Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience

Posted by klaurent UCSF

Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]


Continue.. Brain substates induced by DMT relate to sympathetic output and meaningfulness of the experience

Structure and function of an intermediate GPCR-G protein complex

Posted by dbos UCSF

Kavli Affiliate: Yifan Cheng | Authors: Maxine Bi, Xudong Wang, Jinan Wang, JUN xu, Wenkai Sun, Victtor Ayo Adediwrua, Yinglong Miao, Yifan Cheng and Libin Ye | Summary: Despite hundreds of GPCR-Gαβγ complex structures, these snapshots uniquely capture the fully activated complex. Consequently, a comprehensive understanding of the conformational transitions during GPCR activation and the […]


Continue.. Structure and function of an intermediate GPCR-G protein complex

Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Posted by dbos Yale

Kavli Affiliate: Pietro De Camilli | Authors: Hanieh Falahati, Yumei Wu and Pietro De Camill | Summary: Abstract The endoplasmic reticulum (ER) is a continuous cellular endomembrane network that displays focal specializations. Most notable examples of such specializations include the spine apparatus of neuronal dendrites, and the cisternal organelle of axonal initial segments. Both organelles […]


Continue.. Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation

Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

Posted by dbos Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Vered Kellner, Patrick Parker, Xuelong Mi, Guoqiang Yu, Gesine Saher and Dwight E Bergles | Summary: Abstract Afferent neurons in developing sensory organs exhibit a prolonged period of burst firing prior to the onset of sensory experience. This intrinsically generated activity propagates from the periphery through central processing centers […]


Continue.. Conservation of neuron-astrocyte coordinated activity among sensory processing centers of the developing brain

Neural correlates of individual facial recognition in a social wasp

Posted by dbos Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Christopher M. Jernigan, Winrich A. Freiwald and Michael J. Sheehan | Summary: Abstract Individual recognition is critical for social behavior across species. Whether recognition is mediated by circuits specialized for social information processing has been a matter of debate. Here we examine the neurobiological underpinning of individual visual facial […]


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Cellular and Molecular Basis of Leptin Resistance

Posted by klaurent Rockefeller

Kavli Affiliate: Jeffrey M. Friedman | Authors: Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Ji-Dung Luo, Joshua D. Rabinowitz and Jeffrey M. Friedman | Summary: Obese humans and diet induced obese mice (DIO) have high leptin levels and fail to respond to the exogenous hormone suggesting that obesity is caused by leptin resistance, the […]


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Spyglass: a data analysis framework for reproducible and shareable neuroscience research

Posted by dbos UCSF

Kavli Affiliate: Loren Frank | Authors: Kyu Hyun Lee, Eric L. Denovellis, Ryan Ly, Jeremy Magland, Jeff Soules, Alison E Comrie, Daniel P Gramling, Jennifer A Guidera, Rhino Nevers, Philip Adenekan, Chris Brozdowski, Samuel R Bray, Emily Monroe, Ji Hyun Bak, Michael Coulter, Xulu Sun, Emrey Broyles, Donghoon Shin, Sharon Chiang, Cristofer Holobetz, Andrew Tritt, […]


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Sliding windows analysis can undo the effects of preprocessing when applied to fMRI data

Posted by dbos Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Martin Lindquist | Summary: Resting-state fMRI (rs-fMRI) data is used to study the intrinsic functional connectivity (FC) in the human brain. Recently, interest has focused on studying the temporal dynamics of FC on short timescales, ranging from seconds to minutes. These studies of time-varying FC (TVFC) have enabled the […]


Continue.. Sliding windows analysis can undo the effects of preprocessing when applied to fMRI data

The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Posted by dbos UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Anjali Sandhu, Xiaohui Lyu, Xinghaoyun Wan, Xuefeng Meng, Ngang Heok Tang, Gilberto Gonzalez, Ishana N Syed, Lizhen Chen, Yishi Jin and Andrew D Chisholm | Summary: Microtubules (MTs) are dynamic components of the cytoskeleton and play essential roles in morphogenesis and maintenance of tissue and cell integrity. Despite recent […]


Continue.. The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Increased functional integration of emotional control network in late adulthood

Posted by dbos NTNU

Kavli Affiliate: Maryam Ziaei | Authors: Leona R Baetz, Shuer Ye, Xiaqing Lan and Maryam Ziaei | Summary: Across the adult lifespan, there are changes in how emotions are perceived and regulated. As individuals age, there is an observed improvement in emotion regulation and overall quicker recovery from negative emotions. While previous studies have shown […]


Continue.. Increased functional integration of emotional control network in late adulthood