Kavli Affiliate: Daniel Minor | Authors: Parker E Deal, Haerim Lee, Abhisek Mondal, Marco Lolicato, Philipe Ribeiro Furtado de Mandonca, Holly Black, Xochina El-Hilali, Clifford Bryant, Ehud Y Isacoff, Adam Renslo and Daniel L Minor, Jr. | Summary: K2P potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune […]
Kavli Affiliate: Priya Rajasethupathy | Authors: Josue M Regalado, Ariadna Corredera Asensio, Theresa Haunold, Andrew C Toader, Yan Ran Li, Lauren A Neal and Priya Rajasethupathy | Summary: Learning requires the ability to link actions to outcomes. How motivation facilitates learning is not well understood. We designed a behavioral task in which mice self-initiate trials […]
Kavli Affiliate: A. James Hudspeth | Authors: Ryohei Oya, Kwang Min Woo, Brian Fabella, Rodrigo Gogui Alonso and Albert James Hudspeth | Summary: In the receptor organs of the inner ear and lateral line, sensory hair cells detect mechanical stimuli such as sounds, accelerations, and water movements. In each instance a stimulus deflects the hair […]
Kavli Affiliate: Winrich Freiwald | Authors: Ben Deen, Gasi Husain and Winrich A Freiwald | Summary: How does the brain process the faces of familiar people? Neuropsychological studies have argued for an area of the temporal pole (TP) linking faces with person identities, but magnetic susceptibility artifacts in this region have hampered its study with […]
Kavli Affiliate: Rudy Behnia | Authors: Ishani Ganguly, Emily L. Heckman, Ashok Litwin-Kumar, E. Josephine Clowney and Rudy Behnia | Summary: The arthropod mushroom body is well-studied as an expansion layer that represents olfactory stimuli and links them to contingent events. However, 8% of mushroom body Kenyon cells in Drosophila melanogaster receive predominantly visual input, […]
Kavli Affiliate: Richard Axel | Authors: Jennifer J Bussell, Ryan P Badman, Christian David Márton, Ethan S Bromberg-Martin, LF Abbott, Kanaka Rajan and Richard Axel | Summary: HAnimals are motivated to acquire knowledge of their world. They seek information that does not influence reward outcomes suggesting that information has intrinsic value. We have asked whether […]
Kavli Affiliate: Pietro De Camilli | Authors: Nisha Mohd Rafiq, Kenshiro Fujise, Martin Rosenfeld, Peng Xu, Yumei Wu and Pietro De Camilli | Summary: Synaptojanin-1 (SJ1) is a major neuronal-enriched PI(4,5)P2 4- and 5-phosphatase implicated in the shedding of endocytic factors during endocytosis. A mutation (R258Q) that impairs selectively its 4-phosphatase activity causes Parkinsonism in […]
Kavli Affiliate: Costa, Rui | Authors: Joseph Pemberton, Paul Chadderton and Rui Ponte Costa | Summary: Abstract To drive behavior, the cortex must bridge sensory cues with future outcomes. However, the principles by which cortical networks learn such sensory-behavioural transformations remain largely elusive. Here, we posit that the cerebellum assumes a crucial role in driving […]
Kavli Affiliate: Leslie B. Vosshall | Authors: Takeshi Morita, Nia G Lyn, Ricarda K von Heynitz, Olivia V Goldman, Trevor R Sorrells, Matthew DeGennaro, Benjamin J Matthews, Leah Houri-Zeevi and Leslie B Vosshall | Summary: Sensory compensation is a process that allows individuals with a loss of one sense, for instance hearing or vision, to […]
Kavli Affiliate: Zachary Knight & Jeffrey M. Friedman | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: The brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the underlying circuitry linking inputs to outputs is unknown. Here we delineate a subcortical circuit in […]