Kavli Affiliate: Erich Jarvis | Authors: Giulio Formenti, Bonhwang Koo, Marco Sollitto, Jennifer Balacco, Nadolina Brajuka, Richard Burhans, Erick Duarte, Alice Maria Giani, Kirsty McCaffrey, Jack A Medico, Eugene W Myers and Erich D Jarvis | Summary: Motivation Large sequencing data sets are produced and deposited into public archives at unprecedented rates. The availability of […]
Kavli Affiliate: Daniel Kronauer | Authors: Kip D Lacy, Jina Lee, Kathryn Rozen-Gagnon, Wei Wang, Thomas S Carroll and Daniel J C Kronauer | Summary: Sex determination is a developmental switch that triggers sex-specific developmental programs. This switch is “flipped” by the expression of genes that promote male- or female-specific development. Many lineages have evolved […]
Kavli Affiliate: Li Zhao | Authors: Haven R Garber, Danwei Wang, Celine Kerros, Hannah C Beird, Xizeng Mao, Nina G Howard, Jianhua Zhang, Jason Roszik, John P Miller, Paul Leonard, Yu Cao, Li Zhao, Xingzhi Song, Sahil Seth, Pei Lin, Huandong Sun, Lisa S St John, Sijie Lu, William Wierda, Issa F Khouri, Karen Clise-Dwyer, […]
Kavli Affiliate: Alipasha Vaziri | Authors: Jason Manley and Alipasha Vaziri | Summary: Animals engaged in naturalistic behavior can exhibit a large degree of behavioral variability even under sensory invariant conditions. Such behavioral variability can include not only variations of the same behavior, but also variability across qualitatively different behaviors driven by divergent cognitive states, […]
Kavli Affiliate: Robert B. Darnell and Nathaniel Heintz | Authors: Ruth A Singer, Veronika Rajchin, Kwanghoon Park, Nathaniel Heintz and Robert B Darnell | Summary: Neuronal diversity and function are intricately linked to the dynamic regulation of RNA metabolism, including splicing, localization, and translation. Electrophysiologic studies of synaptic plasticity, models for learning and memory, are […]
Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]
Kavli Affiliate: Li Zhao | Authors: Qing Zhao, William de Nardo, Ruoyu Wang, Yi Zhong, Umur Keles, Li Na Zhao, Huiyi Tay, Sonia Youhanna, Mengchao Yan, Ye Xie, Youngrae Kim, Sungdong Lee, Rachel Liyu Lim, Guoshou Teo, Pradeep Naraya, Paul R Burton, Volker M Lauschke, Hyungwon Choi, Matthew J Watt and Philipp Kaldis | Summary: […]
Kavli Affiliate: Shai Shaham | Authors: Rashna Sharmin, Aladin Elkhalil, Sara Pena, Pranya Gaddipati, Ginger Clark, Pavak K Shah, Mark W Pellegrino, Shai Shaham and Piya Ghose | Summary: Polarized cells (such as neurons), defined by distinct compartments are, like many cell types, subject to developmental elimination, as in neurite pruning. The molecular mechanism behind […]
Kavli Affiliate: Shai Shaham | Authors: Nikolaos Stefanakis, Jasmine Xi, Jessica Jiang and Shai Shaham | Summary: Endothelial cells form the inner layer of blood vessels and play key roles in circulatory system development and function. A variety of endothelial cell types have been described through gene expression and transcriptome studies; nonetheless, the transcriptional programs […]
Kavli Affiliate: Li Zhao | Authors: Junhui Peng, Bing-Jun Wang, Nicolas Svetec and Li Zhao | Summary: The regulation of gene expression is crucial for the functional integration of evolutionarily young genes, particularly those that emerge de novo. However, the regulatory programs governing the expression of de novo genes remain unknown. To address this, we […]