Fast rule switching and slow rule updating in a perceptual categorization task

Kavli Affiliate: Marcelo Mattar | Authors: Flora Bouchacourt, Sina Tafazoli, Marcelo Gomes Mattar, Timothy J Buschman and Nathaniel Douglass Daw | Summary: Abstract To adapt to a changing world, we must be able to switch between rules already learned and, at other times, learn rules anew. Often we must do both at the same time, […]


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A retroviral origin of vertebrate myelin

Kavli Affiliate: David Rowitch | Authors: Tanay Ghosh, Rafael G Almeida, Chao Zhao, Abdelkrim Mannioui, Elodie Martin, Alex Fleet, Ginez Gonzalez M, David H Rowitch, Katherine Stott, Ian Adams, Bernard Zalc, Nick Goldman, David A Lyons and Robin JM Franklin | Summary: Abstract Myelin, the insulating sheath that surrounds neuronal axons, is produced by oligodendrocytes […]


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Laminar Mechanisms of Saccadic Suppression in Primate Visual Cortex

Kavli Affiliate: John Reynolds | Authors: Sachira Denagamage, Mitchell P. Morton, John H. Reynolds, Monika P. Jadi and Anirvan S. Nandy | Summary: Saccades are a ubiquitous and crucial component of our visual system, allowing for the efficient deployment of the fovea and its accompanying neural resources. Initiation of a saccade is known to cause […]


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Co-Delivery of Synergistic Antimicrobials with Polyelectrolyte Nanocomplexes to Treat Bacterial Biofilms and Lung Infections

Kavli Affiliate: Tejal Desai | Authors: Joel A Finbloom, Preethi Raghavan, Michael Kwon, Bhushan N Kharbikar, Michelle A Yu and Tejal A Desai | Summary: Abstract New approaches are needed to treat bacterial biofilm infections, particularly those of Pseudomonas aeruginosa (PA), which have high rates of antimicrobial resistance and are commonly found in chronic wound […]


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Transcriptional and mutational signatures of the aging germline

Kavli Affiliate: Li Zhao | Authors: Evan Witt, Christopher B Langer, Nicolas Svetec and Li Zhao | Summary: Abstract Aging is a complex biological process that is accompanied by changes in gene expression and mutational load. In many species, including humans, older fathers pass on more paternally-derived de novo mutations; however, the cellular basis and […]


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Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy

Kavli Affiliate: Edward Chang | Authors: DANQING ZHU, David H Brookes, Akosua Busia, Ana Carneiro, Clara Fannjiang, Galina Popova, David Shin, Edward F Chang, Tomasz J. Nowakowski, Jennifer Listgarten and David V Schaffer | Summary: Abstract Adeno-associated viruses (AAVs) hold tremendous promise as delivery vectors for clinical gene therapy, but they need improvement. AAVs with […]


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Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes

Kavli Affiliate: John Reynolds | Authors: Kandarp Dave, Donna B Stolz, Venugopal R Venna, Victoria A. Quaicoe, Michael E Maniskas, Michael John Reynolds, Riyan Babidhan, Duncan X Dobbins, Maura N. Farinelli, Abigail Sullivan, Tarun N. Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K Leak, Sruti Shiva, Louise D McCullough and Devika Soundara Manickam | […]


Continue.. Mitochondria-containing EVs Protect Brain Endothelial Cells and Reduce Mouse Brain Infarct Sizes

Extracellular Vesicle (EV) Mitochondria and EV/HSP27 Mixtures Protect the Ischemic Brain Endothelium

Kavli Affiliate: John Reynolds | Authors: Kandarp Dave, Donna B Stolz, Michael John Reynolds, Riyan Babidhan, Duncan X Dobbins, Tarun N. Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K Leak, Sruti Shiva and Devika Soundara Manickam | Summary: Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain […]


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A positively Tuned Voltage Indicator Reveals Electrical Correlates of Calcium Activity in the Brain

Kavli Affiliate: Attila Losonczy | Authors: S. Wenceslao Evans, Dongqing Shi, Mariya Chavarha, Mark H. Plitt, Jiannis Taxidis, Blake Madruga, Siri C. van Keulen, Michelle M. Pang, Sharon Su, Fuu-Jiun Hwang, Guofeng Zhang, Austin Reese, Lagnajeet Pradhan, Jiang Lan Fan, Sungmoo Lee, Yu Liu, Carl-Mikael Suomivuori, Dongyun Jiang, Adrian Negrean, Sui Wang, Na Ji, Thomas […]


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HERBS: Histological E-data Registration in rodent Brain Spaces

Kavli Affiliate: Jonathan Whitlock, Jingyi Guo, Pearl Saldanha | Authors: Jingyi Guo Fuglstad, Pearl Saldanha, Jacopo Paglia and Jonathan R. Whitlock | Summary: Abstract Recording technologies for rodents have seen huge advances in the last decade, allowing users to sample thousands of neurons simultaneously from multiple brain regions. This has prompted the need for digital […]


Continue.. HERBS: Histological E-data Registration in rodent Brain Spaces