LET-381/FoxF and UNC-30/Pitx2 control the development of C. elegans mesodermal glia that regulate motor behavior.

Posted by dbos Rockefeller

Kavli Affiliate: Shai Shaham | Authors: Nikolaos Stefanakis, Jessica Jiang, Yupu Liang and Shai Shaham | Summary: While most CNS glia arise from neuroectodermal progenitors, some, like microglia, are mesodermally derived. To understand mesodermal glia development and function, we investigated C. elegans GLR glia, which ensheath the brain neuropil and separate it from the circulatory-system […]


Continue.. LET-381/FoxF and UNC-30/Pitx2 control the development of C. elegans mesodermal glia that regulate motor behavior.

Honey varietals differentially impact Bifidobacterium animalis ssp lactis survivability in yogurt through simulated in vitro digestion

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: David A. Alvarado, Luis Alberto Ibarra-Sanchez, Annemarie R. Mysonhimer, Tauseef A Khan, Rong Cao, Michael J. Miller and Hannah Holscher | Summary: Background Bifidobacterium animalis ssp. lactis DN-173 010/CNCM I-2494 (B. animalis) is a probiotic strain commonly added to yogurt. Yogurt and honey are a popular culinary pairing. Honey […]


Continue.. Honey varietals differentially impact Bifidobacterium animalis ssp lactis survivability in yogurt through simulated in vitro digestion

Context-invariant socioemotional encoding by prefrontal ensembles

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Nicholas A Frost, Kevin C Donohue and Vikaas Sohal | Summary: The prefrontal cortex plays a key role in social interactions, anxiety-related avoidance, and flexible context- dependent behaviors, raising the question: how do prefrontal neurons represent socioemotional information across different environments? Are contextual and socioemotional representations segregated or intermixed, […]


Continue.. Context-invariant socioemotional encoding by prefrontal ensembles

Nanomechanics of wild-type and mutant dimers of the tip-link protein protocadherin 15

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Camila M. Villasante, Xinyue Deng, Joel E. Cohen and A.J. Hudspeth | Summary: Mechanical force controls the opening and closing of mechanosensitive ion channels atop the hair bundles of the inner ear. The filamentous tip link connecting transduction channels to the tallest neighboring stereocilium modulates the force transmitted […]


Continue.. Nanomechanics of wild-type and mutant dimers of the tip-link protein protocadherin 15

Encoding of melody in the human auditory cortex

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Narayan Sankaran, Matthew K Leonard, Frederic E Theunissen and Edward F Chang | Summary: Melody is a core component of music in which discrete pitches are serially arranged to convey emotion and meaning. Perception of melody varies along several pitch-based dimensions: (1) the absolute pitch of notes, (2) the […]


Continue.. Encoding of melody in the human auditory cortex

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang | Authors: Sunada Khadka, Yu-Hsi Lin, Jeffrey J Ackroyd, Yi-An Chen, Yanghui Sheng, Wubin Qian, Sheng Guo, Yining Chen, Eliot Itzkow Behr, Yasaman Barekatin, Md. Nasir Uddin, Kenisha Arthur, Victoria C Yan, Edward Chang, Anton Poral, Theresa Tran, Wen-Hao Hsu, Surendra Chaurasiya, Dimitra K. Georgiou, John M. Asara, Floris P. Barthel, […]


Continue.. Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington’s Disease

Posted by klaurent Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Matthew R Paul, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in Huntington’s disease (HD) cortex, the nature of somatic […]


Continue.. Selective Vulnerability of Layer 5a Corticostriatal Neurons in Huntington’s Disease

Development of covalent chemogenetic K2P channel activators

Posted by dbos UCSF

Kavli Affiliate: Daniel Minor | Authors: Parker E Deal, Haerim Lee, Abhisek Mondal, Marco Lolicato, Philipe Ribeiro Furtado de Mandonca, Holly Black, Xochina El-Hilali, Clifford Bryant, Ehud Y Isacoff, Adam Renslo and Daniel L Minor, Jr. | Summary: K2P potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune […]


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Neural activity ramps in frontal cortex signal extended motivation during learning

Posted by dbos Rockefeller

Kavli Affiliate: Priya Rajasethupathy | Authors: Josue M Regalado, Ariadna Corredera Asensio, Theresa Haunold, Andrew C Toader, Yan Ran Li, Lauren A Neal and Priya Rajasethupathy | Summary: Learning requires the ability to link actions to outcomes. How motivation facilitates learning is not well understood. We designed a behavioral task in which mice self-initiate trials […]


Continue.. Neural activity ramps in frontal cortex signal extended motivation during learning

Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Ryohei Oya, Kwang Min Woo, Brian Fabella, Rodrigo Gogui Alonso and Albert James Hudspeth | Summary: In the receptor organs of the inner ear and lateral line, sensory hair cells detect mechanical stimuli such as sounds, accelerations, and water movements. In each instance a stimulus deflects the hair […]


Continue.. Influence of myosin regulatory light chain and myosin light chain kinase on hair cells of the inner ear