Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in the Huntington’s disease (HD) cortex, the nature of somatic CAG expansion […]
Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, David A Davis, Matthew R Paul, Thomas S Carroll and Nathaniel Heintz | Summary: Tissue-specific somatic expansion of the mutant Huntingtin (mHTT) CAG tract and regional degeneration of the brain are key features of Huntington’s disease (HD). However, the relationships between somatic CAG […]
Kavli Affiliate: Loyal Goff | Authors: Debamitra Das, Shreyash Sonthalia, Genevieve G Stein-O’Brien, Marah Wahbeh, Kyra Feuer, Loyal Goff, Carlo Colantuoni, Vasiliki Machairaki and Dimitrios Avramopoulos | Summary: Trans-differentiation of human induced pluripotent stem cells into neurons via Ngn2-induction (hiPSC-N) has become an efficient system to quickly generate neurons for disease modeling and in vitro […]
Kavli Affiliate: Robert Edwards | Authors: Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Hu, Anna Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, Ken Chen, Benedikt Nilges, Nachiket Kashikar, Oliver Braubach, Bassem Cheikh, Nadya Nikulina, Hui Chen, Mediate Teshome, Brian Menegaz, Huma […]
Kavli Affiliate: Robert Edwards | Authors: Jody C McKerral, Bhavya Nalagampalli Papudeshi, Laura K Inglis, Michael J Roach, Przemyslaw Decewicz, Katelyn McNair, Antoni Luque, Elizabeth A Dinsdale and Robert A Edwards | Summary: Phages dominate every ecosystem on the planet. While virulent phages sculpt the microbiome by killing their bacterial hosts, temperate phages provide unique […]
Kavli Affiliate: Xiaoqing Qin Wang | Authors: Enhui Wu, Vijini Mallawaarachchi, Jinzhi Zhao, Yi Yang, Hebin Liu, Xiaoqing Wang, Chengpin Shen, Yu Lin and Liang Qiao | Summary: Microbiota are closely associated to human health and disease. Metaproteomics can provide a direct means to identify microbial proteins in microbiota for compositional and functional characterization. However, […]
Kavli Affiliate: Keri Martinowich | Authors: Henry L Hallock, Suhaas Adiraju, Jorge Miranda-Barrientos, Jessica M McInerney, Seyun Oh, Adrienne C DeBrosse, Ye Li, Gregory Carr and Keri Martinowich | Summary: Sustained attention, the ability to focus on an activity or stimulus over time, is significantly impaired in many psychiatric disorders, and there remains a major […]
Kavli Affiliate: Keri Martinowich | Authors: Sang Ho Kwon, Sowmya Parthiban, Madhavi Tippani, Heena R Divecha, Nicholas J Eagles, Jashandeep S Lobana, Stephen R Williams, Michelle Mark, Rahul A Bharadwaj, Joel E Kleinman, Thomas M Hyde, Stephanie C Page, Stephanie C Hicks, Keri Martinowich, Kristen R Maynard and Leonardo Collado-Torres | Summary: Neuropathological lesions in […]
Kavli Affiliate: Martin Lindquist, Brian Caffo | Authors: Bonnie B. Smith, Yi Zhao, Martin A. Lindquist and Brian Caffo | Summary: Brain functional connectivity analysis of resting-state functional magnetic resonance imaging (fMRI) data is typically performed in a standardized template space assuming consistency of connections across subjects. This can come in the form of one-edge-at-a-time […]
Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]