Neuroscience – Page 124 – Kavli Institute Pre-Print Publications

ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis

Posted by klaurent March 20, 2022April 4, 2022Yale

Kavli Affiliate: Flora Vaccarino | Authors: Alexandre Jourdon, Feinan Wu, Jessica Mariani, Davide Capauto, Scott Norton, Livia Tomasini, Anahita Amiri, Milovan Suvakov, Jeremy Schreiner, Yeongjun Jang, Cindy Khanh Nguyen, Elise M Cummings, Gloria Han, Kelly Powell, Anna Szekely, James C McPartland, Kevin Pelphrey, Katarzyna Chawarska, Pamela Ventola, Alexej Abyzov and Flora M Vaccarino | Summary: […]

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Persistent postnatal migration of interneurons into the human entorhinal cortex

Posted by klaurent March 20, 2022March 28, 2022UCSF

Kavli Affiliate: Arturo Alvarez-Buylla | Authors: Marcos Assis Nascimento, Sean Biagiotti, Vicente Herranz-Perez, Raymund Bueno, Chun Jimmie Ye, Taylor Abel, Juan S Rubio Moll, Jose Manuel Garcia-Verdugo, Eric J. Huang, Arturo Alvarez-Buylla and Shawn F Sorrells | Summary: The entorhinal cortex (EC) is a highly-interconnected hub for multisensory integration and memory processing1-3, containing diverse neuronal […]

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KAT5 activity regulates G0-like states in human gliomas

Posted by klaurent March 19, 2022March 28, 2022Hopkins

Kavli Affiliate: Jin Kang | Authors: Anca Mihalas, Sonali Arora, Samantha O’Connor, Heather Feldman, John Bassett, Kelly Mitchell, Kang Jin, Pia Hoellerbauer, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Bruce J Aronow, Christopher J Plaisier, Anoop Patel and PATRICK PADDISON | Summary: In solid tumors, G0-like cell populations likely play important roles […]

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Synergistic effect of mutations in the Parkinson’s disease-linked endocytic proteins synaptojanin 1 (PARK20) and auxilin (PARK19)

Posted by klaurent March 18, 2022March 28, 2022Yale

Kavli Affiliate: Pietro DeCamilli | Authors: Xin Yi Ng, Yumei Wu, Youneng Lin, Sidra Mohamed Yaqoob, Lois E. Greene, Pietro De Camilli and Mian Cao | Summary: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically-enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and […]

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Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer’s Disease

Posted by klaurent March 18, 2022March 28, 2022Hopkins, NTNU

Kavli Affiliate: Michael Miller, Susumu Mori, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Claire Chen, Eileen Xu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael Miller | Summary: Since Braak’s initial histological observations, it has been recognized that Alzheimer’s disease (AD) neurofibrillary tangles (NFTs) appear in the medial temporal lobe (MTL) […]

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Hypomyelination reduces parvalbumin interneuron density and auditory cortex inhibitory function

Posted by klaurent March 18, 2022March 28, 2022Hopkins

Kavli Affiliate: Patrick Kanold | Authors: Beatriz C Borges, Xiangying Meng, Patrick Long, Patrick O Kanold and Gabriel Corfas | Summary: For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on excitatory cells. Recent evidence showed that axons of inhibitory neurons in the neocortex are […]

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Dissecting neural computations of the human auditory pathway using deep neural networks for speech

Posted by klaurent March 15, 2022March 28, 2022UCSF

Kavli Affiliate: Edward Chang | Authors: Yuanning Li, Gopala K Anumanchipalli, Abdelrahman Mohamed, Junfeng Lu, Jinsong Wu and Edward F Chang | Summary: The human auditory system extracts rich linguistic abstractions from the speech signal. Traditional approaches to understand this complex process have used classical linear feature encoding models, with limited success. Artificial neural networks […]

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IReNA: integrated regulatory network analysis of single-cell transcriptomes

Posted by klaurent March 15, 2022March 28, 2022Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Cjunyao jiang, Pin Lyu, Jinlian Li, Sunan Huang, Seth Blackshaw, Jiang Qian and Jie Wang | Summary: Although single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase accessible chromatin using sequencing (scATAC-seq) have been widely used, few methods can reliably integrate these data to perform regulatory network analysis. Here, […]

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FEMA: Fast and efficient mixed-effects algorithm for population-scale whole brain imaging data

Posted by klaurent March 14, 2022March 28, 2022UCSD / Salk

Kavli Affiliate: Terry Jernigan, Anders Dale, Wesley Thompson | Authors: Chun Chieh Fan, Clare E Palmer, John Iverson, Diliana Pecheva, Oleksandr Frei, Dominic Holland, Wesley K Thompson, Donald Hagler, Terry L Jernigan, Ole Andreassen, Anders M. Dale and Thomas Nichols | Summary: The linear mixed effects model (LME) is a versatile modeling approach to deal […]

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Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiring

Posted by klaurent March 11, 2022March 21, 2022UCSF

Kavli Affiliate: Daniele Canzio | Authors: Lea Kiefer, Gabrielle Isabelle F. Servito, Sandy M Rajkumar, Jennifer Langen, Anna Chiosso, Alexander Buckley, Elizabeth S. Cha, Adan Horta, Michael H Mui and Daniele Canzio | Summary: Clustered Protocadherin (Pcdh) proteins act as cell-surface recognition barcodes for neural circuit formation. Neurites expressing the same barcode repel each other, […]

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