Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

Posted by klaurent Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Louise A. Huuki-Myers, Abby Spangler, Nicholas J. Eagles, Kelsey D. Montgomery, Sang Ho Kwon, Boyi Guo, Melissa Grant-Peters, Heena R. Divecha, Madhavi Tippani, Chaichontat Sriworarat, Annie B. Nguyen, Prashanthi Ravichandran, Matthew N. Tran, Arta Seyedian, PsychENCODE Consortium, Thomas M. Hyde, Joel E. Kleinman, Alexis Battle, Stephanie C. Page, Mina […]


Continue.. Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

Vulture: Cloud-enabled scalable mining of microbial reads in public scRNA-seq data

Posted by klaurent UCSF

Kavli Affiliate: Xin Duan | Authors: Junyi Chen, Danqing Yin, Harris Y. H. Wong, Xin Duan, Ken H. O. Yu and Joshua W. K. Ho | Summary: The rapidly growing collection of public single-cell sequencing data have become a valuable resource for molecular, cellular and microbial discovery. Previous studies mostly overlooked detecting pathogens in human […]


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Mapping Neurophysiological Subtypes of Major Depressive Disorder Using Normative Models of the Functional Connectome

Posted by klaurent Hopkins

Kavli Affiliate: Xiaoqin Wang | Authors: Xiaoyi Sun, Jin Liu, Qing Ma, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Wenxu Wang, Yong […]


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Genomic, genetic and phylogenetic evidence for a new falcon species using chromosome-level genome assembly of the gyrfalcon and population genomics

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Farooq Omar Al-Ajli, Giulio Formenti, Olivier Fedrigo, Alan Tracey, Ying Sims, Kerstin Howe, Ikdam Karkhi, Asmaa Althani, Erich Jarvis, Sadequr Rahman and Qasim Ayub | Summary: The taxonomic classification of a falcon population found in the Altai region in Asia has been heavily debated for two centuries and previous […]


Continue.. Genomic, genetic and phylogenetic evidence for a new falcon species using chromosome-level genome assembly of the gyrfalcon and population genomics

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

Posted by klaurent Columbia

Kavli Affiliate: Elizabeth Hillman | Authors: Dena Goldblatt, Stephanie Huang, Marie R. Greaney, Kyla R. Hamling, Venkatakaushik Voleti, Citlali Perez-Campos, Kripa B. Patel, Wenze Li, Elizabeth M. C. Hillman, Martha W. Bagnall and David Schoppik | Summary: Abstract Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, […]


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Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

Posted by klaurent Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Agnik Dasgupta, Caleb C. Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo and Albert Hudspeth | Summary: In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory […]


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MISPEL: A deep learning approach for harmonizing multi-scanner matched neuroimaging data

Posted by klaurent Hopkins

Kavli Affiliate: Ciprian Crainiceanu | Authors: Mahbaneh Eshaghzadeh Torbati, Davneet S Minhas, Charles M Laymon, Pauline Maillard, James D Wilson, Chang-Le Chen, Ciprian M Crainiceanu, Charles S DeCarli, Seong Jae Hwang and Dana L Tudorascu | Summary: Abstract Large-scale data obtained from aggregation of already collected multi-site neuroimaging datasets has been brought benefits such as […]


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A quick and cost-effective method for DNA-free total RNA isolation using magnetic silica beads

Posted by klaurent Columbia

Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Debojyoti Das, Arundhati Das and Amaresh Chandra Panda | Summary: Current RNA purification methods widely use silica-based columns that allow quick isolation of high-quality and good quantities of RNA. However, the major limitations include high cost, the requirement of different kits for small RNA isolation, genomic DNA […]


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Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito

Posted by klaurent Columbia

Kavli Affiliate: Scott Small | Authors: Scott T. Small, Carlo Costantini, N’Fale Sagnon, Moussa W. Guelbeogo, Scott J. Emrich, Andrew D. Kern, Michael C. Fontaine and Nora J. Besansky | Summary: Species distributed across heterogeneous environments often evolve locally adapted ecotypes, but understanding of the genetic mechanisms involved in their formation and maintenance in the […]


Continue.. Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito

Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

Posted by klaurent Rockefeller

Kavli Affiliate: Robert B. Darnell | Authors: Leena Ali Ibrahim, Brie Wamsley, Norah Alghamdi, Nusrath Yusuf, Elaine Sevier, Ariel Hairston, Mia Sherer, Xavier Hubert Jaglin, Qing Xu, Lijua Gao, Alireza Khodadadi-Jamayran, Emilia Favuzzi, Yuan Yuan, Jordane Dimidschstein, Robert Darnell and Gordon Fishell | Summary: Somatostatin interneurons are the earliest born population of cortical inhibitory cells. […]


Continue.. Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing