Kavli Affiliate: Denis Wirtz | Authors: Gretchen M Alicea, Marie E Portuallo, Payal Patel, Mitchell E Fane, Alexis Carey, David W. Speicher, Andrew Kossenkov, Vito W Rebecca III, Denis Wirtz and Ashani T Weeraratna | Summary: Aged melanoma patients (>65 years old) have more aggressive disease relative to young patients (5-fold levels of insulin-like growth […]
Kavli Affiliate: Jin Kang | Authors: Emily H. Adhikari, Pei Lu, Ye Jin Kang, Ann R. McDonald, Jessica E. Pruszynski, Timothy A Bates, Savannah K. McBride, Mila Trank-Greene, Fikadu G Tafesse and Lenette L. Lu | Summary: Immunization in pregnancy is a critical tool that can be leveraged to protect the infant with an immature […]
Kavli Affiliate: Edward Callaway | Authors: Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Angeline C. Rivkin, Will N. Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew I. Aldridge, Qiurui Zeng, J.L. Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Jordan […]
Kavli Affiliate: Michael W. Young | Authors: Michelle Frankot, Peyton M Mueller, Michael E Young and Cole Vonder Haar | Summary: Statistical errors in preclinical science are a barrier to reproducibility and translation. For instance, linear models (e.g., ANOVA, linear regression) may be misapplied to data that violate assumptions. In behavioral neuroscience and psychopharmacology, linear […]
Kavli Affiliate: Jeremy Willsey | Authors: Wojciech M Michno, Alyssa Puno, Li Li, Amanda Everitt, Kate McCluskey, Fikri Birey, Saw Htun, Dhriti Nagar, Yuqin Dai, Emily Gurwitz, Jeremy Willsey and Anca M Pasca | Summary: Extremely preterm born individuals at < 28 postconceptional weeks (PCW) are at high risk for encephalopathy of prematurity and life-long […]
Kavli Affiliate: Wesley Thompson, Anders Dale | Authors: Pravesh Parekh, Chun Chieh Fan, Oleksandr Frei, Clare E Palmer, Diana M. Smith, Carolina Makowski, John Iverson, Diliana Pecheva, Dominic Holland, Robert Loughnan, Pierre Nedelec, Wesley K Thompson, Donald J. Hagler, Jr., Ole A. Andreassen, Terry L Jernigan, Thomas Nichols and Anders M. Dale | Summary: The […]
Kavli Affiliate: Mark Churchland | Authors: Sean M. Perkins, John P. Cunningham, Qi Wang and Mark M. Churchland | Summary: Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen to reflect scientific beliefs while yielding tractable computations. We document how low tangling — a typical property of motor-cortex neural trajectories — yields unusual […]
Kavli Affiliate: Rafael Yuste | Authors: Justin Lines and Rafael Yuste | Summary: Neuronal ensembles, defined as groups of coactive neurons, dominate cortical activity and are causally related to perceptual states and behavior. Interestingly, ensembles occur spontaneously in the absence of sensory stimulation. To better understand the function of ensembles in spontaneous activity, we explored […]
Kavli Affiliate: Mark Ellisman | Authors: Sumin Kim, Sebastien Phan, Thomas R Shaw, Mark H Ellisman, Sarah L Veatch, Sami J Barmada, Samuel S Pappas and William T Dauer | Summary: Nuclear pore complexes (NPCs) regulate information transfer between the nucleus and cytoplasm. NPC defects are linked to several neurological diseases, but the processes governing […]
Kavli Affiliate: Jin Kang | Authors: Dapeng Xiong, Junfei Zhao, Yunguang Qiu, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Weiqiang Lu, Siqi Liang, Jin Joo Kang, Charis Eng, Joseph Loscalzo, Feixiong Cheng and Haiyuan Yu | Summary: Human genome sequencing studies have identified numerous loci associated with complex diseases. However, translating human genetic and genomic findings […]