The 3-Dimensional Genome Drives the Evolution of Asymmetric Gene Duplicates via Enhancer Capture-Divergence

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: UnJin Lee, Deanna Arsala, Shengqian Xia, Cong Li, Mujahid Ali, Nicolas Svetec, Christopher Langer, Debora Sobreira, Ittai Eres, Dylan Sosa, Jianhai Chen, Li Zhang, Patrick Reilly, Alexander Guzzetta, J.J. Emerson, Peter Andolfatto, Li Zhao and Manyuan Long | Summary: Previous evolutionary models of duplicate gene evolution have overlooked the […]


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Dynamic categorization rules alter representations in human visual cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Abstract Everyday perceptual tasks require sensory stimuli to be dynamically encoded and analyzed according to changing behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating […]


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Comment on ‘Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation’

Posted by dbos UCSF

Kavli Affiliate: Joshua Berke | Authors: James Taniguchi, Riccardo Melani, Lynne Chantranupong, Michelle J Wen, Ali Mohebi, Joshua D Berke, Bernardo L Sabatini and Nicolas X Tritsch | Summary: Acetylcholine is widely believed to modulate the release of dopamine in the striatum of mammals. Experiments in brain slices clearly show that synchronous activation of striatal […]


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Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors:August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle J Travaglini, Mariano Gabitto, Rebecca D Hodge, Eitan Kaplan, Ed Lein, Phillip De Jager, David A Bennett, Eunjung Alice […]


Continue.. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Long range projections of oxytocin neurons in the marmoset brain

Posted by dbos UCSD / Salk

Kavli Affiliate: Cory Miller | Arthur Lefevre, Jazlynn Meza and Cory Miller | Summary: The neurohormone oxytocin (OT) has become a major target for the development of novel therapeutic strategies to treat psychiatric disorders such as autism spectrum disorder because of its integral role in governing many facets of mammalian social behavior. Whereas extensive work […]


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Basolateral amygdala population coding of a cued reward seeking state depends on orbitofrontal cortex

Posted by dbos Hopkins

Kavli Affiliate: Patricia Janak | David J Ottenheimer, Katherine R Vitale, Frederic Ambroggi, Patricia H Janak and Benjamin T Saunders | Summary: Basolateral amygdala (BLA) neuronal responses to conditioned stimuli are closely linked to the expression of conditioned behavior. An area of increasing interest is how the dynamics of BLA neurons relate to evolving behavior. […]


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Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers using chemistry

Posted by dbos UCSD / Salk

Kavli Affiliate: Timothy Brown | Pratik Kumar, Alina Gutu, Amelia Waring, Timothy A Brown, Luke D Lavis and Alison G. Tebo | Summary: Chemigenetic tags are versatile labels for fluorescence microscopy that combine some of the advantages of genetically encoded tags with small molecule fluorophores. The Fluorescence Activating and absorbance Shifting Tags (FASTs) bind a […]


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Pronounced early differentiation underlies zebra finch gonadal germ cell development

Posted by dbos Rockefeller

Kavli Affiliate: Erich Jarvis | First 5 Authors: Matthew T Biegler, Kirubel Belay, Wei Wang, Christina Szi, Paul G Collier, Ji-Dung Luo, Bettina Haase, Gregory L. Gedman, Asha V. Sidhu, Elijah Harter, Carlos Rivera-Lopez, Kwame Amoako-Boadu, Olivier Fedrigo, Hagen U. Tilgner, Thomas T Carroll, Erich D. Jarvis and Anna L. Keyte | Summary: The diversity […]


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Ketamine modulates a norepinephrine-astroglial circuit to persistently suppress futility-induced passivity

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | First 5 Authors: Marc Duque, Alex B. Chen, Eric Hsu, Sujatha Narayan, Altyn Rymbek, Shahinoor Begum, Gesine Saher, Adam Ezra Cohen, David E. Olson, David A Prober, Dwight E Bergles, Mark C Fishman, Florian Engert and Misha B Ahrens | Summary: Mood-altering compounds hold promise for the treatment of many […]


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Effects of parental age and polymer composition on short tandem repeat de novo mutation rates

Posted by dbos Columbia

Kavli Affiliate: Michael Goldberg | Authors: Michael E Goldberg, Michelle D Noyes, Evan E Eichler, Aaron Quinlan and Kelley Harris | Summary: Short tandem repeats (STRs) are hotspots of genomic variability in the human germline because of their high mutation rates, which have long been attributed largely to polymerase slippage during DNA replication. This model […]


Continue.. Effects of parental age and polymer composition on short tandem repeat de novo mutation rates