A microglia clonal inflammatory disorder in Alzheimer’s Disease

Kavli Affiliate: Damon Clark | Authors: Parisa A Vaziri, Samuel D McDougle and Damon A Clark | Summary: To discern speech or appreciate music, the human auditory system detects how pitch increases or decreases over time. However, the algorithms used to detect changes in pitch, or pitch motion, are incompletely understood. Here, using psychophysics, computational […]


Continue.. A microglia clonal inflammatory disorder in Alzheimer’s Disease

Complete sequencing of ape genomes

Kavli Affiliate: Erich Jarvis | Authors: DongAhn Yoo, Arang Rhie, Prajna Hebbar, Francesca Antonacci, Glennis A. Logsdon, Steven J. Solar, Dmitry Antipov, Brandon D. Pickett, Yana Safonova, Francesco Montinaro, Yanting Luo, Joanna Malukiewicz, Jessica M. Storer, Jiadong Lin, Abigail N. Sequeira, Riley J. Mangan, Glenn Hickey, Graciela Monfort Anez, Parithi Balachandran, Anton Bankevich, Christine R. […]


Continue.. Complete sequencing of ape genomes

Mechanism of neurodegeneration mediated by clonal inflammatory microglia

Kavli Affiliate: Jean-Laurent Casanova | Authors: Rocio Vicario, Stamatina Fragkogianni, Maria Pokrovskii, Carina Mayer, Estibaliz Lopez-Rodrigo, Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay, Isabelle Plu, Veronique Sazdovitch, Sebastien Heritier, Fleur Cohen-Aubart, Natalia Shor, Makoto Miyara, Florence Nguyen-Khac, Agnes Viale, Ahmed Idbaih, Zahir Amoura, Marc Rosenblum, Haochen Zhang, Elias-Ramzey Karnoub, Palash Sashittal, Akhil […]


Continue.. Mechanism of neurodegeneration mediated by clonal inflammatory microglia

G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

Kavli Affiliate: Mary E. Hatten | Authors: Danielle L. Keahi, Mathijs A. Sanders, Matthew R. Paul, Andrew L.H. Webster, Yin Fang, Tom F. Wiley, Samer Shalaby, Thomas S. Carroll, Settara C. Chandrasekharappa, Carolina Sandoval-Garcia, Margaret L. MacMillan, John E. Wagner, Mary E. Hatten and Agata Smogorzewska | Summary: Biallelic pathogenic variants in the essential DNA […]


Continue.. G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastoma

Distinct pathway for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses

Kavli Affiliate: Charles M. Rice | Authors: Alexandra L. Tse, Cory M. Acreman, Inna Ricardo-Lax, Jacob Berrigan, Gorka Lasso, Toheeb Balogun, Fiona L. Kearns, Lorenzo Casalino, Georgia L. McClain, Amartya Mudry Chandran, Charlotte Lemeunier, Rommie E. Amaro, Charles M. Rice, Rohit K. Jangra, Jason S. McLellan, Kartik Chandran and Emily Happy Miller | Summary: Understanding […]


Continue.. Distinct pathway for evolution of enhanced receptor binding and cell entry in SARS-like bat coronaviruses

Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

Kavli Affiliate: Li Zhao | Authors: Chuwen Zhang, Yong He, Jieni Wang, Tengkai Chen, Federico Baltar, Minjie Hu, Jing Liao, Xi Xiao, Zhao-Rong Li and Xiyang Dong | Summary: Phosphorus is essential for life and critically influences marine productivity. Despite geochemical evidence of active phosphorus cycling in deep-sea cold seep ecosystems, the microbial processes involved […]


Continue.. Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike

Kavli Affiliate: Charles M. Rice | Authors: Alexandra L. Tse, Cory M. Acreman, Inna Ricardo-Lax, Jacob Berrigan, Gorka Lasso, Toheeb Balogun, Fiona L. Kearns, Lorenzo Casalino, Georgia L. McClain, Amartya Mudry Chandran, Charlotte Lemeunier, Rommie E. Amaro, Charles M. Rice, Rohit K. Jangra, Jason S. McLellan, Kartik Chandran and Emily Happy Miller | Summary: The […]


Continue.. Epistasis between N-terminal and receptor-binding domains drives cell entry in a bat coronavirus spike

TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

Kavli Affiliate: Li Zhao | Authors: Aaron W. James, Qizhi Qin, Sowmya Ramesh, Zhao Li, Lingke Zhong, Masnsen Cherief, Mary Archer, Xin Xing, Neelima Thottappillil, Mario Gomez-Salazar, Manyu Zhu, Leslie Chang, Ankit Uniyal, Khadijah Mazhar, Monisha Mittal, Edward F. McCarthy, Carol D. Morris, Benjamin Levi, Yun Guan, Thomas L. Clemens and Theodore J. Price | […]


Continue.. TrkA+ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons

Kavli Affiliate: Timothy A. Ryan; | Authors: Kirsten Bredvik, Charmaine Liu and Timothy A. Ryan | Summary: The ketogenic diet is an effective treatment for drug-resistant epilepsy, but the therapeutic mechanisms are poorly understood. Although ketones are able to fuel the brain, it is not known whether ketones are directly metabolized by neurons on a […]


Continue.. Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons

Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing

Kavli Affiliate: Li Zhao; | Authors: Mingxin Xu, Neelima Thottappillil, Masnsen Cherief, Zhao Li, Manyu Zhu, Xin Xing, Mario Gomez-Salazar, Juliet Mukiri Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Chi Zhang, Xue-Wei Wang, Mary Archer, Yun Guan, Robert J. Tower, Patrick Cahan, Theodore J. Price, Thomas L. Clemens and Aaron W. James | Summary: The profound pain […]


Continue.. Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing