Removing direct photocurrent artifacts in optogenetic connectivity mapping data via constrained matrix factorization

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: Benjamin Antin, Masato Sadahiro, Marta Gajowa, Marcus A. Triplett, Hillel Adesnik and Liam Paninski | Summary: Monosynaptic connectivity mapping is crucial for building circuit-level models of neural computation. Two-photon optogenetic stimulation, when combined with whole-cell recordings, has the potential to map monosynaptic connectivity at an unprecedented scale. However, optogenetic […]


Continue.. Removing direct photocurrent artifacts in optogenetic connectivity mapping data via constrained matrix factorization

Hue selectivity from recurrent circuitry in Drosophila

Posted by klaurent Columbia

Kavli Affiliate: Rudy Behnia | Authors: Matthias P Christenson, Alvaro Sanz Diez, Sarah L Heath, Maia Saavedra-Weisenhaus, Atsuko Adashi, LF Abbott and Rudy Behnia | Summary: A universal principle of sensory perception is the progressive transformation of sensory information from broad non-specific signals to stimulus-selective signals that form the basis of perception. To perceive color, […]


Continue.. Hue selectivity from recurrent circuitry in Drosophila

Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

Posted by klaurent UCSD / Salk

Kavli Affiliate: Andrea Hasenstaub | Authors: David A. McCormick, Yousheng Shu and Andrea R Hasenstaub | Summary: The ventral pallidum (VP) contains GABA and glutamate (Glut) neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the cell-type-specific mechanisms by which VP projections to VTA drive […]


Continue.. Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

The h-current controls cortical recurrent network activity through modulation of dendrosomatic communication

Posted by klaurent UCSF

Kavli Affiliate: Andrea Hasenstaub | Authors: David A. McCormick, Yousheng Shu and Andrea R Hasenstaub | Summary: A fundamental feature of the cerebral cortex is the ability to rapidly turn on and off maintained activity within ensembles of neurons through recurrent excitation balanced by inhibition. Here we demonstrate that reduction of the h-current, which is […]


Continue.. The h-current controls cortical recurrent network activity through modulation of dendrosomatic communication

Resolving Non-identifiability Mitigates Bias in Models of Neural Tuning and Functional Coupling

Posted by klaurent UCSF

Kavli Affiliate: Kristofer Bouchard, Loren Frank, Christoph Kirst | Authors: Pratik Sachdeva, Ji Hyun Bak, Jesse A Livezey, Loren Frank, Christoph Kirst, Sharmodeep Bhattacharyya and Kristofer Bouchard | Summary: In the brain, all neurons are driven by the activity of other neurons, some of which maybe simultaneously recorded, but most are not. As such, models […]


Continue.. Resolving Non-identifiability Mitigates Bias in Models of Neural Tuning and Functional Coupling

Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: Taylor Bertucci, Kathryn R Bowles, Steven Lotz, Le Qi, Katherine Stevens, Susan K Goderie, Susan Borden, Laura Oja, Keith Lane, Ryan Lotz, Hailey Lotz, Rebecca Chowdhury, Shona Joy, Brigitte L Arduini, David C Butler, Michael Miller, Heide Baron, Carl Alexander Sandhof, M. Catarina Silva, Stephen J Haggarty, Celeste M […]


Continue.. Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations

Neural mechanisms to incorporate visual counterevidence in self motion estimation

Posted by klaurent Yale

Kavli Affiliate: Damon Clark | Authors: Ryosuke Tanaka, Baohua Zhou, Margarida Agrochao, Bara A. Badwan, Braedyn Au, Natalia C. B. Matos and Damon A. Clark | Summary: In selecting appropriate behaviors, animals should weigh sensory evidence both for and against specific beliefs about the world. For instance, animals measure optic flow to estimate and control […]


Continue.. Neural mechanisms to incorporate visual counterevidence in self motion estimation

SOL3D: Soft-lithography on 3D vat polymerised moulds for fast, versatile, and accessible high-resolution fabrication of customised multiscale cell culture devices with complex designs

Posted by klaurent NTNU

Kavli Affiliate: Valentina Di Maria | Authors: Cathleen Hagemann, Matthew C. D. Bailey, Eugenia Carraro, Valentina Maria Lionello, Noreen Khokhar, Pacharaporn Suklai, Carmen Moreno-Gonzalez, Kelly O’Toole, George Konstantinou, Sudeep Joshi, Eleonora Giagnorio, Mads Bergholt, Albane Imbert, Francesco Saverio Tedesco and Andrea Serio | Summary: Cell culture devices, such as microwells and microfluidic chips, are designed […]


Continue.. SOL3D: Soft-lithography on 3D vat polymerised moulds for fast, versatile, and accessible high-resolution fabrication of customised multiscale cell culture devices with complex designs

Direct Entorhinal Control of CA1 Temporal Coding

Posted by klaurent NTNU

Kavli Affiliate: Clifford Kentros | Authors: Matteo Guardamagna, Oscar M.T. Chadney, Federico Stella, Qiangwei Zhang, Clifford Kentros and Francesco P. Battaglia | Summary: Local computations of CA1 neurons are shaped by two direct input streams, from CA3 and EC LIII. By specifically silencing the direct input from the entorhinal cortex, we found that single-cell temporal […]


Continue.. Direct Entorhinal Control of CA1 Temporal Coding

Revealing abrupt transitions from goal-directed to habitual behavior

Posted by klaurent Hopkins

Kavli Affiliate: Kishore V. Kuchibhotla, Adam S. Charles | Authors: Sharlen Moore, Zyan Wang, Ziyi Zhu, Ruolan Sun, Angel Lee, Adam Charles and Kishore V Kuchibhotla | Summary: A fundamental tenet of animal behavior is that decision-making involves multiple ‘controllers.’ Initially, behavior is goal-directed, driven by desired outcomes, shifting later to habitual control, where cues […]


Continue.. Revealing abrupt transitions from goal-directed to habitual behavior