Structure and function of an intermediate GPCR-G protein complex

Kavli Affiliate: Yifan Cheng | Authors: Maxine Bi, Xudong Wang, Jinan Wang, JUN xu, Wenkai Sun, Victtor Ayo Adediwrua, Yinglong Miao, Yifan Cheng and Libin Ye | Summary: Despite hundreds of GPCR-Gαβγ complex structures, these snapshots uniquely capture the fully activated complex. Consequently, a comprehensive understanding of the conformational transitions during GPCR activation and the […]


Continue.. Structure and function of an intermediate GPCR-G protein complex

Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Kavli Affiliate: Pietro De Camilli | Authors: Hanieh Falahati, Yumei Wu and Pietro De Camill | Summary: Abstract The endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites, and the cisternal organelle of axonal initial segments. Both organelles […]


Continue.. Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

Kavli Affiliate: Dwight Bergles | Authors: Vered Kellner, Patrick Parker, Xuelong Mi, Guoqiang Yu, Gesine Saher and Dwight E Bergles | Summary: Abstract Afferent neurons in developing sensory organs exhibit a prolonged period of burst firing prior to the onset of sensory experience. This intrinsically generated activity propagates from the periphery through central processing centers […]


Continue.. Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

Neural correlates of individual facial recognition in a social wasp

Kavli Affiliate: Winrich Freiwald | Authors: Christopher M. Jernigan, Winrich A. Freiwald and Michael J. Sheehan | Summary: Abstract Individual recognition is critical for social behavior across species. Whether recognition is mediated by circuits specialized for social information processing has been a matter of debate. Here we examine the neurobiological underpinning of individual visual facial […]


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Cellular and Molecular Basis of Leptin Resistance

Kavli Affiliate: Jeffrey M. Friedman | Authors: Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Ji-Dung Luo, Joshua D. Rabinowitz and Jeffrey M. Friedman | Summary: Obese humans and diet induced obese mice (DIO) have high leptin levels and fail to respond to the exogenous hormone suggesting that obesity is caused by leptin resistance, the […]


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Sliding windows analysis can undo the effects of preprocessing when applied to fMRI data

Kavli Affiliate: Martin Lindquist | Authors: Martin Lindquist | Summary: Resting-state fMRI (rs-fMRI) data is used to study the intrinsic functional connectivity (FC) in the human brain. Recently, interest has focused on studying the temporal dynamics of FC on short timescales, ranging from seconds to minutes. These studies of time-varying FC (TVFC) have enabled the […]


Continue.. Sliding windows analysis can undo the effects of preprocessing when applied to fMRI data

The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Kavli Affiliate: Yishi Jin | Authors: Anjali Sandhu, Xiaohui Lyu, Xinghaoyun Wan, Xuefeng Meng, Ngang Heok Tang, Gilberto Gonzalez, Ishana N Syed, Lizhen Chen, Yishi Jin and Andrew D Chisholm | Summary: Microtubules (MTs) are dynamic components of the cytoskeleton and play essential roles in morphogenesis and maintenance of tissue and cell integrity. Despite recent […]


Continue.. The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Increased functional integration of emotional control network in late adulthood

Kavli Affiliate: Maryam Ziaei | Authors: Leona R Baetz, Shuer Ye, Xiaqing Lan and Maryam Ziaei | Summary: Across the adult lifespan, there are changes in how emotions are perceived and regulated. As individuals age, there is an observed improvement in emotion regulation and overall quicker recovery from negative emotions. While previous studies have shown […]


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Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake

Kavli Affiliate: Jeffrey M. Friedman | Authors: Han L. Tan, Luping Yin, Yuqi Tan, Jessica Ivanov, Kaja Plucinska, Anoj Ilanges, Brian R Herb, Putianqi Wang, Christin Kosse, Paul Cohen, Dayu Lin and Jeffrey M Friedman | Summary: Leptin is an adipose tissue hormone that maintains homeostatic control of adipose tissue mass by regulating the activity […]


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A Simple Subcortical Feeding Circuit Linking Interoceptive Inputs to Consummatory Behavior

Kavli Affiliate: Zachary Knight and Jeffrey M. Friedman | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: TThe brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the underlying circuitry linking inputs to outputs is unknown. Here we delineate a subcortical circuit in […]


Continue.. A Simple Subcortical Feeding Circuit Linking Interoceptive Inputs to Consummatory Behavior