Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Posted by klaurent Yale

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]


Continue.. Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Categorization dynamically alters representations in human visual cortex

Posted by klaurent UCSD / Salk

Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Everyday visual search tasks require objects to be categorized according to behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating all visible apples into the […]


Continue.. Categorization dynamically alters representations in human visual cortex

Phables: from fragmented assemblies to high-quality bacteriophage genomes

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Vijini Mallawaarachchi, Michael J. Roach, Przemyslaw Decewicz, Bhavya Papudeshi, Sarah K Giles, Susanna R Grigson, George Bouras, Ryan D Hesse, Laura K Inglis, Abbey LK Hutton, Elizabeth A Dinsdale and Robert A Edwards | Summary: Microbial communities influence both human health and different environments. Viruses infecting bacteria, known as […]


Continue.. Phables: from fragmented assemblies to high-quality bacteriophage genomes

Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Posted by klaurent UCSF

Kavli Affiliate: Peter Walter | Authors: Rochelle Coulson, Valentina Frattini, Caitlin Moyer, Jennifer Hodges, Peter Walter, Philippe Mourrain, Yi Zuo and Gordon Wang | Summary: Fragile X syndrome (FXS) is caused by the functional loss of Fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of many proteins involved in synaptic function […]


Continue.. Translational modulation by ISRIB alleviates synaptic and behavioral phenotypes in Fragile X syndrome

Endogenous Opioid Signaling Regulates Proliferation of Spinal Cord Ependymal Cells

Posted by klaurent UCSF

Kavli Affiliate: Xin Duan | Authors: Wendy W.S. Yue, Kouki K. Touhara, Kenichi Toma, Xin Duan and David Julius | Summary: After injury, mammalian spinal cords develop scars to seal off the damaged area and prevent further injury. However, excessive scarring can hinder neural regeneration and functional recovery (1, 2). These competing actions underscore the […]


Continue.. Endogenous Opioid Signaling Regulates Proliferation of Spinal Cord Ependymal Cells

Enhancer-driven regulatory network of forebrain human development provides insights into autism

Posted by klaurent Yale

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Jessica Mariani, Feinan Wu, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Jeremy Schreiner, Cindy Khanh Nguyen, Neal Nolan, Anna Szekely, James C. McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M. Vaccarino | Summary: Cell differentiation involves shifts in chromatin organization allowing transcription […]


Continue.. Enhancer-driven regulatory network of forebrain human development provides insights into autism

Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Posted by klaurent Rockefeller

Kavli Affiliate: Alipasha Vaziri, Jeffrey M. Friedman | Authors: Bowen Tan, Caleb J Browne, Tobias Nobauer, Alipasha Vaziri, Jeffrey M. Friedman and Eric J. Nestler | Summary: Addiction prioritizes drug use over innate needs by hijacking brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron […]


Continue.. Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need

Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Jamil Mahmud, Brittany W Geiler, Juthi Biswas, Michael J Miller, Julia E Myers, Stephen M Matthews, Amanda B Wass, Christine M O’Connor and Gary C Chan | Summary: Establishing a non-productive quiescent/silent infection within monocytes is essential for spread of human cytomegalovirus (HCMV). Yet, how HCMV establishes a quiescent […]


Continue.. Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes

Reward expectation selectively boosts the firing of accumbens D1+ neurons during motivated approach

Posted by klaurent UCSF

Kavli Affiliate: Joshua Berke | Authors: Thomas Faust, Ali Mohebi and Joshua D Berke | Summary: The nucleus accumbens (NAc) helps govern motivation to pursue rewards. Two distinct sets of NAc projection neurons – expressing dopamine D1 versus D2 receptors – are thought to promote and suppress motivated behaviors respectively. However, support for this conceptual […]


Continue.. Reward expectation selectively boosts the firing of accumbens D1+ neurons during motivated approach

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Posted by klaurent Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich and Stephanie C Hicks | Summary: Norepinephrine (NE) neurons in the locus […]


Continue.. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics