Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

Kavli Affiliate: Timothy Brown, Anders Dale | Authors: Carolina Makowski, Timothy T Brown, Weiqi Zhao, Donald J Hagler, Pravesh Parekh, Hugh Garavan, Thomas E Nichols, Terry L Jernigan and Anders M Dale | Summary: Magnetic resonance imaging (MRI) is a popular and useful non-invasive method to map patterns of brain structure and function to complex […]


Continue.. Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Kavli Affiliate: Michael Stryker | Authors: Wendy Xin, Megumi Kaneko, Richard H Roth, Albert Zhang, Sonia Nocera, Jun B Ding, Michael P Stryker and Jonah R Chan | Summary: BACKGROUND: Developmental myelination is a protracted process in the mammalian brain. One theory for why oligodendrocytes mature so slowly posits that myelination may stabilize neuronal circuits […]


Continue.. Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

Kavli Affiliate: Mary E. Hatten, C. David Allis | Authors: Lijuan Feng, Douglas Barrows, Liangwen Zhong, Kart Matlik, Elizabeth G. Porter, Annaelle M. Djomo, Iris Yau, Alexey A. Soshnev, Thomas S. Carroll, Duancheng Wen, Mary E. Hatten, Benjamin A. Garcia and C. David Allis | Summary: Chromatin is a crucial regulator of gene expression and […]


Continue.. Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Kavli Affiliate: Peter Searson | Authors: Yi Dong, Blake A Johns, Linhao Ruan, Maged Zeineldin, Albert Liu, Sumana Raychaudhuri, Ian Chiu, Jin Zhu, Barbara Smith, Nan Zhao, Peter Searson, Shigeki Watanabe, Mark Donowitz, Tatianna Chantelle Larman and Rong Li | Summary: Inflammation-associated fibroblasts (IAFs) are associated with the progression and drug resistance of chronic inflammatory […]


Continue.. Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Pan-viral ORFs discovery using Massively Parallel Ribosome Profiling

Kavli Affiliate: Charles M. Rice | Authors: Shira Weingarten-Gabbay, Matthew R Bauer, Alexandra C Stanton, Susan Klaeger, Eva K Verzani, Daniel Lopez, Karl R Clauser, Steven A Carr, Jennifer G Abelin, Charles M Rice and Pardis C Sabeti | Summary: Unveiling the complete proteome of viruses is crucial to our understanding of the viral life […]


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Engineered bacteria launch and control an oncolytic virus

Kavli Affiliate: Charles M. Rice | Authors: Zakary S. Singer, Jonathan Pabon, Hsinyen Huang, Charles M. Rice and Tal Danino | Summary: The ability of bacteria and viruses to selectively replicate in tumors has led to synthetic engineering of new microbial therapies. Here we design a cooperative strategy whereby S. typhimurium bacteria transcribe and deliver […]


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Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach

Kavli Affiliate: Charles M. Rice | Authors: Kunihiro Uryu, Nadine Soplop, Timothy P Sheahan, Maria-Teresa Catanese, Chuong Huynh, John Pena, Nancy Boudreau, Irina Matei, Candia Kenific, Ayako Hashimoto, Ayuko Hoshino, Charles M Rice and David Lyden | Summary: Scanning electron microscopy (SEM) offers an unparalleled view of the membrane topography of mammalian cells by using […]


Continue.. Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach

Unsupervised pattern discovery in spatial gene expression atlas reveals mouse brain regions beyond established ontology

Kavli Affiliate: Reza Abbasi Asl | Authors: Robert Cahill, Yu Wang, Alex Lee, Hongkui Zeng, Bin Yu, Bosiljka Tasic and Reza Abbasi-Asl | Summary: The growth of large-scale spatial gene expression data requires new computational tools to extract major trends in gene expression in their native spatial context. Here, we describe an unsupervised and interpretable […]


Continue.. Unsupervised pattern discovery in spatial gene expression atlas reveals mouse brain regions beyond established ontology

Mixed Multi-Level Visual, Reward, and Motor Signals in Dorsomedial Frontal Cortex Area F7 during Active Naturalistic Video Exploration

Kavli Affiliate: Winrich Freiwald | Authors: Farid Aboharb, Stephen Serene, Julia Sliwa and Winrich A Freiwald | Summary: In the primate brain the frontal lobes support complex functions, including social cognition. Understanding the functional organization of these regions requires an approach for rich functional characterization. Here we used a novel paradigm, the visual exploration of […]


Continue.. Mixed Multi-Level Visual, Reward, and Motor Signals in Dorsomedial Frontal Cortex Area F7 during Active Naturalistic Video Exploration

Ventral CA1 Population Codes for Anxiety

Kavli Affiliate: Stefano Fusi | Authors: Sean Chih-Hsiung Lim, Stefano Fusi and Rene Hen | Summary: The ventral hippocampus is a critical node in the distributed brain network that controls anxiety. Using miniature microscopy and calcium imaging, we recorded ventral CA1 (vCA1) neurons in freely moving mice as they explored variants of classic behavioral assays […]


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