Is the hydrogen of the 2’-hydroxyl group of HENMT1 a Schrödinger’s hydrogen?

Kavli Affiliate: Li Zhao | Authors: Philipp Kaldis and Li Na Zhao | Summary: piRNAs are important in protecting germline integrity. 3’-terminal 2’-O-methylation is essential for piRNA maturation and to protect it from degradation. HENMT1 carries out the 2’-O-methylation, which is of key importance for piRNA stability and functionality. However, neither the structure nor the […]


Continue.. Is the hydrogen of the 2’-hydroxyl group of HENMT1 a Schrödinger’s hydrogen?

Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion

Kavli Affiliate: Michael W. Young | Authors: Yi Sun, Tyler J. Florio, Sagar Gupta, Michael C. Young, Quinlen F. Marshall, Samuel E. Garfinkle, Georgia F. Papadaki, Hau V. Truong, Emily Mycek, Peiyao Li, Alvin Farrel, Nicole L. Church, Shereen Jabar, Matthew D. Beasley, Ben R. Kiefel, Mark Yarmarkovich, Leena Mallik, John M. Maris and Nikolaos […]


Continue.. Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion

EEG resting state alpha dynamics predict individual proneness to auditory hallucinations

Kavli Affiliate: David Linden | Authors: Hanna Honcamp, Suvarnalata Xanthate Duggirala, Julio Rodino Climent, Aland Astudillo, Nelson J. Trujillo-Barreto, Michael Schwartze, David E.J. Linden, Therese Amelsvoort, Wael El-Deredy and Sonja A Kotz | Summary: Introduction Auditory verbal hallucinations (AVH) are a transdiagnostic phenomenon but also occur in the general population. The disposition to experience AVH […]


Continue.. EEG resting state alpha dynamics predict individual proneness to auditory hallucinations

Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

Kavli Affiliate: Robert Edwards | Authors: Swayam Fnu Prakash, Nisha R Dhanushkodi, Latifa Zayou, Izabela Coimbra Ibraim, Afshana Quadiri, Pierre Gregoire Coulon, Delia F Tifrea, Berfin Suzler, Mohamed Amin, Amruth Chilukuri, Robert A Edwards, Hawa Vahed, Anthony B. Nesburn, Baruch D Kuppermann, Jeffrey B Ulmer, Dan Gil, Trevor M Jones and Lbachir BenMohamed | Summary: […]


Continue.. Cross-Protection Induced by Highly Conserved Human B, CD4+, and CD8+ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Kavli Affiliate: Jin Kang | Authors: Anca Mihalas, Sonali Arora, Samantha O’Connor, Heather Feldman, Christine E. Cucinotta, Kelly Mitchell, John Bassett, Dayoung Kim, Kang Jin, Pia Hoellerbauer, Jennifer Delegard, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Toshio Tsukiyama, Bruce J Aronow, Christopher J Plaisier, Anoop Patel and PATRICK PADDISON | Summary: In […]


Continue.. KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

Kavli Affiliate: Robert Edwards | Authors: David Martinez, Alexandra R. Schaefer, Tyler Gavitt, Michael Mallory, Esther Lee, Nicholas Catanzaro, Haiyan Chen, Kendra Gully, Trevor D. Scobey, Pooja Korategere, Alecia Brown, Lena Smith, Robert Parks, Maggie Barr, Amanda Newman, Cindy Bowman, John M. Powers, Katayoun Mansouri, Robert J Edwards, Ralph S. Baric, Barton Haynes and Kevin […]


Continue.. Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

Molecular recording of calcium signaling via calcium-dependent protein proximity labeling

Kavli Affiliate: Yuh Nung Jan | Authors: Jungwoo Wren Kim, Adeline J. H. Yong, Erin E. Aisenberg, Ted M. Dawson, Valina L. Dawson, Yuh-Nung Jan, Nicholas T. Ingolia, Wei Wang, Ruixuan Gao and Helen S. Bateup | Summary: Calcium ions serve as key intracellular signals. Local, transient increases in calcium concentrations can activate calcium sensor […]


Continue.. Molecular recording of calcium signaling via calcium-dependent protein proximity labeling

Stem cells tightly regulate dead cell clearance to maintain tissue fitness

Kavli Affiliate: Elaine Fuchs | Authors: Katherine S Stewart, Kevin AU Gonzales, Shaopeng Yuan, Matthew T Tierney, Alain R Bonny, Yihao Yang, Nicole R Infarinato, Christopher J Cowley, John M Levorse, H Amalia Pasolli, Sourav Ghosh, Carla V Rothlin and Elaine Fuchs | Summary: Macrophages and dendritic cells have long been appreciated for their ability […]


Continue.. Stem cells tightly regulate dead cell clearance to maintain tissue fitness

The Heritability of Human Connectomes: a Causal Modeling Analysis

Kavli Affiliate: Joshua Vogelstein | Authors: Jaewon Chung, Eric W Bridgeford, Michael Powell, Derek Pisner and Joshua T Vogelstein | Summary: The heritability of human connectomes is crucial for understanding the influence of genetic and environmental factors on variability in connectomes, and their implications for behavior and disease. However, current methods for studying heritability assume […]


Continue.. The Heritability of Human Connectomes: a Causal Modeling Analysis

A cross-species proteomic map of synapse development reveals neoteny during human postsynaptic density maturation

Kavli Affiliate: Arturo Alvarez-Buylla, Nenad Sestan, Alex Pollen, Arnold Kriegstein | Authors: Li Wang, Kaifang Pang, Li Zhou, Arantxa Cebrian-Silla, Susana Gonzalez-Granero, Shaohui Wang, Qiuli Bi, Matthew L. White, Brandon Ho, Jiani Li, Tao Li, Yonatan Perez, Eric J. Huang, Ethan A Winkler, Mercedes F Paredes, Rothem Kovner, Nenad Sestan, Alex A. Pollen, Pengyuan Liu, […]


Continue.. A cross-species proteomic map of synapse development reveals neoteny during human postsynaptic density maturation