Kavli Affiliate: Michael Shadlen | Authors: Gabriel M Stine, Eric M Trautmann, Danique Jeurissen and Michael N Shadlen | Summary: The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of evidence accumulation are well established in association cortex, but the site and mechanism of termination is unknown. […]
Kavli Affiliate: Edvard Moser, May Britt Moser, Ragnhild Leifsdottir, Horst Obenhaus | Authors: Soledad Gonzalo Cogno, Horst A. Obenhaus, Ragnhild Irene Jacobsen, Flavio Donato, May-Britt Moser and Edvard I. Moser | Summary: The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity […]
Kavli Affiliate: Joshua Berke | Authors: Wei Wei, Ali Mohebi and Joshua Berke | Summary: Dopamine input to striatum can encode reward prediction error, a critical signal for updating predictions of future rewards. However, it is unclear how this mechanism handles the need to make predictions, and provide feedback, over multiple time horizons: from seconds […]
Kavli Affiliate: Erich Jarvis | Authors: Anjana C. Karawita, Yuanyuan Cheng, Keng Yih Chew, Arjun Challgula, Robert Kraus, Ralf C. Mueller, Marcus Z. W. Tong, Katina D. Hulme, Helle Beielefeldt-Ohmann, Lauren E. Steele, Melanie Wu, Julian DJ Sng, Ellesandra Noye, Timothy J. Bruxner, Gough G. Au, Suzanne Lowthe, Julie Blommaert, Alexander Suh, Alexander J. McCauley, […]
Kavli Affiliate: Karen Christman | Authors: Pamela Duran, Emma Zelus, Saya French, Lindsey Burnett, Karen Christman and Marianna Alperin | Summary: Objectives: Childbirth is a key risk factor for pelvic floor muscle (PFM) injury and dysfunction, and subsequent pelvic floor disorders (PFDs). Multiparity further exacerbates these risks. Using the pre-clinical rat model of simulated birth […]
Kavli Affiliate: Michela Gallagher | Authors: Dong-Hee Kim, In-Beom Jin, Nam-Heon Kim, Yong-Jae Jeon, Bo-Ryoung Choi, Michela Gallagher and Jung-Soo Han | Summary: The lateral habenula (LHb) has been implicated in conditioned inhibition. Here, the modulating effects of LHb activity on the association of a conditioned stimulus (CS) with the nonoccurrence of an unconditioned stimulus […]
Kavli Affiliate: Adam Aron | Authors: Pria L Daniel, James J Bonaiuto, Sven Bestmann, Adam R Aron and Simon Little | Summary: Flexibility of behavior and the ability to rapidly switch actions is critical for adaptive living in humans. It is well established that the right-inferior frontal gyrus (R-IFG) is recruited during outright action-stopping, relating […]
Kavli Affiliate: Joshua Berke | Authors: Bon-Mi Gu and Joshua D. Berke | Summary: Suppressing actions is essential for flexible behavior. Multiple neural circuits involved in behavioral inhibition converge upon a key basal ganglia output nucleus, the substantia nigra pars reticulata (SNr). To examine how changes in basal ganglia output contribute to self-restraint, we recorded […]
Kavli Affiliate: David Linden | Authors: J. Kopal, K. Kumar, K. Saltoun, C. Modenato, C. A. Moreau, S. Martin-Brevet, G. Huguet, M. Jean-Louis, C.O. Martin, Z. Saci, N. Younis, P. Tamer, E. Douard, A. M. Maillard, B. Rodriguez-Herreros, A. Pain, S. Richetin, 16p11.2 European Consortium, Simons Searchlight Consortium, L. Kushan, A. I. Silva, M. B. […]
Kavli Affiliate: John Serences | Authors: Margaret M. Henderson, Rosanne L. Rademaker and John T. Serences | Summary: Working memory provides flexible storage of information in service of upcoming behavioral goals. Some models propose specific fixed loci and mechanisms for the storage of visual information in working memory, such as sustained spiking in parietal and […]