Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Posted by klaurent UCSF

Kavli Affiliate: Michael Stryker | Authors: Wendy Xin, Megumi Kaneko, Richard H Roth, Albert Zhang, Sonia Nocera, Jun B Ding, Michael P Stryker and Jonah R Chan | Summary: BACKGROUND: Developmental myelination is a protracted process in the mammalian brain. One theory for why oligodendrocytes mature so slowly posits that myelination may stabilize neuronal circuits […]


Continue.. Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

Posted by klaurent Rockefeller

Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Lijuan Feng, Douglas Barrows, Liangwen Zhong, Kart Matlik, Elizabeth G. Porter, Annaelle M. Djomo, Iris Yau, Alexey A. Soshnev, Thomas S. Carroll, Duancheng Wen, Mary E. Hatten, Benjamin A. Garcia and C. David Allis | Summary: Chromatin is a crucial regulator of gene expression and […]


Continue.. Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Posted by klaurent Hopkins

Kavli Affiliate: Peter Searson | Authors: Yi Dong, Blake A Johns, Linhao Ruan, Maged Zeineldin, Albert Liu, Sumana Raychaudhuri, Ian Chiu, Jin Zhu, Barbara Smith, Nan Zhao, Peter Searson, Shigeki Watanabe, Mark Donowitz, Tatianna Chantelle Larman and Rong Li | Summary: Inflammation-associated fibroblasts (IAFs) are associated with the progression and drug resistance of chronic inflammatory […]


Continue.. Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling

Posted by klaurent Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Shira Weingarten-Gabbay, Matthew R Bauer, Alexandra C Stanton, Susan Klaeger, Eva K Verzani, Daniel Lopez, Karl R Clauser, Steven A Carr, Jennifer G Abelin, Charles M Rice and Pardis C Sabeti | Summary: Unveiling the complete proteome of viruses is crucial to our understanding of the viral life […]


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Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach

Posted by klaurent Rockefeller

Kavli Affiliate: Charles M. Rice | Authors: Kunihiro Uryu, Nadine Soplop, Timothy P Sheahan, Maria-Teresa Catanese, Chuong Huynh, John Pena, Nancy Boudreau, Irina Matei, Candia Kenific, Ayako Hashimoto, Ayuko Hoshino, Charles M Rice and David Lyden | Summary: Scanning electron microscopy (SEM) offers an unparalleled view of the membrane topography of mammalian cells by using […]


Continue.. Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach

Unsupervised pattern discovery in spatial gene expression atlas reveals mouse brain regions beyond established ontology

Posted by klaurent UCSF

Kavli Affiliate: Reza Abbasi Asl | Authors: Robert Cahill, Yu Wang, Alex Lee, Hongkui Zeng, Bin Yu, Bosiljka Tasic and Reza Abbasi-Asl | Summary: The growth of large-scale spatial gene expression data requires new computational tools to extract major trends in gene expression in their native spatial context. Here, we describe an unsupervised and interpretable […]


Continue.. Unsupervised pattern discovery in spatial gene expression atlas reveals mouse brain regions beyond established ontology

Mixed Multi-Level Visual, Reward, and Motor Signals in Dorsomedial Frontal Cortex Area F7 during Active Naturalistic Video Exploration

Posted by klaurent Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Farid Aboharb, Stephen Serene, Julia Sliwa and Winrich A Freiwald | Summary: In the primate brain the frontal lobes support complex functions, including social cognition. Understanding the functional organization of these regions requires an approach for rich functional characterization. Here we used a novel paradigm, the visual exploration of […]


Continue.. Mixed Multi-Level Visual, Reward, and Motor Signals in Dorsomedial Frontal Cortex Area F7 during Active Naturalistic Video Exploration

Ventral CA1 Population Codes for Anxiety

Posted by klaurent Columbia

Kavli Affiliate: Stefano Fusi | Authors: Sean Chih-Hsiung Lim, Stefano Fusi and Rene Hen | Summary: The ventral hippocampus is a critical node in the distributed brain network that controls anxiety. Using miniature microscopy and calcium imaging, we recorded ventral CA1 (vCA1) neurons in freely moving mice as they explored variants of classic behavioral assays […]


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Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional phenotypes in Down Syndrome

Posted by klaurent UCSD / Salk

Kavli Affiliate: Nicola Allen | Authors: Ashley N Brandebura, Quinn N Asbell, Mariel Kristine B Micael and Nicola J Allen | Summary: Neuronal dendrite structure and synapse formation is tightly regulated during development to promote proper connectivity. Astrocyte-secreted proteins act as guidance and pro-synaptogenic factors, and astrocyte protein secretion is dysregulated in neurodevelopmental disorders with […]


Continue.. Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional phenotypes in Down Syndrome

Using a function-first “scout fragment”-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller, Ekaterina V. Vinogradova | Authors: Jared R Ramsey, Patrick M M Shelton, Tyler K. Heiss, Paul Dominic B Olinares, Lauren E Vostal, Heather Soileau, Michael Grasso, Sara Warrington, Stephanie Adaniya, Michael Miller, Shan Sun, David J Huggins, Robert W Myers, Brian T Chait, Ekaterina V Vinogradova and Tarun M Kapoor | […]


Continue.. Using a function-first “scout fragment”-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes