Kavli Affiliate: Yishi Jin | Authors: Dana T Byrd, Ziyuan Christina Han, Christopher A Piggott and Yishi Jin | Summary: PACS (Phosphofurin Acidic Cluster Sorting Protein) proteins are known for their roles in sorting cargo proteins to organelles and can physically interact with WD40 repeat-containing protein WDR37. PACS1, PACS2, and WDR37 variants are associated with […]
Kavli Affiliate: Mark Ellisman | Authors: Marco Uytiepo, Mark Ellisman and Anton Maximov | Summary: Memory engrams are formed through experience-dependent remodeling of neural circuits, but their detailed architectures have remained unresolved. Using 3D electron microscopy, we performed nanoscale reconstructions of the hippocampal CA3-CA1 pathway following chemogenetic labeling of cellular ensembles with a remote history […]
Kavli Affiliate: Eiman Azim | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sanyal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]
Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]
Kavli Affiliate: Yishi Jin | Authors: Anjali Sandhu, Xiaohui Lyu, Xinghaoyun Wan, Xuefeng Meng, Ngang Heok Tang, Gilberto Gonzalez, Ishana N Syed, Lizhen Chen, Yishi Jin and Andrew D Chisholm | Summary: Microtubules (MTs) are dynamic components of the cytoskeleton and play essential roles in morphogenesis and maintenance of tissue and cell integrity. Despite recent […]
Kavli Affiliate: Mark Ellisman | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform […]
Kavli Affiliate: Cory Miller | Authors: Jingwen Li, Mikio Christian Aoi and Cory Miller | Summary: Here we tested the respective contributions of primate premotor and prefrontal cortex to support vocal behavior. We applied a model-based GLM analysis that better accounts for the inherent variance in natural, continuous behaviors to characterize the activity of neurons […]
Kavli Affiliate: Sreekanth Chalasani | Authors: Caroline S Muirhead, Kirthi C Reddy, Sophia Guerra, Michael Rieger, Michael P Hart, Jagan Srinivasan and Sreekanth H Chalasani | Summary: Neurexins and their canonical binding partners, neuroligins, are localized to neuronal pre-, and post-synapses, respectively, but less is known about their role in driving behaviors. Here, we use […]
Kavli Affiliate: Nicola Allen | Authors: Laura Sancho, Matthew M Boisvert, Trinity Dawoodtabar, Jillybeth Burgado, Ellen Wang and Nicola J Allen | Summary: Neural circuits in many brain regions are refined by experience. Sensory circuits support higher plasticity at younger ages during critical periods – times of circuit refinement and maturation – and limit plasticity […]
Kavli Affiliate: John Serences | Authors: Anna Shafer-Skelton, Timothy F Brady and John T Serences | Summary: Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information from co-occurring features and cues (e.g., the 3D shape […]