Cervical collagen network porosity assessed by SHG endomicroscopy distinguishes preterm and normal pregnancy – a pilot study

Posted by dbos Hopkins

Kavli Affiliate: Xingde Li | Authors: Wenxuan Liang, Yuehan Liu, Honghua Guan, Vorada Sakulsaengprapha, Katherine Luby-Phelps, Mala Mahendroo and Xingde Li | Summary: Background Preterm birth (PTB) is a global public health issue affecting millions of newborns every year. Orchestrated remodeling of the cervix is essential for normal pregnancy and birth, while PTB is closely […]


Continue.. Cervical collagen network porosity assessed by SHG endomicroscopy distinguishes preterm and normal pregnancy – a pilot study

An Amygdalar Oscillator Coordinates Cellular and Behavioral Rhythms

Posted by dbos Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Qiang Liu, Jiali Xiong, Dong Won Kim, Sang Soo Lee, Benjamin J. Bell, Chloe Alexandre, Seth Blackshaw, Alban Latremoliere and Mark N. Wu | Summary: Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN), in concert with local clocks throughout the body. While many brain regions exhibit […]


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Modulation of GABAA receptor trafficking by WWC2 reveals class-specific mechanisms of synapse regulation by WWC family proteins

Posted by dbos Hopkins

Kavli Affiliate: Richard Huganir | Authors: Thomas L Dunham, Julia R Wilkerson, Richard C Johnson, Richard L. Huganir and Lenora J Volk | Summary: WWC2 (WW and C2 domain-containing protein) is implicated in several neurological disorders, however its function in the brain has yet to be determined. Here, we demonstrate that WWC2 interacts with inhibitory […]


Continue.. Modulation of GABAA receptor trafficking by WWC2 reveals class-specific mechanisms of synapse regulation by WWC family proteins

Small molecule and cell contact-inducible systems for controlling expression and differentiation in stem cells

Posted by dbos UCSF

Kavli Affiliate: Hana El-Samad | Authors: Sarah S. Soliman, Devan H. Shah, Hana El-Samad and Zara Y. Weinberg | Summary: Synthetic developmental biology uses engineering approaches to understand multicellularity with goals ranging from recapitulating development to building synthetic organisms. Current approaches include engineering multicellular patterning, controlling differentiation, and implementing cooperative cellular behaviors in model systems. […]


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SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Qianyi E Zhang, Jared Lindenberger, Ruth Parsons, Bhishem Thakur, Rob Parks, Chan Soo Park, Xiao Huang, Salam Sammour, Katarzyna Janowska, Taylor N Spence, Robert J. Edwards, Mitchell Martin, Wilton B Williams, Sophie Gobeil, David C Montefiori, Bette Korber, Kevin O’Neil Saunders, Barton F Haynes, Barton F. Haynes, Rory Henderson […]


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Non-uniform contextual interactions in the visual cortex place fundamental limits on spatial vision

Posted by dbos Yale

Kavli Affiliate: Anirvan Nandy | Authors: Mitchell P Morton, Sachira Denagamage, Nyomi V Hudson and Anirvan S Nandy | Summary: A prevailing assumption in our understanding of how neurons in the primary visual cortex (V1) integrate contextual information is that such processes are spatially uniform. Conversely, perceptual phenomena such as visual crowding, the impaired ability […]


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Hypothalamic hormone deficiency enables physiological anorexia

Posted by dbos Yale

Kavli Affiliate: Elena Gracheva | Authors: Sarah M Mohr, Rafael Dai Pra, Maryann P Platt, Viktor V Feketa, Marya Shanabrough, Luis Varela, Ashley Kristant, Haoran Cao, Dana K Merriman, Tamas L Horvath, Sviatoslav N Bagriantsev and Elena O Gracheva | Summary: Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal […]


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Cell type-specific dynamics of prefrontal gamma synchrony during flexible behavior

Posted by dbos UCSF

Kavli Affiliate: Vikaas Sohal | Authors: Aarron Justin Phensy, Lara Louise Hagopian and Vikaas Singh Sohal | Summary: The prefrontal cortex (PFC) is required for many cognitive processes that are disrupted in conditions such as schizophrenia. The PFC is composed of neuronal networks which are organized by both local microcircuitry and inter-regional projections, within which […]


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How low can you go? Short-read polishing of Oxford Nanopore bacterial genome assemblies

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: George Bouras, Louise M Judd, Robert A Edwards, Sarah Vreugde, Timothy P. Stinear and Ryan R Wick | Summary: It is now possible to assemble near-perfect bacterial genomes using Oxford Nanopore Technologies (ONT) long reads, but short-read polishing is still required for perfection. However, the effect of short-read depth […]


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Developmental trajectory of cortical somatostatin interneuron function

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Alex Wang, Katie A. Ferguson, Jyoti Gupta, Michael J. Higley and Jessica A. Cardin | Summary: GABAergic inhibition is critical to the proper development of neocortical circuits. However, GABAergic interneurons are highly diverse and the developmental roles of distinct inhibitory subpopulations remain largely unclear. Dendrite-targeting, somatostatin-expressing interneurons (SST-INs) […]


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