The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States

Kavli Affiliate: Eiman Azim | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sanyal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


Continue.. The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]


Continue.. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Kavli Affiliate: Yishi Jin | Authors: Anjali Sandhu, Xiaohui Lyu, Xinghaoyun Wan, Xuefeng Meng, Ngang Heok Tang, Gilberto Gonzalez, Ishana N Syed, Lizhen Chen, Yishi Jin and Andrew D Chisholm | Summary: Microtubules (MTs) are dynamic components of the cytoskeleton and play essential roles in morphogenesis and maintenance of tissue and cell integrity. Despite recent […]


Continue.. The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

Kavli Affiliate: Mark Ellisman | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform […]


Continue.. AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

Representing the dynamics of natural marmoset vocal behaviors in frontal cortex

Kavli Affiliate: Cory Miller | Authors: Jingwen Li, Mikio Christian Aoi and Cory Miller | Summary: Here we tested the respective contributions of primate premotor and prefrontal cortex to support vocal behavior. We applied a model-based GLM analysis that better accounts for the inherent variance in natural, continuous behaviors to characterize the activity of neurons […]


Continue.. Representing the dynamics of natural marmoset vocal behaviors in frontal cortex

Neurexin drives C. elegans avoidance behavior independently of its post-synaptic binding partner Neuroligin

Kavli Affiliate: Sreekanth Chalasani | Authors: Caroline S Muirhead, Kirthi C Reddy, Sophia Guerra, Michael Rieger, Michael P Hart, Jagan Srinivasan and Sreekanth H Chalasani | Summary: Neurexins and their canonical binding partners, neuroligins, are localized to neuronal pre-, and post-synapses, respectively, but less is known about their role in driving behaviors. Here, we use […]


Continue.. Neurexin drives C. elegans avoidance behavior independently of its post-synaptic binding partner Neuroligin

Astrocyte CCN1 stabilizes neural circuits in the adult brain

Kavli Affiliate: Nicola Allen | Authors: Laura Sancho, Matthew M Boisvert, Trinity Dawoodtabar, Jillybeth Burgado, Ellen Wang and Nicola J Allen | Summary: Neural circuits in many brain regions are refined by experience. Sensory circuits support higher plasticity at younger ages during critical periods – times of circuit refinement and maturation – and limit plasticity […]


Continue.. Astrocyte CCN1 stabilizes neural circuits in the adult brain

A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Kavli Affiliate: John Serences | Authors: Anna Shafer-Skelton, Timothy F Brady and John T Serences | Summary: Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information from co-occurring features and cues (e.g., the 3D shape […]


Continue.. A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

A series of spontaneously blinking dyes for super-resolution microscopy

Kavli Affiliate: Timothy Brown | Authors: Katie L. Holland, Sarah E. Plutkis, Timothy A. Daugird, Abhishek Sau, Jonathan B. Grimm, Brian P. English, Qinsi Zheng, Sandeep Dave, Fariha Rahman, Liangqi Xie, Peng Dong, Ariana N. Tkachuk, Timothy A. Brown, Robert H. Singer, Zhe J. Liu, Catherine G. Galbraith, Siegfried M. Musser, Wesley R. Legant and […]


Continue.. A series of spontaneously blinking dyes for super-resolution microscopy

The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

Kavli Affiliate: Li Zhao | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sayal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


Continue.. The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain