Kavli Affiliate: Terry Jernigan, Anders Dale, Wesley Thompson | Authors: Chun Chieh Fan, Clare E Palmer, John Iverson, Diliana Pecheva, Oleksandr Frei, Dominic Holland, Wesley K Thompson, Donald Hagler, Terry L Jernigan, Ole Andreassen, Anders M. Dale and Thomas Nichols | Summary: The linear mixed effects model (LME) is a versatile modeling approach to deal […]
Kavli Affiliate: Daniele Canzio | Authors: Lea Kiefer, Gabrielle Isabelle F. Servito, Sandy M Rajkumar, Jennifer Langen, Anna Chiosso, Alexander Buckley, Elizabeth S. Cha, Adan Horta, Michael H Mui and Daniele Canzio | Summary: Clustered Protocadherin (Pcdh) proteins act as cell-surface recognition barcodes for neural circuit formation. Neurites expressing the same barcode repel each other, […]
Kavli Affiliate: Gabriel Silva | Authors: Connor Bernard, Gabriel Silva Santos, Jacques Deere, Roberto Rodriguez-Caro, Pol Capdevila, Erik Kusch, Samuel Gascoigne, John Jackson and Roberto Salguero-Gomez | Summary: The ecological sciences have joined the big data revolution. However, despite exponential growth in data availability, broader interoperability amongst datasets is still needed to unlock the potential […]
Kavli Affiliate: Kristofer Bouchard | Authors: Jesse A Livezey, Pratik Singh Sachdeva, Maximilian E Dougherty, Mathew T Summers and Kristofer E Bouchard | Summary: The brain represents the world through the activity of neural populations. Correlated variability across simultaneously recorded neurons (noise correlations) has been observed across cortical areas and experimental paradigms. Many studies have […]
Kavli Affiliate: Pietro DeCamilli | Authors: Shujun Cai, Yumei Wu, Andres Guillen-Samander, William F Hancock-Cerutti, Jun Liu and Pietro De Camilli | Summary: VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like mechanism. Direct evidence for this hypothesis […]
Kavli Affiliate: Karen Christman | Authors: Holly Sullivan, Yifei Liang, Kendra Worthington, Colin Luo, Nathan C Gianneschi and Karen Christman | Summary: In this paper, we describe block copolymer amphiphiles consisting of a hydrophilic matrix metalloproteinase (MMP) peptide substrate, and a hydrophobic small molecule MMP inhibitor PD166793 for the treatment of acute myocardial infarction. These […]
Kavli Affiliate: Erich Jarvis | Authors: Erich D. Jarvis, Giulio Formenti, Arang Rhie, Andrea Guarracino, Chentao Yang, Jonathan Wood, Alan Tracey, Francoise Thibaud-Nissen, Mitchell R Vollger, David Porubsky, Haoyu Cheng, Mobin Asri, Glennis A Logsdon, Paolo Carnevali, Mark Chaisson, Chen-Shan Chin, Sarah Cody, Joanna Collins, Peter Ebert, Merly Escalona, Olivier Fedrigo, Robert S Fulton, Lucinda […]
Kavli Affiliate: Philip Starr | Authors: James J. Sermon, Maria Olaru, Juan Anso, Simon Little, Rafal Bogacz, Philip A. Starr, Timothy Denison and Benoit Duchet | Summary: Background Entrainment of brain oscillations has been hypothesised as a potential mechanism of neuromodulation. While neuromodulation has been shown to be an effective therapy for a variety of […]
Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 […]
Kavli Affiliate: Wei Min | Authors: Clark D Wells, Kevin Lange, Abigail F Thompson, Wei Min Xu, Sherry G Clendenon, John S Underwood, Peter Harris, Britney-Shea Herbert, James A. Glazier, Angela Wandinger-Ness and Robert L Bacallao | Summary: Despite substantial progress in identifying and understanding causative mutations in autosomal dominant polycystic kidney disease (ADPKD), little […]