Kavli Affiliate: Li Zhao | Authors: Philipp Kaldis and Li Na Zhao | Summary: piRNAs are important in protecting germline integrity. 3’-terminal 2’-O-methylation is essential for piRNA maturation and to protect it from degradation. HENMT1 carries out the 2’-O-methylation, which is of key importance for piRNA stability and functionality. However, neither the structure nor the […]
Continue.. Is the hydrogen of the 2’-hydroxyl group of HENMT1 a Schrödinger’s hydrogen?