Kavli Affiliate: Shai Shaham | Authors: Rashna Sharmin, Aladin Elkhalil, Sara Pena, Pranya Gaddipati, Ginger Clark, Pavak K Shah, Mark W Pellegrino, Shai Shaham and Piya Ghose | Summary: Polarized cells (such as neurons), defined by distinct compartments are, like many cell types, subject to developmental elimination, as in neurite pruning. The molecular mechanism behind […]

Kavli Affiliate: Shai Shaham | Authors: Nikolaos Stefanakis, Jasmine Xi, Jessica Jiang and Shai Shaham | Summary: Endothelial cells form the inner layer of blood vessels and play key roles in circulatory system development and function. A variety of endothelial cell types have been described through gene expression and transcriptome studies; nonetheless, the transcriptional programs […]

Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Bing-Jun Wang, Nicolas Svetec and Li Zhao | Summary: The regulation of gene expression is crucial for the functional integration of evolutionarily young genes, particularly those that emerge de novo. However, the regulatory programs governing the expression of de novo genes remain unknown. To address this, we […]

Kavli Affiliate: Roderick MacKinnon | Authors: Venkata Shiva Mandala and Roderick MacKinnon | Summary: Gating in voltage-dependent ion channels is regulated by the transmembrane voltage. This form of regulation is enabled by voltage sensing domains (VSDs) that respond to transmembrane voltage differences by changing their conformation and exerting force on the pore to open or […]

Kavli Affiliate: Robert B. Darnell | Authors: Krithi Irmady, Claudia Scheckel, Ruth A Singer, Thomas Carroll and Robert B Darnell | Summary: The neuronal RNA-binding protein (RBP) family nELAVL regulates key neuronal processes by binding directly to target RNA transcripts. In this study, we demonstrate that ELAVL3 is the predominant nELAVL paralog expressed in D1 […]

Kavli Affiliate: Eric D. Siggia | Authors: Ismail Hajji, Eric D Siggia, Francis Corson and Wolfgang Keil | Summary: During development, cells gradually assume specialized fates via changes of transcriptional dynamics in thousands of genes. Terminal cell identities are then stabilized through the convergence of gene regulatory network dynamics and the accumulation of epigenetic DNA […]

Kavli Affiliate: Gaby Maimon | Authors: Franka H. van der Linden, Stephen C. Thornquist, Rick M. ter Beek, Jelle Y. Huijts, Mark A. Hink, Theodorus W.J. Gadella, Jr., Gaby Maimon and Joachim Goedhart | Summary: Fluorescent biosensors toggle between two states and for the vast majority of biosensors one state is bright and the other […]

Kavli Affiliate: Erich Jarvis | Authors: Matthew Davenport, Ha Na Choe, Hiroaki Matsunami and Erich D Jarvis | Summary: Zebra finches are sexually dimorphic vocal learners. Males learn to sing by imitating mature conspecifics, but females do not. Absence of song in females is associated with atrophy and apparent repression of several vocal learning brain […]

Kavli Affiliate: A. James Hudspeth | Authors: Caleb C. Reagor and A. J. Hudspeth | Summary: Like the sensory organs of the human inner ear, the lateral-line neuromasts (NMs) of fish such as the zebrafish (Danio rerio) contain mechanosensory hair cells (HCs) that are surrounded by progenitors called supporting cells. Damaged NMs can quickly regenerate […]

Kavli Affiliate: Daniel Mucida | Authors: Begüm Aydin, Izabela Mamede, Joana Cardoso, Julia Deere, Yelina Alvarez, Shanshan Qiao, Ved P. Sharma, Marissa A. Scavuzzo, Gregory P. Donaldson, Chun-Jun Guo and Daniel Mucida | Summary: Enteric neurons control gut physiology by regulating peristalsis, nutrient absorption, and secretion. Disruptions in microbial communities caused by antibiotics or enteric […]