The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Kavli Affiliate: Angela Yu | Authors: Liang Liu, Angela M Yu, Xiuye Wang, Lindsey V. Soles, Yiling Chen, Yoseop Yoon, Kristianna S.K. Sarkan, Marielle Cárdenas Valdez, Johannes Linder, Ivan Marazzi, Zhaoxia Yu, Feng Qiao, Wei Li, Georg Seelig and Yongsheng Shi | Summary: JTE-607 is a small molecule compound with anti-inflammation and anti-cancer activities. Upon […]


Continue.. The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Perirhinal Cortex Learns A Predictive Map of The Task Environment

Kavli Affiliate: Stefano Fusi | Authors: David G. Lee, Caroline A. McLachlan, Ramon Nogueira, Osung Kwon, Alanna E. Carey, Garrett House, Gavin D. Lagani, Danielle LaMay, Stefano Fusi and Jerry L. Chen | Summary: Goal-directed tasks involve acquiring an internal model, known as a predictive map, of relevant stimuli and associated outcomes to guide behavior. […]


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Do perineuronal nets stabilize the engram of a synaptic circuit?

Kavli Affiliate: Mark Ellisman | Authors: Varda Lev-Ram, Sakina Palida, Thomas J Deerinck, Eric A Bushong, Brandon H Toyoma, Alex Perez, Daniel B McClatchy, Denise R Prichard, Jeffrey N Savas, Mark H Ellisman, John Robert Yates III and Roger Y Tsien | Summary: Perineuronal nets (PNN), a specialized form of ECM, surround numerous neurons in […]


Continue.. Do perineuronal nets stabilize the engram of a synaptic circuit?

Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortex

Kavli Affiliate: Michael Miller, Edward Callaway | Authors: Nathan R Zemke, Ethan J Armand, Wenliang Wang, Seoyeon Lee, Jingtian Zhou, Yang Eric Li, Hanqing Liu, Wei Tian, Joseph R Nery, Rosa G Castanon, Anna Bartlett, Julia K Osteen, Daofeng Li, Xiaoyu Zhuo, Vincent Xu, Michael Miller, Fenna M Krienen, Qiangge Zhang, Naz Taskin, Jonathan Ting, […]


Continue.. Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortex

A brain atlas of the camouflaging dwarf cuttlefish, Sepia bandensis

Kavli Affiliate: Richard Axel | Authors: Tessa G. Montague, Isabelle J. Rieth, Sabrina Gjerswold-Selleck, Daniella Garcia-Rosales, Sukanya Aneja, Dana Elkis, Nanyan Zhu, Sabrina Kentis, Frederick A. Rubino, Adriana Nemes, Katherine Wang, Luke A. Hammond, Roselis Emiliano, Rebecca A. Ober, Jia Guo and Richard Axel | Summary: The coleoid cephalopods (cuttlefish, octopus, and squid) are a […]


Continue.. A brain atlas of the camouflaging dwarf cuttlefish, Sepia bandensis

Frugivory and seed predation of fishtail palm (Caryota mitis Lour.) on the remote oceanic island of Narcondam, India

Kavli Affiliate: V. S. Ramachandran | Authors: Abhishek Gopal, Sartaj Ghuman, Navendu Page, Vivek Ramachandran and Rohit Naniwadekar | Summary: Oceanic islands, due to their evolutionary history and isolation, hold a disproportionately high proportion of endemic species. However, their evolutionary history also makes them vulnerable to extinctions, with most known extinctions occurring on islands. Plant-animal […]


Continue.. Frugivory and seed predation of fishtail palm (Caryota mitis Lour.) on the remote oceanic island of Narcondam, India

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

Kavli Affiliate: Mark Ellisman | Authors: Tylor R Lewis, Sebastien Phan, Carson M Castillo, Keun-Young Kim, Kelsey Coppenrath, William Thomas, Ying Hao, Nikolai P Skiba, Marko E Horb, Mark H Ellisman and Vadim Y Arshavsky | Summary: The first steps of vision take place within a stack of tightly packed disc-shaped membranes, or “discs”, located […]


Continue.. Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

Structured memory representations develop at multiple time scales in hippocampal-cortical networks

Kavli Affiliate: Anastasia Kiyonaga | Authors: Arielle Tambini, Jacob Miller, Luke Ehlert, Anastasia Kiyonaga and Mark D’Esposito | Summary: Influential views of systems memory consolidation posit that the hippocampus rapidly forms representations of specific events, while neocortical networks extract regularities across events, forming the basis of schemas and semantic knowledge. Neocortical extraction of schematic memory […]


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CellCover Defines Conserved Cell Types and Temporal Progression in scRNA-seq Data across Mammalian Neocortical Development

Kavli Affiliate: Donald Geman, Laurent Younes | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Accurate identification of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. Such analyses […]


Continue.. CellCover Defines Conserved Cell Types and Temporal Progression in scRNA-seq Data across Mammalian Neocortical Development

3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle

Kavli Affiliate: Elena Gracheva | Authors: Yury A Nikolaev, Luke H Ziolkowski, Song Pang, Wei-Ping Li, Viktor V Feketa, C Shan Xu, Elena O Gracheva and Sviatoslav N Bagriantsev | Summary: Mechanosensory corpuscles detect transient touch and vibratory signals in the skin of vertebrates, enabling navigation, foraging, and precise manipulation of objects1. The corpuscle core […]


Continue.. 3D architecture and a bi-cellular mechanism of touch detection in mechanosensory corpuscle