Kavli Affiliate: Adam S. Charles | Authors: Victor Geadah, G. Barello, Adam Charles and Jonathan Pillow | Summary: The sparse coding model posits that the visual system has evolved to efficiently code natural stimuli using a sparse set of features from an overcomplete dictionary. The original sparse coding model suffered from two key limitations, however: […]
Kavli Affiliate: Anna Molofsky and Jeanne Paz | Authors: Nathan A. Ewing-Crystal, Nicholas M. Mroz, Anthony A. Chang, Eric Dean Merrill, Sofia E. Caryotakis, Leon Teo, Amara Larpthaveesarp, Tatsuya Tsukui, Aditya Katewa, Remy Pennington, Gabriel L. McKinsey, Sophia Nelson, Agnieszka Ciesielska, Madelene W. Dahlgren, Helena Paidassi, Saket Jain, Manish K. Aghi, James A. Bourne, Jeanne […]
Kavli Affiliate: Damon Clark | Authors: Patricia Janak | Summary: Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously […]
Kavli Affiliate: Damon Clark | Authors: Tong Gou, Catherine A Matulis and Damon A Clark | Summary: Sensory systems adapt their response properties to the statistics of their inputs. For instance, visual systems adapt to low-order statistics like mean and variance to encode the stimulus efficiently or to facilitate specific downstream computations. However, it remains […]
Kavli Affiliate: Sreekanth Chalasani | Authors: Caroline S Muirhead, Kirthi C Reddy, Sophia Guerra, Michael Rieger, Michael P Hart, Jagan Srinivasan and Sreekanth H Chalasani | Summary: Neurexins and their canonical binding partners, neuroligins, are localized to neuronal pre-, and post-synapses, respectively, but less is known about their role in driving behaviors. Here, we use […]
Kavli Affiliate: Nicola Allen | Authors: Laura Sancho, Matthew M Boisvert, Trinity Dawoodtabar, Jillybeth Burgado, Ellen Wang and Nicola J Allen | Summary: Neural circuits in many brain regions are refined by experience. Sensory circuits support higher plasticity at younger ages during critical periods – times of circuit refinement and maturation – and limit plasticity […]
Kavli Affiliate: Xingde Li | Authors: Wenxuan Liang, Yuehan Liu, Honghua Guan, Vorada Sakulsaengprapha, Katherine Luby-Phelps, Mala Mahendroo and Xingde Li | Summary: Background Preterm birth (PTB) is a global public health issue affecting millions of newborns every year. Orchestrated remodeling of the cervix is essential for normal pregnancy and birth, while PTB is closely […]
Kavli Affiliate: Seth Blackshaw | Authors: Qiang Liu, Jiali Xiong, Dong Won Kim, Sang Soo Lee, Benjamin J. Bell, Chloe Alexandre, Seth Blackshaw, Alban Latremoliere and Mark N. Wu | Summary: Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN), in concert with local clocks throughout the body. While many brain regions exhibit […]
Kavli Affiliate: Richard Huganir | Authors: Thomas L Dunham, Julia R Wilkerson, Richard C Johnson, Richard L. Huganir and Lenora J Volk | Summary: WWC2 (WW and C2 domain-containing protein) is implicated in several neurological disorders, however its function in the brain has yet to be determined. Here, we demonstrate that WWC2 interacts with inhibitory […]
Kavli Affiliate: Hana El-Samad | Authors: Sarah S. Soliman, Devan H. Shah, Hana El-Samad and Zara Y. Weinberg | Summary: Synthetic developmental biology uses engineering approaches to understand multicellularity with goals ranging from recapitulating development to building synthetic organisms. Current approaches include engineering multicellular patterning, controlling differentiation, and implementing cooperative cellular behaviors in model systems. […]