A mathematical theory of relational generalization in transitive inference

Kavli Affiliate: Vincent Ferrera | Authors: Samuel Lippl, Kenneth Kay, Greg Jensen, Vincent P. Ferrera and L.F. Abbott | Summary: Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items (“compositional generalization”). This allows them to respond appropriately to radically novel circumstances and is fundamental […]


Continue.. A mathematical theory of relational generalization in transitive inference

Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations

Kavli Affiliate: Daeyeol Lee | Authors: James Webb, Paul Steffan, Benjamin Y Hayden, Daeyeol Lee, Caleb Kemere and Matthew McGinley | Summary: Foraging theory has been a remarkably successful approach to understanding the behavior of animals in many contexts. In patch-based foraging contexts, the marginal value theorem (MVT) shows that the optimal strategy is to […]


Continue.. Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations

Learning enhances behaviorally relevant representations in apical dendrites

Kavli Affiliate: Elizabeth Hillman | Authors: Sam E. Benezra, Kripa B. Patel, Citlali Pérez Campos, Elizabeth M. C. Hillman and Randy M Bruno | Summary: Learning alters cortical representations and improves perception. Apical tuft dendrites in Layer 1, which are unique in their connectivity and biophysical properties, may be a key site of learning-induced plasticity. […]


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Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Kavli Affiliate: Kathleen Cullen | Authors: Kazuya Ono, Amandine Jarysta, Natasha Hughes, Alma Jukic, Vanessa H.H. Chang, Michael R Deans, Ruth Anne Eatock, Kathleen E Cullen, Katie S Kindt and Basile Tarchini | Summary: Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect […]


Continue.. Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Robert A Edwards, Michael J. Roach, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Joel Brame, Anna Heintz-Buschart, Timothy R Cavagnaro, Elizabeth A Dinsdale, Michael P Doane, Nico Eisenhauer, Grace Mitchell, Bibishan Rai, Sunita Ramesh and Martin F Breed | Summary: Microbiomes are critical to the […]


Continue.. Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes

Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for spatially resolved cellular profiling using thinly cut sections have enabled […]


Continue.. Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

Generative interpolation and restoration of images using deep learning for improved 3D tissue mapping

Kavli Affiliate: Denis Wirtz | Authors: Saurabh Joshi, André Forjaz, Kyu Sang Han, Yu Shen, Daniel Xenes, Jordan Matelsky, Brock Wester, Arrate Munoz-Barrutia, Ashley L Kiemen, Pei-Hsun Wu and Denis Wirtz | Summary: The development of novel imaging platforms has improved our ability to collect and analyze large three-dimensional (3D) biological imaging datasets. Advances in […]


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Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

Kavli Affiliate: Stanley Prusiner | Authors: Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth and Carlo Condello | Summary: Down Syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, […]


Continue.. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J Crawford, Adrian Johnston, Wenxuan Du, Eban A Hanna, David Schell, Zeqi Wan, Ting-Hsi Chen, Fan Wu, Kehan Ren, Yeongseo Lim, Praful R Nair and Denis Wirtz | Summary: Immune cell-mediated killing of cancer cells in a solid tumor is prefaced by a multi-step infiltration cascade of invasion, […]


Continue.. A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Small extracellular vesicles promote stiffness-mediated metastasis

Kavli Affiliate: Denis Wirtz | Authors: Alexandra Sneider, Ying Liu, Bartholomew Starich, Wenxuan Du, Carolyn Marar, Najwa Faqih, Gabrielle E Ciotti, Joo Ho Kim, Sejal Krishnan, Salma Ibrahim, Muna Igboko, Alexus Locke, Daniel M Lewis, Hanna Hong, Michelle Karl, Raghav Vij, Gabriella C Russo, Praful R Nair, Estibaliz Gómez-de-Mariscal, Mehran Habibi, Arrate Munoz-Barrutia, Luo Gu, […]


Continue.. Small extracellular vesicles promote stiffness-mediated metastasis