Multiplexed and scalable cellular phenotyping toward the standardized three-dimensional human neuroanatomy

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami and Nathaniel Heintz | Summary: Abstract The advent of three-dimensional histological methods has advanced studies of cellular-resolution anatomy of the brain. The use of whole-mount staining and tissue clearing has advanced systems-level identification of cells underlying brain functions in mouse models. However, application of these methods […]


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Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: José Luis López, Nikolaos Pappas, Sanne WM Poppeliers, Juan J. Sanchez-Gil, Arista Fourie-Fouche, Ronnie de Jonge and Bas E. Dutilh | Summary: Abstract The structure and function of the root microbial community is shaped by plant root activity, enriching specific microbial taxa and functions from the surrounding soil […]


Continue.. Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Multiplexed selectivity screening of anti-GPCR antibodies

Posted by klaurent Rockefeller

Kavli Affiliate: Thomas P. Sakmar | Authors: Leo Dahl, Ilana Kotliar, Annika Bendes, Tea Dodig-Crnkovic, Samuel Fromm, Arne Elofsson, Mathias Uhlen, Thomas P Sakmar and Jochen Schwenk | Summary: Abstract G protein-coupled receptors (GPCRs) control critical cellular signaling pathways. Therapeutic agents, such as antibodies (Abs), are being developed to modulate GPCR signaling pathways. However, validating […]


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Environmental and genetic drivers of population differences in SARS-CoV-2 immune responses

Posted by klaurent Rockefeller

Kavli Affiliate: Jean Laurent Casanova | Authors: Yann Aquino, Aurélie Bisiaux, Zhi Li, Mary O’Neill, Javier Mendoza-Revilla, Sarah Hélène Merkling, Gaspard Kerner, Milena Hasan, Valentina Libri, Vincent Bondet, Nikaïa Smith, Camille de Cevins, Mickaël M Ménager, Francesca Luca, Roger Pique-Regi, Giovanna Barba-Spaeth, Stefano Pietropaoli, Olivier Schwartz, Geert Leroux-Roels, Cheuk-Kwong Lee, Kathy Leung, Joseph T.K. Wu, […]


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Factors governing attachment of Rhizobium leguminosarum to legume roots

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Jack Parsons, Clare Cocker, Alison East, Rachel Wheatley, Vinoy Ramachandran, Farnusch Kaschani, Markus Kaiser and Philip Poole | Summary: Abstract Primary attachment of rhizobia to host legume roots depends on pH and is the first physical interaction during nodulation. Genome-wide insertion sequencing, luminescence-based attachment assays and proteomic analysis […]


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Subcellular niche segregation of co-obligate symbionts in whiteflies

Posted by klaurent UCSD / Salk

Kavli Affiliate: Ying Meng | Authors: Akiko FUJIWARA, Xian-Ying Meng, Yoichi Kamagata and Tsutomu TSUCHIDA | Summary: Abstract Many insects contain endosymbiotic bacteria within their bodies. In multiple endosymbiotic systems comprising two or more symbionts, each of the symbionts is generally localized in a different host cell or tissue. Bemisia tabaci （Sweet potato whitefly）possesses a […]


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Quadratic computations maintain neural specificity to natural stimuli across stages of visual processing

Posted by klaurent UCSD / Salk

Kavli Affiliate: Tatyana Sharpee | Authors: Ryan J. Rowekamp and Tatyana Sharpee | Summary: Abstract Despite recent successes in machine vision, artificial recognition systems continue to be less robust than biological systems. The brittleness of artificial recognition system has been attributed to the linearity of the core operation that matches inputs to target patterns at […]


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Divergent impacts of C9orf72 repeat expansion on neurons and glia in ALS and FTD

Posted by klaurent UCSD / Salk

Kavli Affiliate: Eran Mukamel | Authors: Junhao Li, Manoj K Jaiswal, Jo-Fan Chien, Alexey Kozlenkov, Ping Zhou, Mahammad Gardashli, Luc J Pregent, Erica Engelberg-Cook, Dennis W Dickson, Veronique V Belzil, Eran A Mukamel and Stella Dracheva | Summary: Abstract Neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are strongly influenced by […]


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Identifying genes and pathways linking astrocyte regional specificity to Alzheimer’s disease susceptibility

Posted by klaurent Hopkins

Kavli Affiliate: Paul Greengard | Authors: Ran Zhang, Margarete Knudsen, Pedro Del Cioppo Vasques, Alicja Tadych, Patricia Rodriguez-Rodriguez, Paul Greengard, Jean-Pierre Roussarie, Ana Milosevic and Olga G. Troyanskaya | Summary: Abstract Astrocytes have been shown to play a central role in Alzheimer’s Disease (AD). However, the genes and biological pathways underlying disease manifestation are unknown, […]


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An open-access EEG dataset for speech decoding: Exploring the role of articulation and coarticulation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: João Pedro Carvalho Moriera, Vinícius Rezende Carvalho, Eduardo Mazoni Andrade Marçal Mendes, Aria Fallah, Terrence J. Sejnowski, Claudia Lainscsek and Lindy B Comstock | Summary: Abstract Electroencephalography (EEG) holds promise for brain-computer interface (BCI) devices as a non-invasive measure of neural activity. With increased attention to EEG-based BCI systems, […]


Continue.. An open-access EEG dataset for speech decoding: Exploring the role of articulation and coarticulation