Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Posted by dbos Hopkins

Kavli Affiliate: Jin Kang | Authors: Sang-Hun Lee, Young-Jin Kang and Bret N Smith | Summary: Parvalbumin-positive (PV+) GABAergic interneurons in the dentate gyrus provide powerful perisomatic inhibition of dentate granule cells (DGCs) to prevent overexcitation and maintain the stability of dentate gyrus circuits. Most dentate PV+ interneurons survive status epilepticus, but surviving PV+ interneuron […]


Continue.. Activation of hypoactive parvalbumin-positive fast-spiking interneuron restores dentate inhibition to prevent epileptiform activity in the mouse intrahippocampal kainate model of temporal lobe epilepsy

Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Lucie Dequiedt, Andre Forjaz, Jamie O. Lo, Owen J McCarty, Pei-Hsun Wu, Avi Rosenberg, Denis Wirtz and Ashley L. Kiemen | Summary: Kidneys are among the most structurally complex organs in the body. Their architecture is critical to ensure proper function and is often impacted by diseases such as […]


Continue.. Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures

Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

Posted by dbos UCSF

Kavli Affiliate: Xin Duan | Authors: Dong Liu, Hannah C. Webber, Fuyun Bian, Yangfan Xu, Manjari Prakash, Xue Feng, Ming Yang, Hang Yang, In-Jee You, Liang Li, Liping Liu, Pingting Liu, Haoliang Huang, Chien-Yi Chang, Liang Liu, Sahil H. Shah, Anna La Torre, Derek S. Welsbie, Yang Sun, Xin Duan, Jeffrey L Goldberg, Marcus Braun, […]


Continue.. Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

A mathematical theory of relational generalization in transitive inference

Posted by klaurent Columbia

Kavli Affiliate: Vincent Ferrera | Authors: Samuel Lippl, Kenneth Kay, Greg Jensen, Vincent P. Ferrera and L.F. Abbott | Summary: Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items (“compositional generalization”). This allows them to respond appropriately to radically novel circumstances and is fundamental […]


Continue.. A mathematical theory of relational generalization in transitive inference

Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations

Posted by dbos Hopkins

Kavli Affiliate: Daeyeol Lee | Authors: James Webb, Paul Steffan, Benjamin Y Hayden, Daeyeol Lee, Caleb Kemere and Matthew McGinley | Summary: Foraging theory has been a remarkably successful approach to understanding the behavior of animals in many contexts. In patch-based foraging contexts, the marginal value theorem (MVT) shows that the optimal strategy is to […]


Continue.. Foraging Under Uncertainty Follows the Marginal Value Theorem with Bayesian Updating of Environment Representations

Learning enhances behaviorally relevant representations in apical dendrites

Posted by dbos Columbia

Kavli Affiliate: Elizabeth Hillman | Authors: Sam E. Benezra, Kripa B. Patel, Citlali Pérez Campos, Elizabeth M. C. Hillman and Randy M Bruno | Summary: Learning alters cortical representations and improves perception. Apical tuft dendrites in Layer 1, which are unique in their connectivity and biophysical properties, may be a key site of learning-induced plasticity. […]


Continue.. Learning enhances behaviorally relevant representations in apical dendrites

Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Posted by dbos Hopkins

Kavli Affiliate: Kathleen Cullen | Authors: Kazuya Ono, Amandine Jarysta, Natasha Hughes, Alma Jukic, Vanessa H.H. Chang, Michael R Deans, Ruth Anne Eatock, Kathleen E Cullen, Katie S Kindt and Basile Tarchini | Summary: Otolith organs in the inner ear and neuromasts in the fish lateral-line harbor two populations of hair cells oriented to detect […]


Continue.. Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function

Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes

Posted by dbos UCSF

Kavli Affiliate: Robert Edwards | Authors: Craig Liddicoat, Robert A Edwards, Michael J. Roach, Jake M Robinson, Kiri Joy Wallace, Andrew D Barnes, Joel Brame, Anna Heintz-Buschart, Timothy R Cavagnaro, Elizabeth A Dinsdale, Michael P Doane, Nico Eisenhauer, Grace Mitchell, Bibishan Rai, Sunita Ramesh and Martin F Breed | Summary: Microbiomes are critical to the […]


Continue.. Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes

Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Eduarda Vaz, Valentina Matos Romero, Saurabh Joshi, Alicia M. Braxton, Ann C. Jiang, Kohei Fujikura, Toby Cornish, Seung-Mo Hong, Ralph H. Hruban, Pei-Hsun Wu, Laura D. Wood, Ashley L. Kiemen and Denis Wirtz | Summary: Methods for spatially resolved cellular profiling using thinly cut sections have enabled […]


Continue.. Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues