Adaptive experiments in high-dimensional feature spaces: A particle filtering approach

Kavli Affiliate: Angela Yu | Authors: Rabea Turon, Lars C. Reining, Philipp A. Hummel, Lynn Schmittwilken, Christine Lind, Angela J. Yu, Constantin A. Rothkopf, Frank Jaekel and Thomas S. A. Wallis | Summary: Behavioral experiments are often infeasible when stimulus spaces have many dimensions or when testing time is limited. One way to address this […]


Continue.. Adaptive experiments in high-dimensional feature spaces: A particle filtering approach

Identifying adaptive variation in spatially structured populations using low-coverage whole-genome sequencing data

Kavli Affiliate: Timothy Brown | Authors: Nikunj Goel, Christen M. Bossu, Seorim Yi, Erica C. N. Robertson, Timothy M. Brown, Peri E. Bolton, Ben J. Vernasco, Erika Zavaleta, Kristen C. Ruegg and Mevin B. Hooten | Summary: Successful implementation of evolutionary programs to rescue climatically threatened species requires identification of adaptive variation. Although many genotype-environment […]


Continue.. Identifying adaptive variation in spatially structured populations using low-coverage whole-genome sequencing data

Purification and characterization of recombinant Rtt109, a fungus-specific histone acetyltransferase, from Candida albicans

  Kavli Affiliate: V. S. Ramachandran | Authors: Simran Sharma, Vijayan Ramachandran, Sneha Sudha Komath, Rohini Muthuswami and Samudrala Gourinath | Summary: Epigenetic regulation of chromatin dynamics via histone acetylation is one of several mechanisms by which eukaryotes regulate gene expression, DNA replication and repair, and maintain genome stability. This function is performed by histone […]


Continue.. Purification and characterization of recombinant Rtt109, a fungus-specific histone acetyltransferase, from Candida albicans

Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice

  Kavli Affiliate: Kay Tye | Authors: Reesha Patel, Kelly Kim, Makenzie Patarino, Rachelle Pamintuan, Felix Taschbach, Hao Li, Bitna Joo, Anna Pallé, Xianru Yu, Christopher R Lee, Aniek van Hoek, Jesse White, Rogelio Castro, Christian Cazares, Raymundo Miranda, Caroline Jia, Jeremy Delahanty, Kanha Batra, Laurel Keyes, Avraham Libster, Romy W. Wichmann, Talmo Pereira, Marcus […]


Continue.. Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice

iG6PSnFR: A genetically encoded fluorescent sensor for observing glucose-6-phosphate dynamics in living preparations

  Kavli Affiliate: Timothy Brown | Authors: Jonathan S. Marvin, Anastasia Tsives, Shih Ming Huang, Zhanat Koshenov, Raghabendra Adhikari, Aaron D. Wolfe, Ian J. Gonzalez, Daniel Feliciano, Timothy A. Ryan, Matthew J. Merrins, Daniel A. Colón-Ramos and Timothy A. Brown | Summary: Glucose-6-phosphate (G6P) is a key intermediate in multiple energetic and anabolic pathways, and […]


Continue.. iG6PSnFR: A genetically encoded fluorescent sensor for observing glucose-6-phosphate dynamics in living preparations

Functional Organization of the Neonatal Basal Ganglia and Thalamus

Kavli Affiliate: Deanna J. Greene | Authors: Samantha Lynn Blake, Jeanette K. Kenley, Tara A. Smyser, Aidan Latham, Dimitrios Alexopoulos, Deanna J. Greene, Rachel E. Lean, Deanna M. Barch, Barbara B. Warner, Joan L. Luby, Cynthia E. Rogers, Christopher D. Smyser, Chad M. Sylvester and Ashley N. Nielsen | Summary: The basal ganglia and thalamus […]


Continue.. Functional Organization of the Neonatal Basal Ganglia and Thalamus

Changes in perceptual sampling contribute to representational drift

Kavli Affiliate: John Serences | Authors: Yixin Yuan, John Serences and Mikio Christian Aoi | Summary: Gradual changes in neural response patterns to the same stimulus over time, termed representational drift, have been widely observed across cortical areas. Drift is typically attributed to intrinsic neural dynamics driven by synaptic plasticity or turnover. Here we test […]


Continue.. Changes in perceptual sampling contribute to representational drift

Clinical Relevant Immunosuppressive Drugs Differentially Modulate Axonal Outgrowth from Human Stem Cell Derived Neurons

Kavli Affiliate: Mark H. Tuszynski | Authors: Gunnar H.D. Poplawski, Chase Weinholtz, Grace Woodruff, Ruhel Ahmad, Wyatt Bunner, Rodrigo Gonzales and Mark H. Tuszynski | Summary: Neural stem cell (NSC) transplantation is a promising strategy for repairing the injured spinal cord, but transplanted cells typically require immunosuppressive therapy to prevent rejection—even for induced pluripotent stem […]


Continue.. Clinical Relevant Immunosuppressive Drugs Differentially Modulate Axonal Outgrowth from Human Stem Cell Derived Neurons

A 3D Brain Geometry Toolkit for Multisite Neuroimaging Analysis

Kavli Affiliate: Anders Dale | Authors: Yanghee Im, Melody J.Y. Kang, Boris A. Gutman, Pravesh Parekh, Diliana Pecheva, Anders M. Dale, Ole A. Andreassen, Paul M. Thompson, Christopher R.K. Ching and for the ENIGMA Bipolar Disorder Working Groupz | Summary: Compared to traditional gross volumetrics, surface-based models provide greater spatial precision for understanding brain alterations […]


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Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

Kavli Affiliate: Mark Ellisman | Authors: Zhaoqi Yan, Andrew S Mendiola, Kelli Lauderdale, Keun-Young Kim, Yu Yong, Kun Leng, Eric A Bushong, Renaud Schuck, Anke Meyer-Franke, Ayushi Agrawal, Michela Traglia, Natalie Gill, Reuben Thomas, Jonah N Keller, Nikolaos Karvelas, Miguel F Vasquez, Daniel C Ballard, Matthew Madany, Jeffrey Simms, Brandon Guo, Reshmi Tognatta, Maria del […]


Continue.. Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease