Kavli Affiliate: Jean Fan and Laurent Younes | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Summary: Definition of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. Marker […]
Kavli Affiliate: Donald Geman and Laurent Younes | Authors: Lanlan Ji, An Wang, Shreyash Sonthalia, Daniel Q Naiman, Laurent Younes, Carlo Colantuoni and Donald Geman | Summary: Accurate identification of cell classes across the tissues of living organisms is central in the analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across biomedicine. Such […]
Kavli Affiliate: Jean Fan | Authors: Katy Boerner, Philip D Blood, Jonathan C Silverstein, Matthew Ruffalo, Sarah A Teichmann, Gloria Pryhuber, Ravi S Misra, Jeffrey M Purkerson, Jean Fan, John W Hickey, Gesmira Molla, Chuan Xu, Yun Zhang, Griffin M Weber, Yashvardhan Jain, Danial Qaurooni, Yongxin Kong, Andreas Bueckle and Bruce W Herr II | […]
Kavli Affiliate: Dwight Bergles | Authors: Saman Hussain, Miloslav Sedlacek, Runjia Cui, Wendy Zhang-Hooks, Dwight E Bergles, Jung-Bum Shin, Katie Kindt and Bechara Kachar | Summary: The hair bundle of auditory and vestibular hair cells converts mechanical stimuli into electrical signals through mechanoelectrical transduction (MET). The MET apparatus is built around a tip link that […]
Kavli Affiliate: Adam Gazzaley | Authors: Lorenzo Pasquini, Alexander Simon, Courtney Gallen, Hannes Kettner, Leor Roseman, Adam Gazzaley, Robin Carhart-Harris and Christopher Timmermann | Summary: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory […]
Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: We report the existence of a working memory system in the nematode C. elegans that is employed for deferred action in a […]
Kavli Affiliate: Mark Ellisman | Authors: Tylor R Lewis, Natalia V Klementieva, Sebastien Phan, Carson M Castillo, Keun-Young Kim, Lauren Y Cao, Mark Ellisman, Vadim Y Arshavsky and Oleg Alekseev | Summary: The first steps in vision take place in photoreceptor cells, which are highly compartmentalized neurons exhibiting significant structural variation across species. The light-sensitive […]
Kavli Affiliate: Keri Martinowich | Authors: Nicholas J. Eagles, Svitlana V. Bach, Madhavi Tippani, Prashanti Ravichandran, Yufeng Du, Ryan A. Miller, Thomas Hyde, Stephanie C. Page, Keri Martinowich and Leonardo Collado-Torres | Summary: Background Visium is a widely-used spatially-resolved transcriptomics assay available from 10x Genomics. Standard Visium capture areas (6.5mm by 6.5mm) limit the survey […]
Kavli Affiliate: Kevin Bender | Authors: Ryan Alexander and Kevin Bender | Summary: Opioids regulate circuits associated with motivation and reward across the brain. Of the opioid receptor types, delta opioid receptors (DORs) appear to have a unique role in regulating the activity of circuits related to reward without a liability for abuse. In neocortex, […]
Kavli Affiliate: Mark Ellisman | Authors: Eric KF Donahue, Nathaniel L Hepowit, Brennen Keuchel, Alexandra G Mulligan, Derek J Johnson, Mark Ellisman, Rafael Arrojo e Drigo, Jason A MacGurn and Kristopher Burkewitz | Summary: The endoplasmic reticulum (ER) comprises an array of structurally distinct subdomains, each with characteristic functions. While altered ER-associated processes are linked […]