Kavli Affiliate: Li Zhao | Authors: Qing Guo, Zhao-Feng Li, Dong-Yan Hu, Pei-Jun Li, Kai-Nian Wu, Hui-Hui Fan, Jie Deng, Hong-Mei Wu, Xiong Zhang and Jian-Hong Zhu | Summary: Attention deficit and hyperactivity disorder (ADHD) is a prevalent developmental disorder. SELENOT is an endoplasmic reticulum-resident selenocysteine-containing protein. We aimed to investigate the role of SELENOT […]

Kavli Affiliate: Vanessa Ruta | Authors: Tom Hindmarsh Sten, Rufei Li, Florian Hollunder, Shadé Eleazer and Vanessa Ruta | Summary: Males of many species have evolved behavioral traits to both attract females and repel rivals. Here, we explore mate selection in Drosophila from both the male and female perspective to shed light on how these […]

Kavli Affiliate: Eric D. Siggia | Authors: Archishman Raju and Eric Siggia | Summary: The lineage decision that generates the epiblast and primitive endoderm from the inner cell mass (ICM) is a paradigm for cell fate specification. Recent mathematics has formalized Waddington’s landscape metaphor and proven that lineage decisions in detailed gene network models must […]

Kavli Affiliate: Shai Shaham | Authors: Nikolaos Stefanakis, Jessica Jiang, Yupu Liang and Shai Shaham | Summary: While most CNS glia arise from neuroectodermal progenitors, some, like microglia, are mesodermally derived. To understand mesodermal glia development and function, we investigated C. elegans GLR glia, which ensheath the brain neuropil and separate it from the circulatory-system […]

Kavli Affiliate: A. James Hudspeth | Authors: Camila M. Villasante, Xinyue Deng, Joel E. Cohen and A.J. Hudspeth | Summary: Mechanical force controls the opening and closing of mechanosensitive ion channels atop the hair bundles of the inner ear. The filamentous tip link connecting transduction channels to the tallest neighboring stereocilium modulates the force transmitted […]

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Matthew R Paul, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in Huntington’s disease (HD) cortex, the nature of somatic […]

Kavli Affiliate: Priya Rajasethupathy | Authors: Josue M Regalado, Ariadna Corredera Asensio, Theresa Haunold, Andrew C Toader, Yan Ran Li, Lauren A Neal and Priya Rajasethupathy | Summary: Learning requires the ability to link actions to outcomes. How motivation facilitates learning is not well understood. We designed a behavioral task in which mice self-initiate trials […]

Kavli Affiliate: A. James Hudspeth | Authors: Ryohei Oya, Kwang Min Woo, Brian Fabella, Rodrigo Gogui Alonso and Albert James Hudspeth | Summary: In the receptor organs of the inner ear and lateral line, sensory hair cells detect mechanical stimuli such as sounds, accelerations, and water movements. In each instance a stimulus deflects the hair […]

Kavli Affiliate: Winrich Freiwald | Authors: Ben Deen, Gasi Husain and Winrich A Freiwald | Summary: How does the brain process the faces of familiar people? Neuropsychological studies have argued for an area of the temporal pole (TP) linking faces with person identities, but magnetic susceptibility artifacts in this region have hampered its study with […]

Kavli Affiliate: Leslie B. Vosshall | Authors: Takeshi Morita, Nia G Lyn, Ricarda K von Heynitz, Olivia V Goldman, Trevor R Sorrells, Matthew DeGennaro, Benjamin J Matthews, Leah Houri-Zeevi and Leslie B Vosshall | Summary: Sensory compensation is a process that allows individuals with a loss of one sense, for instance hearing or vision, to […]