Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts

Posted by klaurent Columbia

Kavli Affiliate: Franck Polleux | Authors: Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J. Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, Makoto Nakakido, Kouhei Tsumoto, Yusuke Kishi, Yukiko Gotoh, Chulhwan Kwak, Hyun-Woo Rhee, Jeong Kon Seo, Hidetaka Kosako, Clint Potter, Bridget Carragher, Jennifer Lippincott-Schwartz, Franck Polleux and Yusuke Hirabayashi […]


Continue.. Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts

Alignment of spatial transcriptomics data using diffeomorphic metric mapping

Posted by klaurent Hopkins

Kavli Affiliate: Justus M Kebschull, Michael Miller, Jean Fan | Authors: Kalen Clifton, Manjari Anant, Gohta Aihara, Lyla Atta, Osagie K Aimiuwu, Justus M Kebschull, Michael I Miller, Daniel Tward and Jean Fan | Summary: Spatial transcriptomics (ST) technologies enable high throughput gene expression characterization within thin tissue sections. However, comparing spatial observations across sections, […]


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Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Elleke Tissink, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Guy Hindley, Daniel Roelfs, Oleksandr Frei, Chun Chieh Fan, Mats Nagel, Terje Naerland, Magdalena Budisteanu, Srdjan Djurovic, Lars T. Westlye, Martijn van den Heuvel, Danielle Posthuma, Tobias Kaufmann, Anders M. Dale and Ole Andreassen | Summary: Genetic pleiotropy […]


Continue.. Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Temperate gut phages are prevalent, diverse, and predominantly inactive

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Sofia Dahlman, Laura Avellaneda-Franco, Ciaren Kett, Dinesh Subedi, Remy B Young, Jodee A. Gould, Emily L Rutten, Emily L Gilliver, Christopher JR Turkington, Neda Nezam-Abadi, Juris A Grasis, Dena Lyras, Professor, Robert A Edwards, Samuel C Forster and Jeremy J Barr | Summary: Large-scale metagenomic and data mining efforts […]


Continue.. Temperate gut phages are prevalent, diverse, and predominantly inactive

Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

Posted by klaurent UCSF

Kavli Affiliate: Yifan Cheng | Authors: Armin Adly, Maxine Bi, Christopher Carlson, Abdullah Muhammad Syed, Alison Ciling, Jennifer Doudna, Yifan Cheng and David O. Morgan | Summary: The Nucleocapsid (N) protein of SARS-CoV-2 compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within virions. Assembly of vRNPs is inhibited by phosphorylation of the N protein […]


Continue.. Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

Estimating the Total Variance Explained by Whole-Brain Imaging for Zero-inflated Outcomes

Posted by klaurent UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Junting Ren, Robert John Loughnan, Bohan Xu, Wesley K. Thompson and Chun Chieh Fan | Summary: Zero-inflated outcomes are very common in behavioral data, particularly for responses to psychological questionnaires. Modeling these challenging distributions is further exacerbated by the absence of established statistical models capable of characterizing total signals […]


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Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Posted by klaurent UCSD / Salk

Kavli Affiliate: Ethan Bier | Authors: Leonardo Lima, Mateus Berni, Jamile Mota, Daniel Bressan, Alison Julio, Robson Cavalcante, Vanessa Macias, Zhiqian Li, Jason L. Rasgon, Ethan Bier and Helena Marcolla Araujo | Summary: Rhodnius prolixus is currently the model vector of choice for studying Chagas disease transmission, a debilitating disease caused by Trypanosoma cruzi parasites. […]


Continue.. Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids

Posted by klaurent Yale

Kavli Affiliate: Flora Vaccarino | Authors: Davide Capauto, Yifan Wang, Feinan Wu, Scott Norton, Jessica Mariani, Fumitaka Inoue, Gregory E. Crawford, The PsychENCODE Consortium, Nadav Ahituv, Alexej Abyzov and Flora M. Vaccarino | Summary: bstract Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human […]


Continue.. Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids

Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang, Karunesh Ganguly | Authors: NIKHILESH NATRAJ, Sarah Seko, Reza Abiri, Hongyi Yan, Yasmin Graham, Adelyn Tu-Chan, Edward F Chang and Karunesh Ganguly | Summary: The nervous system needs to balance the stability of neural representations with plasticity. It is unclear what is the representational stability of simple actions, particularly those that […]


Continue.. Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control

DARTsort: A modular drift tracking spike sorter for high-density multi-electrode probes

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: Julien Boussard, Charlie Windolf, Cole Hurwitz, Hyun Dong Lee, Han Yu, Olivier Winter and Liam Paninski | Summary: With the advent of high-density, multi-electrode probes, there has been a renewed interest in developing robust and scalable algorithms for spike sorting. Current spike sorting approaches, however, struggle to deal with […]


Continue.. DARTsort: A modular drift tracking spike sorter for high-density multi-electrode probes