Kavli Affiliate: Michael Shadlen, Liam Paninski, Mark Churchland, & Edward Chang | Authors: Charlie Windolf, Han Yu, Angelique C. Paulk, Domokos Meszéna, William Muñoz, Julien Boussard, Richard Hardstone, Irene Caprara, Mohsen Jamali, Yoav Kfir, Duo Xu, Jason E. Chung, Kristin K. Sellers, Zhiwen Ye, Jordan Shaker, Anna Lebedeva, Manu Raghavan, Eric Trautmann, Maxwell D. Melin, […]
Kavli Affiliate: Jin Kang | Authors: Brian J Bender, Julie E Pickett, Joao Braz, Hye Jin Kang, Stefan Gahbauer, Karnika Bhardwaj, Sian Rodriguez-Rosado, Yongfeng Liu, Manish Jain, Allan Basbaum, Bryan L Roth and Brian K. Shoichet | Summary: While opioid drugs remain among the most effective analgesics for pain management, adverse effects limit their use. […]
Kavli Affiliate: Alex Kolodkin | Authors: Noelle Thielman, Vanessa Funes, Sanjana Davuluri, Hector lbanez, Wei-Chih Sun, Juan Fu, Keyu Li, Stephen Muth, Xingyi Pan, Kenji Fujiwara, Dwayne Thomas, MacKenzie Henderson, Selina Shiqing Teh, Qingfeng Zhu, Elizabeth Thompson, Elizabeth M Jaffee, Alex Kolodkin, Fengxi Meng and Lei Zheng | Summary: Axon guidance molecules were found to […]
Kavli Affiliate: Eric D. Siggia | Authors: Archishman Raju and Eric Siggia | Summary: The lineage decision that generates the epiblast and primitive endoderm from the inner cell mass (ICM) is a paradigm for cell fate specification. Recent mathematics has formalized Waddington’s landscape metaphor and proven that lineage decisions in detailed gene network models must […]
Kavli Affiliate: Stefano Fusi & Mazen Kheirbek | Authors: Frances Xia, Valeria Fascianelli, Nina Vishwakarma, Frances Grace Ghinger, Stefano Fusi and Mazen Kheirbek | Summary: The neural dynamics that underlie divergent anhedonic responses to stress remain unclear. Here, we identified neuronal dynamics in an amygdala-hippocampal circuit that distinguish stress resilience and susceptibility. In a reward-choice […]
Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]
Kavli Affiliate: Shai Shaham | Authors: Nikolaos Stefanakis, Jessica Jiang, Yupu Liang and Shai Shaham | Summary: While most CNS glia arise from neuroectodermal progenitors, some, like microglia, are mesodermally derived. To understand mesodermal glia development and function, we investigated C. elegans GLR glia, which ensheath the brain neuropil and separate it from the circulatory-system […]
Kavli Affiliate: Michael Miller | Authors: David A. Alvarado, Luis Alberto Ibarra-Sanchez, Annemarie R. Mysonhimer, Tauseef A Khan, Rong Cao, Michael J. Miller and Hannah Holscher | Summary: Background Bifidobacterium animalis ssp. lactis DN-173 010/CNCM I-2494 (B. animalis) is a probiotic strain commonly added to yogurt. Yogurt and honey are a popular culinary pairing. Honey […]
Kavli Affiliate: Vikaas Sohal | Authors: Nicholas A Frost, Kevin C Donohue and Vikaas Sohal | Summary: The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information across different environments? Are contextual and socioemotional representations segregated or intermixed, […]
Kavli Affiliate: A. James Hudspeth | Authors: Camila M. Villasante, Xinyue Deng, Joel E. Cohen and A.J. Hudspeth | Summary: Mechanical force controls the opening and closing of mechanosensitive ion channels atop the hair bundles of the inner ear. The filamentous tip link connecting transduction channels to the tallest neighboring stereocilium modulates the force transmitted […]