Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense

Kavli Affiliate: Jean-Laurent Casanova | Authors: Adam Krebs, Tomi Lazarov, Anthony Reynolds, Kimberly Anne Dill-McFarland, Abigail Xie, James Bean, Muxue Du, Olivier Levy, John Buglino, Aaron Zhong, Anna-Lena Neehus, Stephenie Boisson-Dupuis, Jean-Laurent Casanova, Elouise Elizabeth Kroon, Marlo Moller, Thomas R. Hawn, Ting Zhou, Lydia Finley, Marc-Antoine Jean Juste, Dan Fitzgerald, Frederic Geissmann and Michael S […]


Continue.. Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense

Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish

Kavli Affiliate: A. James Hudspeth | Authors: Rohan S Roy and A. J. Hudspeth | Summary: Peripheral nerve regeneration requires precise selection of the appropriate targets of innervation, often in an environment that differs from that during the developmental wiring of the neural circuit. Severed axons of the zebrafish posterior lateral line nerve have the […]


Continue.. Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish

Neural representation of action symbols in primate frontal cortex

Kavli Affiliate: Winrich Freiwald | Authors: Lucas Y Tian, Kedar U Garzón, Adam G Rouse, Mark AG Eldridge, Marc H Schieber, Xiao-Jing Wang, Joshua B Tenenbaum and Winrich A Freiwald | Summary: At the core of intelligence is proficiency in solving new problems, including those that differ dramatically from problems seen before. Problem-solving, in turn, […]


Continue.. Neural representation of action symbols in primate frontal cortex

Mouse pups lacking a cerebral cortex develop abnormal vocal behavior

Kavli Affiliate: Erich Jarvis | Authors: J. Lomax Boyd, Cesar Vargas and Erich D. Jarvis | Summary: Vocal learning is an essential component of spoken language and critically depends on the cerebral cortex. The evolutionary origins of cortical/pallial control over vocal learning abilities in mammals and songbirds remains largely unknown. For instance, reports conflict on […]


Continue.. Mouse pups lacking a cerebral cortex develop abnormal vocal behavior

Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus

Kavli Affiliate: Li Zhao | Authors: Yuan-Fei Pan, Yong He, Yu-Qi Liu, Yong-Tao Shan, Shu-Ning Liu, Xue Liu, Xiaoyun Pan, Yinqi Bai, Zan Xu, Zheng Wang, Jieping Ye, Edward C. Holmes, Bo Li, Yao-Qing Chen, Zhao-Rong Li and Mang Shi | Summary: Predicting the evolution and function of viruses is a fundamental biological challenge, largely […]


Continue.. Predicting the Evolutionary and Functional Landscapes of Viruses with a Unified Nucleotide-Protein Language Model: LucaVirus

A genetic driver of epileptic encephalopathy impairs gating of synaptic glycolysis

Kavli Affiliate: Timothy A. Ryan | Authors: Zhanat Koshenov, Alexandros C. Kokotos, Lorena Benedetti, Jennifer Lippincott Schwartz and Timothy A. Ryan | Summary: The brain is a disproportionately large consumer of fuel, estimated to expend ∼20% of the whole-body energy budget, and therefore it is critical to adequately control brain fuel expenditures while satisfying its […]


Continue.. A genetic driver of epileptic encephalopathy impairs gating of synaptic glycolysis

Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew

Kavli Affiliate: Erich Jarvis | Authors: William R Thomas, Tanya M Lama, Diana Moreno-Santillan, Marta Farre, Cecilia Baldoni, Linelle Abueg, Jennifer Balacco, Olivier Fedrigo, Giulio Formenti, Nivesh Jain, Jacquelyn Mountcastle, Tatiana Tilley, Alan Tracey, David A Ray, Dina K. N. Dechmann, Dominik von Elverfeldt, John Nieland, Angelique P Corthals, Erich Jarvis and Liliana M Davalos […]


Continue.. Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew

Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Kavli Affiliate: Priya Rajasethupathy | Authors: Andrea Terceros, Celine Chen, Yujin Harada, Tim Eilers, Millennium Gebremedhin, Richard P Koche, Pierre-Jacques Hamard, Roshan Sharma and Priya Rajasethupathy | Summary: The molecular mechanisms that enable memories to persist over long time-scales from days to weeks and months are still poorly understood. To develop insights we created a […]


Continue.. Sequential transcriptional gates in the thalamo-cortical circuit coordinate memory stabilization

Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease

Kavli Affiliate: Nathaniel Heintz | Authors: Matthew Baffuto, Kert Mätlik, Isaac Ilyashov, Maria Esterlita Siantoputri, Hasnahana Chetia, Yurie Harada, Erika Sipos, Paul Darnell, Laura Kus, Thomas Carroll, Douglas Barrows, Christina Pressl, Nicholas Didkovsky and Nathaniel Heintz | Summary: Huntington’s disease (HD) is characterized by neuronal dysfunction and degeneration that varies markedly by brain region and […]


Continue.. Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s disease

An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks

Kavli Affiliate: Charles M. Rice | Authors: Matthew A Cattle, Lauren C Aguado, Samantha Sze, Dylan Yueyang Wang, Thales Papagiannakopoulos, Susan Smith, Charles M Rice, William Matthew Schneider and John T Poirier | Summary: Retrons are a retroelement class found in diverse prokaryotes that can be adapted to augment CRISPR-Cas9 genome engineering technology to efficiently […]


Continue.. An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks