Kavli Affiliate: Stanley Prusiner | Authors: Gregory E. Merz, Matthew J. Chalkley, Sophia Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado and Daniel R. Southworth | Summary: Abstract Neurodegenerative diseases (NDs) are characterized by the formation of amyloid filaments that adopt disease-specific conformations in the brain. Recently developed small […]
Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: Abstract NMDA receptor autoimmune encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause behavioral and neurologic deficits. Although many symptoms are responsive to immunotherapy, […]
Kavli Affiliate: Daniel S. Mucida | Authors: Leah A Gates, Bernardo Sgarbi Reis, Peder J Lund, Matthew R Paul, Marylene Leboeuf, Zara Nadeem, Thomas S Carroll, Benjamin Garcia, Daniel Mucida and C. David Allis | Summary: SUMMARY Posttranslational modifications (PTMs) on histone proteins are a key source of regulation on chromatin through impacting genome organization […]
Kavli Affiliate: Dwight Bergles | Authors: Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles and Peter A Calabresi | Summary: Abstract Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown […]
Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Hyeon-Cheol Park, Haolin Zhang and Xingde Li | Summary: Abstract Two-photon fluorescence microscopy has enjoyed its wide adoption in neuroscience. Head-mounted miniaturized fiberscopes offered an exciting opportunity for enabling neural imaging in freely-behaving animals with high 3D resolution. Here we propose a dual-fiberscope rotary joint based on […]
Kavli Affiliate: Samuel Pfaff | Authors: Lydia Daboussi, Giancarlo Costaguta, Miriam Gullo, Veronica Pessino, Brendan O’Leary, Karen Lettieri, Shawn Driscoll and Samuel L. Pfaff | Summary: Abstract Schwann cells respond to acute axon damage by transiently transdifferentiating into specialized repair cells that restore sensorimotor function. However, the molecular systems controlling repair cell formation and function […]
Kavli Affiliate: Michael Miller | Authors: Han Zhu, Gaowei Wang, Kim-Vy Nguyen-Ngoc, Dongsu Kim, Michael Miller, Georgina Goss, Jenna Kovsky, Austin R Harrington, Diane Saunders, Rebecca Melton, Alvin C Powers, Sebastian Preissl, Francesca M Spagnoli, Kyle J Gaulton and Maike Sander | Summary: Abstract Pancreatic islet cells derived from human pluripotent stem cells hold great […]
Kavli Affiliate: Mark Ellisman | Authors: Hugo Calligaro, Azarin Shoghi, Xinyue Chen, Keun-Young Kim, Yu Hsin Liu, Brian Khov, Benjamin Finander, Hiep Le, Mark H Ellisman and Satchidananda Panda | Summary: Abstract The suprachiasmatic nucleus (SCN) in the hypothalamus of the vertebrate brain is the central pacemaker regulating circadian rhythmicity throughout the body. The SCN […]
Kavli Affiliate: Fred Gage | Authors: Sarah L Parylak, Fan Qiu, Sara B Linker, Iryna S Gallina, Christina K Lim, David Preciado, Aidan H McDonald and Fred H Gage | Summary: Abstract Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus function. Although […]
Kavli Affiliate: Vy Thuy Nguyen | Authors: Mollie Friedlander Qian, Romina J Bevacqua, Vy M Nguyen, Xiong Liu, Weichen Zhao, Charles A Chang, Xueying Gu, Xiao-Qing Dai, Patrick E Macdonald and Seung K. Kim | Summary: ABSTRACT HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-MODY) and hypomorphic HNF1A variants confer type […]