Single neuron analysis of aging associated changes in learning reveals progressive impairments in transcriptional plasticity

Posted by klaurent Columbia

Kavli Affiliate: Robert Hawkins | Authors: Kerriann K Badal, Abhishek Sadhu, Carrie McCracken, Bindu L Raveendra, Sebastian Lozano-Villada, Amol C Shetty, Phillip Gillette, Yibo Zhao, Dustin Stommes, Lynne A Fieber, Michael C Schmale, Anup Mahurkar, Robert D Hawkins and Sathyanarayanan V Puthanveettil | Summary: Molecular mechanisms underlying aging associated impairments in learning and long-term memory […]


Continue.. Single neuron analysis of aging associated changes in learning reveals progressive impairments in transcriptional plasticity

Nucleus-Independent Transgenerational Small RNA Inheritance in C. elegans

Posted by klaurent Rockefeller

Kavli Affiliate: Shai Shaham | Authors: Itai Rieger, Guy Weintraub, Itamar Lev, Kesem Goldstein, Dana Bar-Zvi, Sarit Anava, Hila Gingold, Shai Shaham and Oded Rechavi | Summary: Studies using C. elegans nematodes demonstrated that, against the dogma, animals can transmit epigenetic information transgenerationally. While it is now clear that in these worms ancestral RNA interference […]


Continue.. Nucleus-Independent Transgenerational Small RNA Inheritance in C. elegans

Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

Posted by klaurent Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Joelle M Dorskind, Sriram Sudarsanam, Randal A Hand, Jakub Ziak, Maame Amoah-Dankwah, Luis Guzman-Clavel, John Lee Soto-Vargas and Alex L Kolodkin | Summary: Proper cortical lamination is essential for cognition, learning, and memory. Within the somatosensory cortex, pyramidal excitatory neurons elaborate axon collateral branches in a laminar-specific manner that […]


Continue.. Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons

Measuring stimulus-related redundant and synergistic functional connectivity with single cell resolution in auditory cortex

Posted by klaurent Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Loren Koçillari, Marco Celotto, Nikolas A. Francis, Shoutik Mukherjee, Behtash Babadi, Patrick O. Kanold and Stefano Panzeri | Summary: Measures of functional connectivity have played a central role in advancing our understanding of how information is communicated within the brain. Traditionally, these studies have focused on identifying redundant functional […]


Continue.. Measuring stimulus-related redundant and synergistic functional connectivity with single cell resolution in auditory cortex

Stimulus-specific enhancement of responses in mouse primary visual cortex mediated by GABA release from VIP cells

Posted by klaurent UCSF

Kavli Affiliate: Michael Stryker | Authors: Megumi Kaneko, Mahmood S Hoseini, James A Waschek and Michael P Stryker | Summary: When adult mice are repeatedly exposed to a particular visual stimulus for as little as one hour per day for several days while their visual cortex (V1) is in the high-gain state produced by locomotion, […]


Continue.. Stimulus-specific enhancement of responses in mouse primary visual cortex mediated by GABA release from VIP cells

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Posted by klaurent UCSF

Kavli Affiliate: Yifan Cheng | Authors: Un Seng Chio, Eugene Palovcak, Anton A. A. Autzen, Henriette E. Autzen, Elise N. Munoz, Zanlin Yu, Feng Wang, David A. Agard, Jean-Paul Armache, Geeta Narlikar and Yifan Cheng | Summary: Single-particle cryo-EM is widely used to determine enzyme-nucleosome complex structures. However, cryo-EM sample preparation remains challenging and inconsistent […]


Continue.. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

Posted by klaurent Yale

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Cells maintain optimal levels of lysosome degradative activity to protect against pathogens, clear waste and generate nutrients. Here we show that LRRK2, a protein that is tightly linked to Parkinson’s disease, negatively regulates lysosome degradative activity in macrophages and microglia via […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia Through MiT-TFE Transcription Factor Inhibition

Reports of the death of brain-behavior associations have been greatly exaggerated

Posted by klaurent UCSD / Salk

Kavli Affiliate: Timothy Brown, Anders Dale | Authors: Carolina Makowski, Timothy T Brown, Weiqi Zhao, Donald J Hagler, Pravesh Parekh, Hugh Garavan, Thomas E Nichols, Terry L Jernigan and Anders M Dale | Summary: Magnetic resonance imaging (MRI) has been a popular and useful non-invasive method to map patterns of brain structure and function to […]


Continue.. Reports of the death of brain-behavior associations have been greatly exaggerated

Spatially clustered neurons encode vocalization categories in the bat midbrain

Posted by klaurent Hopkins

Kavli Affiliate: Kishore V. Kuchibhotla, Cynthia F. Moss | Authors: Jennifer Lawlor, Melville Wohlgemuth, Cynthia F Moss and Kishore V Kuchibhotla | Summary: Rapid categorization of vocalizations enables adaptive behavior across species. While categorical perception is thought to arise in the neocortex, humans and other animals could benefit from functional organization of ethologically-relevant sounds at […]


Continue.. Spatially clustered neurons encode vocalization categories in the bat midbrain

Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Michael J. Lynch, Maithili Deshpande, Kurni Kyrniyati, Kai Zhang, Milinda James, Michael Miller, Sheng Zhang, Felipe J. Passalia, Elsio A. Wunder, Jr., Nyles W. Charon, Chunhao Li and Brian R Crane | Summary: Spirochete bacteria cause Lyme disease, leptospirosis, syphilis and several other human illnesses. Unlike other bacteria, spirochete […]


Continue.. Lysinoalanine crosslinking is a conserved post-translational modification in the spirochete flagellar hook