AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform […]


Continue.. AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

A Novel Dual Probe-based Method for Mutation Detection using Isothermal Amplification

Posted by dbos Hopkins

Kavli Affiliate: Michael Miller | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Cost efficient and rapid detection tools to detect mutations especially those linked to drug-resistance are important to address concerns of the rising multi-drug resistance infections. Here we integrated dual probes, namely a calibrator probe and an indicator probe, […]


Continue.. A Novel Dual Probe-based Method for Mutation Detection using Isothermal Amplification

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Geonhui Lee, Claudia Wong, Anna Cho, Junior J. West, Ashleigh J. Crawford, Gabriella C. Russo, Bishwa Ranjan Si, Jungwoo Kim, Lauren Hoffner, Cholsoon Jang, Moonjung Jung, Robert D. Leone, Konstantinos Konstantopoulos, Andrew J. Ewald, Denis Wirtz and Sangmoo Jeong | Summary: The loss of E-cadherin (E-cad), an epithelial cell […]


Continue.. Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

Pulsatile electrical stimulation creates predictable, correctable disruptions in neural firing

Posted by dbos Hopkins

Kavli Affiliate: Kathleen Cullen | Authors: Cynthia R Steinhardt, Diana E Mitchell, Kathleen E Cullen and Gene Y Fridman | Summary: Electrical stimulation is a key tool in neuroscience, both in brain mapping studies and in many therapeutic applications such as cochlear, vestibular, and retinal neural implants. Due to safety considerations, stimulation is restricted to […]


Continue.. Pulsatile electrical stimulation creates predictable, correctable disruptions in neural firing

Parallel Encoding of Speech in Human Frontal and Temporal Lobes

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Patrick W Hullett, Matthew K Leonard, Maria Luisa W Gorno-Tempini, Maria Luisa Mandelli and Edward F Chang | Summary: Models of speech perception are centered around a hierarchy in which auditory representations in the thalamus propagate to primary auditory cortex, then to the lateral temporal cortex, and finally through […]


Continue.. Parallel Encoding of Speech in Human Frontal and Temporal Lobes

Continuous Bump Attractor Networks Require Explicit Error Coding for Gain Recalibration

Posted by klaurent Hopkins

Kavli Affiliate: James Knierim | Authors: Gorkem Secer, James J. Knierim and Noah J. Cowan | Summary: Representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how the brain maintains these representations is given by continuous bump attractor networks (CBANs) in a broad range of brain […]


Continue.. Continuous Bump Attractor Networks Require Explicit Error Coding for Gain Recalibration

Metric Ion Classification (MIC): A deep learning tool for assigning ions and waters in cryo-EM and x-ray crystallography structures

Posted by dbos UCSF

Kavli Affiliate: Michael Keiser | Authors: Laura Shub, Wenjin Liu, Georgios Skiniotis, Michael J. Keiser and Michael J. Robertson | Summary: At sufficiently high resolution, x-ray crystallography and cryogenic electron microscopy are capable of resolving small spherical map features corresponding to either water or ions. Correct classification of these sites provides crucial insight for understanding […]


Continue.. Metric Ion Classification (MIC): A deep learning tool for assigning ions and waters in cryo-EM and x-ray crystallography structures

Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum

Posted by dbos Hopkins

Kavli Affiliate: Daeyeol Lee and Patricia Janak | Authors: Yifeng Cheng, Robin Magnard, Angela Langdon, Daeyeol Lee and Patricia H. Janak | Summary: Value-based decision-making relies on the striatum, where neural plasticity can be altered by chronic ethanol (EtOH) exposure, but the effects of such plasticity on striatal neural dynamics during decision-making remain unclear. This […]


Continue.. Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum

Representing the dynamics of natural marmoset vocal behaviors in frontal cortex

Posted by dbos UCSD / Salk

Kavli Affiliate: Cory Miller | Authors: Jingwen Li, Mikio Christian Aoi and Cory Miller | Summary: Here we tested the respective contributions of primate premotor and prefrontal cortex to support vocal behavior. We applied a model-based GLM analysis that better accounts for the inherent variance in natural, continuous behaviors to characterize the activity of neurons […]


Continue.. Representing the dynamics of natural marmoset vocal behaviors in frontal cortex

Social state gates vision using three circuit mechanisms in Drosophila

Posted by dbos Rockefeller

Kavli Affiliate: Vanessa Ruta | Authors: Catherine E. Schretter, Tom Hindmarsh Sten, Nathan Klapoetke, Mei Shao, Aljoscha Nern, Marisa Dreher, Daniel Bushey, Alice A. Robie, Adam L. Taylor, Kristin M. Branson, Adriane Otopalik, Vanessa Ruta and Gerald M. Rubin | Summary: Animals are often bombarded with visual information and must prioritize specific visual features based […]


Continue.. Social state gates vision using three circuit mechanisms in Drosophila