Coumarin as a general switching auxiliary to prepare photochromic and spontaneously blinking fluorophores

Posted by dbos UCSD / Salk

Kavli Affiliate: Timothy Brown | Authors: Fadi Jradi, Brian P English, Timothy A Brown, Jesse Arron, Satya Khuon, James A Galbraith, Catherine G Galbraith and Luke D Lavis | Summary: Single-molecule localization microscopy (SMLM) uses activatable or switchable fluorophores to create non-diffraction limited maps of molecular location in biological samples. Despite the utility of this […]


Continue.. Coumarin as a general switching auxiliary to prepare photochromic and spontaneously blinking fluorophores

Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

Posted by dbos Yale

Kavli Affiliate: Flora Vaccarino | Authors: Yifan Wang, Liana Fasching, Feinan Wu, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F. Leckman, Alexej Abyzov and Flora M. Vaccarino | Summary: Tourette syndrome (TS) is a disorder of high-order integration of sensory, motor, and cognitive functions afflicting as many as 1 in 150 children and characterized by […]


Continue.. Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette syndrome

BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

Posted by dbos Columbia

Kavli Affiliate: Wei Min | Authors: Sushmitha Sriramulu, Shivani Thoidingjam, Wei-Min Chen, Oudai Hassan, Farzan Siddiqui, Stephen L Brown, Benjamin Movsas, Michael D Green, Anthony J Davis, Corey Speers, Eleanor Walker and Shyam Nyati | Summary: Background Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). […]


Continue.. BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer

Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Diana M. Smith, Pravesh Parekh, Joseph Kennedy, Robert J. Loughnan, Oleksandr Frei, Thomas E. Nichols, Ole A. Andreassen, Terry L. Jernigan and Anders M. Dale | Summary: The relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal […]


Continue.. Partitioning variance in cortical morphometry into genetic, environmental, and subject-specific components using a large adolescent sample

Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory

Posted by dbos NTNU

Kavli Affiliate: Menno Witter | Authors: Daniel Reznik, Piotr Majka, Marcello GP Rosa, Menno P Witter and Christian F Doeller; | Summary: Throughout mammalian evolution, the hippocampal region, unlike the neocortex, largely preserved its cytoarchitectural organization and its role in mnemonic functions. This contrast raises the possibility that the hippocampal region receives different types of […]


Continue.. Phylogeny of neocortical-hippocampal projections provides insight in the nature of human memory

An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior

Posted by dbos UCSD / Salk

Kavli Affiliate: Kay Tye | Authors: Alexander Lin, Cyril Akafia, Olga Dal Monte, Siqi Fan, Nicholas Fagan, Philip Putnam, Kay M. Tye, Steve Chang, Demba Ba and AZA Stephen Allsop; | Summary: In neuroscience, understanding how single-neuron firing contributes to distributed neural ensembles is crucial. Traditional methods of analysis have been limited to descriptions of […]


Continue.. An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior

Structure of the Flotillin Complex in a Native Membrane Environment

Posted by dbos Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Ziao Fu and Roderick MacKinnon; | Summary: In this study we used cryo-electron microscopy to determine the structures of the Flotillin protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily, from cell-derived vesicles without detergents. It forms a right-handed helical barrel consisting of 22 pairs of […]


Continue.. Structure of the Flotillin Complex in a Native Membrane Environment

A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

Posted by dbos UCSF

Kavli Affiliate: Joshua Berke | Authors: Mariana Duhne, Ali Mohebi, Kyoungjun Kim, Lilian Pelattini and Joshua D. Berke; | Summary: Movement, motivation and reward-related learning depend strongly on striatal dopamine and acetylcholine. These neuromodulators each regulate the other, and disturbances to their coordinated signals contribute to human disorders ranging from Parkinson’s Disease to depression and […]


Continue.. A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors

Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology

Posted by dbos UCSD / Salk

Kavli Affiliate: Yishi Jin | Authors: Seungmee Park, Nathaniel Noblett, Lauren Pitts, Antonio Colavita, Ann M Wehman, Yishi Jin and Andrew D Chishol/p> | Summary: Mature neurons maintain their distinctive morphology for extended periods in adult life. Compared to developmental neurite outgrowth, axon guidance, and target selection, relatively little is known of mechanisms that maintain […]


Continue.. Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology