | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: The brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the underlying circuitry linking inputs to outputs is unknown. Here we delineate a subcortical circuit in […]


Continue.. A Simple Subcortical Feeding Circuit Linking Interoceptive Inputs to Consummatory Behavior

Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

Kavli Affiliate: Xin Duan | Authors: Axel Guskjolen, Jagroop Dhaliwal, Juan de la Parra, Jonathan R Epp, Sangyoon Ko, Erin Chahley, Mitch de Snoo, Michela Solari, Prabdeep Panesar, Jason Scott Snyder, Xin Duan, Joshua Sanes, Sheena Josselyn and Paul Frankland | Summary: Post-training increases in hippocampal neurogenesis are associated with forgetting of hippocampus-dependent memories in […]


Continue.. Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting

Developmental origin and local signals cooperate to determine septal astrocyte identity

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Yajun Xie, Christopher M Reid, Alejandro A Granados, Miguel Turrero Garcia, Fiona Dale-Huang, Sarah M Hanson, Walter R Mancia Leon, Jonathan Liu, Manal A Adam, Olivia Mosto, Angela Oliveira Pisco, Arturo Alvarez-Buylla and Corey C Harwell | Summary: Astrocyte specification during development is influenced by both intrinsic and extrinsic […]


Continue.. Developmental origin and local signals cooperate to determine septal astrocyte identity

Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Kavli Affiliate: Michael Stryker | Authors: Wendy Xin, Megumi Kaneko, Richard H Roth, Albert Zhang, Sonia Nocera, Jun B Ding, Michael P Stryker and Jonah R Chan | Summary: BACKGROUND: Developmental myelination is a protracted process in the mammalian brain. One theory for why oligodendrocytes mature so slowly posits that myelination may stabilize neuronal circuits […]


Continue.. Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Unsupervised pattern discovery in spatial gene expression atlas reveals mouse brain regions beyond established ontology

Kavli Affiliate: Reza Abbasi Asl | Authors: Robert Cahill, Yu Wang, Alex Lee, Hongkui Zeng, Bin Yu, Bosiljka Tasic and Reza Abbasi-Asl | Summary: The growth of large-scale spatial gene expression data requires new computational tools to extract major trends in gene expression in their native spatial context. Here, we describe an unsupervised and interpretable […]


Continue.. Unsupervised pattern discovery in spatial gene expression atlas reveals mouse brain regions beyond established ontology

Predicting Long and Short Duration Beta Bursts from Subthalamic Nucleus Local Field Potential Activity in Parkinson’s Disease

Kavli Affiliate: Philip Starr | Authors: Bahman Abdi-Sargezeh, Sepehr Shirani, Abhinav Sharma, Philip Starr, Simon Little and Ashwini Oswal | Summary: Neural activities within the beta frequency range (13-30 Hz) are not stationary, but occur in transient packets known as beta bursts. Parkinson’s disease (PD) is characterized by the occurrence of beta bursts of increased […]


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Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism

Kavli Affiliate: Arnold R. Kriegstein | Authors: Yonatan Perez, Dmitry Velmeshev, Li Wang, Matthew White, Clara Siebert, Jennifer Baltazar, Natalia Garcia Dutton, Shaohui Wang, Maximilian Haeussler, Stormy Chamberlain and Arnold Kriegstein | Summary: Duplication 15q (dup15q) syndrome is the most common genetic cause of autism spectrum disorder (ASD). Due to a higher genetic and phenotypic […]


Continue.. Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism