Kavli Affiliate: Richard Huganir | Authors: Julia Brill, Blaise Clarke, Ingie Hong and Richard L. Huganir | Summary: SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through […]
Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]
Kavli Affiliate: Li Zhao | Authors: Qing Zhao, William de Nardo, Ruoyu Wang, Yi Zhong, Umur Keles, Li Na Zhao, Huiyi Tay, Sonia Youhanna, Mengchao Yan, Ye Xie, Youngrae Kim, Sungdong Lee, Rachel Liyu Lim, Guoshou Teo, Pradeep Naraya, Paul R Burton, Volker M Lauschke, Hyungwon Choi, Matthew J Watt and Philipp Kaldis | Summary: […]
Kavli Affiliate: John Reynolds | Authors: Emily S King, Jamie L Beros, Hakuei Fujiyama, John N Reynolds and Alexander D Tang | Summary: Background: Stroke is a leading cause of disability and stroke-induced changes in cortical excitability are thought to impede functional recovery. Identifying cellular targets that contribute to maladaptive excitability holds great potential for […]
Kavli Affiliate: Shai Shaham | Authors: Rashna Sharmin, Aladin Elkhalil, Sara Pena, Pranya Gaddipati, Ginger Clark, Pavak K Shah, Mark W Pellegrino, Shai Shaham and Piya Ghose | Summary: Polarized cells (such as neurons), defined by distinct compartments are, like many cell types, subject to developmental elimination, as in neurite pruning. The molecular mechanism behind […]
Kavli Affiliate: Arturo Alvarez-Buylla, Andrea Hasenstaub, and Michael Stryker | Authors: Benjamin Rakela, Jennifer Sun, Philine Marchetta, Arturo Alvarez-Buylla, Andrea R Hasenstaub and Michael P Stryker | Summary: Cortical interneurons play an important role in mediating the juvenile critical period for ocular dominance plasticity in the mouse primary visual cortex. Previously, we showed that transplantation […]
Kavli Affiliate: Rui Costa | Authors: Sara Moberg, Michele Garibbo, Camille Mazo, Ariel Gilad, Dietmar Schmitz, Rui Ponte Costa, Matthew E Larkum and Naoya Takahashi | Summary: Adaptive behavior is critically dependent on associative learning, where environmental cues are linked with subsequent positive or negative outcomes. In mammals, primary neocortical sensory areas serve as pivotal […]
Kavli Affiliate: Eiman Azim and Tatyana Sharpee | Authors: Mingchen Yao, Akira Nagamori, Eiman Azim, Tatyana Sharpee, Martyn Goulding, David Golomb and Graziana Gatto | Summary: Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal populations composing them […]
Kavli Affiliate: Saul Kato | Authors: Jason Adhinarta, Jizheng Dong, Tianxiao He, Daniel Sprague, JIa Wan, Hyun Jee Lee, Zikai Yu, Hang Lu, Eviatar Yemini, Saul Kato, Erdem Varol and Donglai Wei | Summary: The nematode C. elegans is a well-studied model organism for characterizing the structure, connectivity, and function of a complete nervous system. […]
Kavli Affiliate: John Reynolds | Authors: Yan-Feng Zhang, Jean-Philippe Dufour, Peter Zatka-Haas, Peter Redgrave, Melony J Black, Armin Lak, Ed Mann, Stephanie J Cragg, Wickliffe Abraham and John NJ Reynolds | Summary: In classical Pavlovian conditioning, it is well-established that midbrain dopamine neurons respond to conditioned stimuli (CS) that predict a reward. However, how the […]