Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study

Kavli Affiliate: Wesley Thompson | Authors: Lin Li, Mohammadreza Bayat, Timothy Hayes, Wesley K. Thompson, Arianna Morgan Sandmark Gard and Anthony Steven Dick | Summary: This paper addresses the challenges of managing missing values within expansive longitudinal neuroimaging datasets, using the specific example of data derived from the Adolescent Brain and Cognitive Development ABCD study. […]


Continue.. Missing data approaches for longitudinal neuroimaging research: Examples from the Adolescent Brain and Cognitive Development (ABCD) Study

Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

Kavli Affiliate: Mark H. Tuszynski; | Authors: Pabitra K Sahoo, Nick Hanovice, Patricia Ward, Manasi A Agrawal, Terika P Smith, HaoMin SiMa, Jennifer N Dulin, Lauren S Vaughn, Mark Tuszynski, Kristy Welshhans, Larry Benowitz, Arthur English, John D Houle and Jeffery L Twiss | Summary: Depletion or inhibition of core stress granule proteins, G3BP1 in […]


Continue.. Disruption of Core Stress Granule Protein Aggregates Promotes CNS Axon Regeneration

Scalable electron tomography for connectomics

Kavli Affiliate: Mark Ellisman; | Authors: Aaron T Kuan, Sebastien Phan, Keun-Young Kim, Mason Mackey, Minsu Kim, Steven T Peltier, Mark Ellisman and Wei-Chung Allen Lee | Summary: We demonstrate limited-tilt, serial section electron tomography (ET), which can non-destructively map brain circuits over large 3D volumes and reveal high-resolution, supramolecular details within subvolumes of interest. […]


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Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

Kavli Affiliate: Stephan Anagnostaras; | Authors: Joseph Offenberger, Bianca Chen, Leigh-Ana Rossitto, Irisa Jin, Liam Conaboy, Helios Gallego-Gutierrez, Bliss Nelsen, Eduardo Frias-Anaya, David J. Gonzalez, Stephan Anagnostaras and Miguel Alejandro Lopez-Ramirez | Summary: Background Cerebral Cavernous Malformations (CCMs) are neurovascular abnormalities in the central nervous system (CNS) caused by loss of function mutations in KRIT1 […]


Continue.. Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

Interdependence between SEB-3 and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans

Kavli Affiliate: Sreekanth Chalasani | Authors: Kathleen T Quach, Gillian A Hughes and Sreekanth H Chalasani | Summary: Prey must balance the need to avoid predators with the need to feed, a dilemma central to prey refuge theory. Additionally, prey must also assess predatory imminence, or how close predator threats are in space and time. […]


Continue.. Interdependence between SEB-3 and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans

Coumarin as a general switching auxiliary to prepare photochromic and spontaneously blinking fluorophores

Kavli Affiliate: Timothy Brown | Authors: Fadi Jradi, Brian P English, Timothy A Brown, Jesse Arron, Satya Khuon, James A Galbraith, Catherine G Galbraith and Luke D Lavis | Summary: Single-molecule localization microscopy (SMLM) uses activatable or switchable fluorophores to create non-diffraction limited maps of molecular location in biological samples. Despite the utility of this […]


Continue.. Coumarin as a general switching auxiliary to prepare photochromic and spontaneously blinking fluorophores

Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

Kavli Affiliate: Anders Dale | Authors: Diana M. Smith, Pravesh Parekh, Joseph Kennedy, Robert J. Loughnan, Oleksandr Frei, Thomas E. Nichols, Ole A. Andreassen, Terry L. Jernigan and Anders M. Dale | Summary: The relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal […]


Continue.. Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior

Kavli Affiliate: Kay Tye | Authors: Alexander Lin, Cyril Akafia, Olga Dal Monte, Siqi Fan, Nicholas Fagan, Philip Putnam, Kay M. Tye, Steve Chang, Demba Ba and AZA Stephen Allsop; | Summary: In neuroscience, understanding how single-neuron firing contributes to distributed neural ensembles is crucial. Traditional methods of analysis have been limited to descriptions of […]


Continue.. An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior

Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology

Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Nathaniel Noblett, Lauren Pitts, Antonio Colavita, Ann M Wehman, Yishi Jin and Andrew D Chishol/p> | Summary: Mature neurons maintain their distinctive morphology for extended periods in adult life. Compared to developmental neurite outgrowth, axon guidance, and target selection, relatively little is known of mechanisms that maintain […]


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A recurrent network model of planning explains hippocampal replay and human behavior

Kavli Affiliate: Marcelo Mattar | Authors: Kristopher T. Jensen, Guillaume Hennequin and Marcelo G. Mattar | Summary: When interacting with complex environments, humans can rapidly adapt their behavior to changes in task or context. To facilitate this adaptation, we often spend substantial periods of time contemplating possible futures before acting. For such planning to be […]


Continue.. A recurrent network model of planning explains hippocampal replay and human behavior