Electrophysiological correlates of attention in the locus coeruleus – anterior cingulate cortex circuit during the rodent continuous performance test

Posted by klaurent Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Henry L Hallock, Suhaas Adiraju, Jorge Miranda-Barrientos, Jessica M McInerney, Seyun Oh, Adrienne C DeBrosse, Ye Li, Gregory Carr and Keri Martinowich | Summary: Sustained attention, the ability to focus on an activity or stimulus over time, is significantly impaired in many psychiatric disorders, and there remains a major […]


Continue.. Electrophysiological correlates of attention in the locus coeruleus – anterior cingulate cortex circuit during the rodent continuous performance test

Influence of Alzheimer’s disease related neuropathology on local microenvironment gene expression in the human inferior temporal cortex

Posted by klaurent Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Sowmya Parthiban, Madhavi Tippani, Heena R Divecha, Nicholas J Eagles, Jashandeep S Lobana, Stephen R Williams, Michelle Mark, Rahul A Bharadwaj, Joel E Kleinman, Thomas M Hyde, Stephanie C Page, Stephanie C Hicks, Keri Martinowich, Kristen R Maynard and Leonardo Collado-Torres | Summary: Neuropathological lesions in […]


Continue.. Influence of Alzheimer’s disease related neuropathology on local microenvironment gene expression in the human inferior temporal cortex

Regression models for partially localized fMRI connectivity analyses

Posted by klaurent Hopkins

Kavli Affiliate: Martin Lindquist, Brian Caffo | Authors: Bonnie B. Smith, Yi Zhao, Martin A. Lindquist and Brian Caffo | Summary: Brain functional connectivity analysis of resting-state functional magnetic resonance imaging (fMRI) data is typically performed in a standardized template space assuming consistency of connections across subjects. This can come in the form of one-edge-at-a-time […]


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Artificial intelligence redefines RNA virus discovery

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]


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Using rare genetic mutations to revisit structural brain asymmetry

Posted by klaurent Hopkins

Kavli Affiliate: David Linden | Authors: Jakub Kopal, Kuldeep Kumar, Kimia Shafighi, Karin Saltoun, Claudia Modenato, Clara A. Moreau, Guillaume Huguet, Martineau Jean-Louis, Charles-Olivier Martin, Zohra Saci, Nadine Younis, Elise Douard, Khadije Jizi, Alexis Beauchamp-Chatel, Leila Kushan, Ana I. Silva, Marianne B. M. van den Bree, David E. J. Linden, Michael J. Owen, Jeremy Hall, […]


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Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-typespecific vulnerabilities in human brain organoids

Posted by klaurent Hopkins

Kavli Affiliate: Jin Kang | Authors: ChangHui Pak, Rebecca Sebastian, Kang Jin, Narciso Pavon, Ruby Bansal, Andrew Potter, Yoonjae Song, Juliana Babu, Rafael Gabriel, Yubing Sun and Bruce J Aronow | Summary: De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions […]


Continue.. Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-typespecific vulnerabilities in human brain organoids

Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel Mucida, Elaine Fuchs | Authors: Sandra Nakandakari-Higa, Maria Cecilia Campos Canesso, Sarah Walker, Aleksey Chudnovskiy, Johanne T Jacobsen, S. Martina Parigi, Karol Fiedorczuk, Elaine Fuchs, Angelina M Bilate, Giulia Pasqual, Daniel Mucida, Yuri Pritykin and Gabriel D Victora | Summary: Cellular interactions are essential for tissue organization and functionality. In particular, immune […]


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Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance

Posted by klaurent Hopkins

Kavli Affiliate: Patricia Janak | Authors: Kurt M Fraser, Bridget J Chen and Patricia H Janak | Summary: Separable striatal circuits have unique functions in Pavlovian and instrumental behaviors but how these roles relate to performance of sequences of actions with and without associated cues is less clear. Here we tested whether dopamine release and […]


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Complex spikes perturb movements, revealing the sensorimotor map of Purkinje cells

Posted by klaurent Hopkins

Kavli Affiliate: Reza Shadmehr | Authors: Salomon Zev Muller, Jay S Pi, Paul Hage, Mohammad Amin Fakharian, Ehsan Sedaghat-Nejad and Reza Shadmehr | Summary: The cerebellar cortex performs computations that are critical for control of our actions, and then transmits that information via simple spikes of Purkinje cells (P-cells) to downstream structures. However, because P-cells […]


Continue.. Complex spikes perturb movements, revealing the sensorimotor map of Purkinje cells

Axon initial segment GABA inhibits action potential generation throughout periadolescent development

Posted by klaurent UCSF

Kavli Affiliate: Kevin Bender | Authors: Anna M Lipkin and Kevin J Bender | Summary: Neurons are remarkably polarized structures: dendrites spread and branch to receive synaptic inputs while a single axon extends and transmits action potentials to downstream targets. Neuronal polarity is maintained by the axon initial segment (AIS), a region between the soma […]


Continue.. Axon initial segment GABA inhibits action potential generation throughout periadolescent development