Kavli Affiliate: Su Guo | Authors: Chee San Tong, Maohan Su, He Sun, Xiang Le Chua, Su Guo, Ravinraj S/O Ramaraj, Ann Gie Lee, Nicole Wen Pei Ong, Yansong Miao and Min Wu | Summary: The coordination between actin and microtubule network is crucial, yet our understanding of the underlying mechanisms remains limited. In this […]
Kavli Affiliate: Hey-Kyoung Lee | Authors: Sarah Kruessel, Ishana Deb, Seungkyu Son, Gabrielle Ewall, Minhyeok Chang, Hey-Kyoung Lee, Won Do Heo and Hyung-Bae Kwon | Summary: Dendritic spines are structural correlates of excitatory synapses maintaining stable synaptic communications. However, this strong spine-synapse relationship was mainly characterized in excitatory pyramidal neurons (PyNs), raising a possibility that […]
Kavli Affiliate: Dwight Bergles, Seth Blackshaw | Authors: Ingie Hong, Juhyun Kim, Thomas Hainmueller, Dong Won Kim, Richard C. Johnson, Soo Hyun Park, Nathachit Limjunyawong, Zhuonan Yang, David Cheon, Taeyoung Hwang, Amit Agarwal, Thibault Cholvin, Fenna M. Krienen, Steven A. McCarroll, Xinzhong Dong, David A. Leopold, Seth Blackshaw, Dwight E. Bergles, Marlene Bartos, Solange P. […]
Kavli Affiliate: Reza Shadmehr | Authors: Paul Hage, In Kyu Jang, Vivian Looi, Mohammad Amin Fakharian, Simon P Orozco, Ehsan Sedaghat-Nejad, Jay Pi and Reza Shadmehr | Summary: We prefer to decline effortful rewards, but if the circumstances require it, we will move only slowly to harvest them. Why should economic variables such as reward […]
Kavli Affiliate: Patricia Janak | Authors: Eric Garr, Yifeng Cheng, Huijeong Jeong, Sara Brooke, Laia Castell, Aneesh Bal, Robin Magnard, Vijay Mohan K. Namboodiri and Patricia H. Janak | Summary: Learning causal relationships relies on understanding how often one event precedes another. To gain an understanding of how dopamine neuron activity and neurotransmitter release change […]
Kavli Affiliate: Michael Higley, Alipasha Vaziri, Kristina Nielsen | Authors: Che-Hang Yu, Yiyi Yu, Liam M. Adsit, Jeremy T. Chang, Jad Barchini, Andrew H. Moberly, Hadas Benisty, Jinkyung Kim, Brent K Young, Kathleen Heng, Deano M. Farinella, Austin Leikvoll, Rishaab Pavan, Rachel Vistein, Brandon R. Nanfito, David G. C. Hildebrand, Santiago Otero-Coronel, Alipasha Vaziri, Jeffery […]
Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Santiago C Lopez, Matias Rojas-Montero, Chloe B Fishman and Seth L Shipman | Summary: Our understanding of genomics is limited by the scale of our genomic technologies. While libraries of genomic manipulations scaffolded on CRISPR gRNAs have been transformative, these existing approaches are typically multiplexed across genomes. […]
Kavli Affiliate: Seth Blackshaw | Authors: Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou and Jiang Qian | Summary: The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, […]
Kavli Affiliate: Liam Paninski | Authors: Benjamin Antin, Masato Sadahiro, Marta Gajowa, Marcus A. Triplett, Hillel Adesnik and Liam Paninski | Summary: Monosynaptic connectivity mapping is crucial for building circuit-level models of neural computation. Two-photon optogenetic stimulation, when combined with whole-cell recordings, has the potential to map monosynaptic connectivity at an unprecedented scale. However, optogenetic […]
Kavli Affiliate: Rudy Behnia | Authors: Matthias P Christenson, Alvaro Sanz Diez, Sarah L Heath, Maia Saavedra-Weisenhaus, Atsuko Adashi, LF Abbott and Rudy Behnia | Summary: A universal principle of sensory perception is the progressive transformation of sensory information from broad non-specific signals to stimulus-selective signals that form the basis of perception. To perceive color, […]