Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

Kavli Affiliate: Leslie B. Vosshall and Michael Miller | Authors: Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall and Laura B. Duvall | Summary: Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required […]


Continue.. Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

Overexpression of PpGL2 from Prunus persica enhanced soybean drought tolerance

Kavli Affiliate: Li Zhao | Authors: Wei Li, Dahong Li, Li Zhao and Hongyan Li | Summary: The HD-ZIP transcription factor family plays crucial roles in plant growth and abiotic stress responses. While its diverse functions and regulatory mechanisms are well-documented, its role in conferring abiotic stress tolerance in peaches remains largely unexplored. Here, we […]


Continue.. Overexpression of PpGL2 from Prunus persica enhanced soybean drought tolerance

The Origin and Evolution of Sex Peptide and Sex Peptide Receptor Interactions

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Nicolas Svetec, Henrik Molina and Li Zhao | Summary: Post-mating responses play a vital role in successful reproduction across diverse species. In fruit flies, sex peptide (SP) binds to sex peptide receptor (SPR), triggering a series of post-mating responses. However, the origin of SPR predates the emergence […]


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A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Kavli Affiliate: Alipasha Vaziri | Authors: Yaunlong Zhang, Lekang Yuan, Jiamin Wu, Tobias Noebauer, Rujin Zhang, Guihua Xiao, Mingrui Wang, Hao Xie, Qionghai Dai and Alipasha Vaziri | Summary: Understanding how neuronal dynamics gives rise to ethologically relevant behavior requires recording of neuronal population activity via technologies that are compatible with unconstrained animal behavior. However, […]


Continue.. A Systematically Optimized Miniaturized Mesoscope (SOMM) for large-scale calcium imaging in freely moving mice

Multiple objects evoke fluctuating responses in several regions of the visual pathway

Kavli Affiliate: Winrich Freiwald | Authors: Meredith N Schmehl, Valeria C Caruso, Yunran Chen, Na Young Jun, Shawn M Willett, Jeff T Mohl, Douglas A Ruff, Marlene R Cohen, Akinori Ebihara, Winrich Freiwald, Surya T Tokdar and Jennifer M Groh | Summary: How neural representations preserve information about multiple stimuli is mysterious. Because tuning of […]


Continue.. Multiple objects evoke fluctuating responses in several regions of the visual pathway

A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

Kavli Affiliate: Jean-Laurent Casanova, Charles M. Rice | Authors: Jeremie Le Pen, Gabrielle Paniccia, Michael Bauer, H.-Heinrich Hoffmann, Volker Kinast, Marcela Moncada-Velez, Ana Pinharanda, Inna Ricardo-Lax, Ansgar F Stenzel, Edwin A Rosado-Olivieri, Alison W Ashbrook, Kenneth H Dinnon, William Doyle, Catherine Freije, Seon-Hui Hong, Danyel Lee, Tyler Lewy, Joseph M Luna, Avery Peace, Carltin Schmidt, […]


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Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Kavli Affiliate: Mary E. Hatten | Authors: Michalina Hanzel, Kayla Fernando, Susan E Maloney, Shioaching Gong, Kärt Mätlik, Jiajia Zhao, H Amalia Pasolli, Søren Heissel, Joseph D Dougherty, Court Hull and Mary E Hatten | Summary: Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and […]


Continue.. Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Ryan J Farrell, Kirsten G Bredvik, Michael Blake Hoppa, S Thomas Hennegan, Timothy A Brown and Timothy A Ryan | Summary: The endoplasmic reticulum (ER) is an important regulator of Ca2+ in cells and dysregulation of ER calcium homeostasis can lead to numerous pathologies. Understanding how […]


Continue.. A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions

Using artificial intelligence to document the hidden RNA virosphere

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]


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Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling

Kavli Affiliate: Michael W. Young | Authors: Waruna Thotamune, Sithurandi Ubeysinghe, Kendra Kumar Shrestha, Mahmoud Elhusse Mostafa, Michael C Young and Ajith Karunarathne | Summary: Beta-adrenergic receptors (βARs) are G protein-coupled receptors (GPCRs) that mediate catecholamine-induced stress responses, such as heart rate increase and bronchodilation. In addition to signals from the cell surface, βARs also […]


Continue.. Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling