Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease

Posted by klaurent Rockefeller

Kavli Affiliate: Charles Rice | Authors: Rachel Yamin, Kevin S Kao, Margaret R MacDonald, Tineke Cantaert, Charles M Rice, Jeffrey V Ravetch and Stylianos Bournazos | Summary: Abstract Although dengue virus (DENV) infection typically causes asymptomatic disease, DENV-infected patients can experience severe complications. A risk factor for symptomatic disease is pre-existing anti-DENV IgG antibodies. Cellular […]


Continue.. Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease

The molecular genetic landscape of human brain size variation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Eric Courchesne | Authors: Jakob Seidlitz, Travis T. Mallard, Jacob W. Vogel, Younga H. Lee, Varun Warrier, Gareth Ball, Oskar Hansson, Leanna M. Hernandez, Ayan S. Mandal, Konrad Wagstyl, Michael V. Lombardo, Eric Courchesne, Joseph T. Glessner, Theodore D. Satterthwaite, Richard A.I. Bethlehem, Lifespan Brain Chart Consortium, Shinya Tasaki, Bernard Ng, Chris Gaiteri, […]


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An inhibitory plasticity mechanism for world structure inference by hippocampal replay

Posted by klaurent Columbia

Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Darian Hadjiabadi, Satoshi Terada, Ivan Soltesz and Attila Losonczy | Summary: Summary Memory consolidation assimilates recent experiences into long-term memory. This process requires the replay of learned sequences, though the content of these sequences remains controversial. Recent work has shown that the statistics of replay deviate from […]


Continue.. An inhibitory plasticity mechanism for world structure inference by hippocampal replay

A Biophysical Basis for Learning and Transmitting Sensory Predictions

Posted by klaurent Columbia

Kavli Affiliate: Larry Abbott, Nathaniel Sawtell | Authors: Salomon Zev Muller, Larry F Abbott and Nathaniel B Sawtell | Summary: Abstract Homeostatic (anti-Hebbian) forms of synaptic are effective at eliminating “prediction errors” that signal the differences between predicted and actual sensory input. However, such mechanisms appear to preclude the possibility of transmitting the resulting predictions […]


Continue.. A Biophysical Basis for Learning and Transmitting Sensory Predictions

Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles, Patrick Kanold | Authors: Calvin J Kersbergen, Travis A Babola, Patrick O Kanold and Dwight E Bergles | Summary: ABSTRACT Intrinsically generated neural activity propagates through the developing auditory system to promote maturation and refinement of sound processing circuits prior to hearing onset. This early patterned activity is induced by non-sensory […]


Continue.. Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

The BRAIN Initiative Cell Census Data Ecosystem: A User’s Guide

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: BICCN Data Ecosytem Collaboration, Michael J Hawrylycz, Maryann E Martone, Patrick R Hof, Ed S Lein, Aviv Regev, Giorgio A. A Ascoli, Jan G Bjaalie, Hong-Wei Dong, Satrajit S Ghosh, Jesse Gillis, Ronna Hertzano, David R Haynor, Yongsoo Kim, Yufeng Liu, Jeremy A Miller, Partha P Mitra, Eran Mukamel, […]


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Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

Posted by klaurent NTNU

Kavli Affiliate: Vy Thuy Nguyen | Authors: Kim Vy Nguyen Ngoc, Somesh Sai, Yesl Jun, R. Hugh F. Bender, Vira Kravets, Han Zhu, Christopher J Hatch, Michael Schlichting, Roberto Gaetani, Medhavi Mallick, Stephanie J Hachey, Karen Christman, Steven Carl George, Christopher C Hughes and Maike Sander | Summary: Abstract Blood vessels play a critical role […]


Continue.. Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

Posted by klaurent Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Eleftheria Koropouli, Qiang Wang, Rebeca Mejias-Estevez, Randal Hand, Tao Wang, David D Ginty and Alex L Kolodkin | Summary: ABSTRACT Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the elaboration […]


Continue.. Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

Amygdalostriatal transition zone neurons encode sustained valence to direct conditioned behaviors

Posted by klaurent UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: Fergil Mills, Christopher R Lee, James R Howe, Hao Li, Shan Shao, Maria N Keisler, Mackenzie E Lemieux, Felix H Taschbach, Laurel R Keyes, Matilde R Borio, Hannah S Chen, Reesha R. Patel, Alexa L Gross, Jeremy Delahanty, Christian Cazares, Liezl Maree, Romy Wichmann, Talmo D Pereira, Marcus K […]


Continue.. Amygdalostriatal transition zone neurons encode sustained valence to direct conditioned behaviors

Spike-phase coupling patterns reveal laminar identity in primate cortex

Posted by klaurent UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Zachary W Davis, Nicholas M Dotson, Tom Franken, Lyle Muller and John Reynolds | Summary: Abstract The cortical column is one of the fundamental computational circuits in the brain. In order to understand the role neurons in different layers of this circuit play in cortical function it is necessary […]


Continue.. Spike-phase coupling patterns reveal laminar identity in primate cortex