Kavli Affiliate: Michael Keiser | Authors: Daniel R. Wong, Shino D. Magaki, Harry V. Vinters, William H. Yong, Edwin S. Monuki, Christopher K. Williams, Alessandra C. Martini, Charles DeCarli, Chris Khacherian, John P. Graff, Brittany N. Dugger and Michael J. Keiser | Summary: Precise, scalable, and quantitative evaluation of whole slide images is crucial in […]
Kavli Affiliate: Angela Wu | Authors: Zachary N Harris, Julia E Pratt, Laszlo G Kovacs, Laura L Klein, Misha T Kwasniewski, Jason P Londo, Angela Wu and Allison J Miller | Summary: BACKGROUND Grafting is a horticultural practice used widely across woody perennial crop species to fuse together the root and shoot system of two […]
Kavli Affiliate: Hal Blumenfeld | Authors: Kate L. Christison-Lagay, Noah C. Freedman, Christopher Micek, Aya Khalaf, Sharif I. Kronemer, Mariana M. Gusso, Lauren Kim, Sarit Forman, Julia Ding, Mark Aksen, Ahmad Abdel-Aty, Hunki Kwon, Noah Markowitz, Erin Yeagle, Elizabeth Espinal, Jose Herrero, Stephan Bickel, James Young, Ashesh Mehta, Kun Wu, Jason Gerrard, Eyiyemisi Damisah, Dennis […]
Kavli Affiliate: Pietro DeCamilli, Kenneth Miller | Authors: Junhyun Park, Kenneth G. Miller, Pietro De Camilli and Shaul Yogev | Summary: Axonal transport is key to neuronal function. Efficient transport requires specific motor-cargo association in the soma, yet the mechanisms regulating this early step remain poorly understood. We found that EBP-1, the C. elegans ortholog […]
Kavli Affiliate: Jeremy Nathans | Authors: Jie Wang, Amir Rattner and Jeremy Nathans | Summary: Bacterial meningitis is a major cause of morbidity and mortality, especially among infants and the elderly. Here we study mice to assess the response of each of the major meningeal cell types to early postnatal E. coli infection using single […]
Kavli Affiliate: Jill Leutgeb | Authors: Markos Athanasiadis, Stefano Masserini, Li Yuan, Dustin Fetterhoff, Jill K Leutgeb, Stefan Leutgeb and Christian Leibold | Summary: Remembering what just happened is a crucial prerequisite to form long-term memories but also for establishing and maintaining working memory. So far there is no general agreement about cortical mechanisms that […]
Kavli Affiliate: Damon Clark | Authors:Ryosuke Tanaka, Baohua Zhou, Margarida Agrochao, Bara A. Badwan, Braedyn Au, Natalia C. B. Matos and Damon A. Clark | Summary: In selecting a behavior, animals should weigh sensory evidence both for and against their beliefs about the world. For instance, animals use optic flow to estimate and control their […]
Kavli Affiliate: Denis Wirtzr | Authors:Adrian C. Johnston, Gretchen M. Alicea, Cameron C. Lee, Payal V. Patel, Eban A. Hanna, Eduarda Vaz, Andre Forjaz, Zeqi Wan, Praful R. Nair, Yeongseo Lim, Tina Chen, Wenxuan Du, Dongjoo Kim, Tushar D. Nichakawade, Vito W. Rebecca, Challice L. Bonifant, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu and Denis […]
Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie and Stephen M. Strittmatter | Summary: Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that […]
Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]