The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

Posted by klaurent UCSD / Salk

Kavli Affiliate: Jose Suarez Lopez | Authors: Selim Chaib, José Alberto López-Domínguez, Marta Lalinde, Neus Prats, Inés Marín, Kathleen Meyer, María Isabel Muñoz, Mònica Aguilera, Lidia Mateo, Camille Stephan-Otto Attolini, Susana Llanos, Marta Escorihuela, Sandra Pérez-Ramos, Fatima Al-Shahrour, Timothy P Cash, Tamara Tchkonia, James L Kirkland, Joaquín Arribas and Manuel Serrano | Summary: Abstract Anti-cancer […]


Continue.. The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

Astrocyte-like CEPsh glia responds to the stressful environments

Posted by klaurent UCSF

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, RASHMI CHANDRA and Noelle L’Etoile | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia responds to the stressful environments

Astrocyte-like CEPsh glia respond to stress

Posted by klaurent UCSF

Kavli Affiliate: Noelle Letoile | Authors: Evangeline Chien, Angel Jacob Garcia, Noelle L’Etoile and RASHMI CHANDRA | Summary: Abstract While astrocytes are known to be important for development and nourishment of the nervous system, the field is just beginning to explore how astrocytes respond to environmental stimuli. Using Caenorhabditis elegans and their astrocyte-equivalent, CEPsh, we […]


Continue.. Astrocyte-like CEPsh glia respond to stress

Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease

Posted by klaurent Rockefeller

Kavli Affiliate: Charles Rice | Authors: Rachel Yamin, Kevin S Kao, Margaret R MacDonald, Tineke Cantaert, Charles M Rice, Jeffrey V Ravetch and Stylianos Bournazos | Summary: Abstract Although dengue virus (DENV) infection typically causes asymptomatic disease, DENV-infected patients can experience severe complications. A risk factor for symptomatic disease is pre-existing anti-DENV IgG antibodies. Cellular […]


Continue.. Human FcγRIIIa activation on splenic macrophages drives the in vivo pathogenesis of dengue disease

The molecular genetic landscape of human brain size variation

Posted by klaurent UCSD / Salk

Kavli Affiliate: Eric Courchesne | Authors: Jakob Seidlitz, Travis T. Mallard, Jacob W. Vogel, Younga H. Lee, Varun Warrier, Gareth Ball, Oskar Hansson, Leanna M. Hernandez, Ayan S. Mandal, Konrad Wagstyl, Michael V. Lombardo, Eric Courchesne, Joseph T. Glessner, Theodore D. Satterthwaite, Richard A.I. Bethlehem, Lifespan Brain Chart Consortium, Shinya Tasaki, Bernard Ng, Chris Gaiteri, […]


Continue.. The molecular genetic landscape of human brain size variation

An inhibitory plasticity mechanism for world structure inference by hippocampal replay

Posted by klaurent Columbia

Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Darian Hadjiabadi, Satoshi Terada, Ivan Soltesz and Attila Losonczy | Summary: Summary Memory consolidation assimilates recent experiences into long-term memory. This process requires the replay of learned sequences, though the content of these sequences remains controversial. Recent work has shown that the statistics of replay deviate from […]


Continue.. An inhibitory plasticity mechanism for world structure inference by hippocampal replay

A Biophysical Basis for Learning and Transmitting Sensory Predictions

Posted by klaurent Columbia

Kavli Affiliate: Larry Abbott, Nathaniel Sawtell | Authors: Salomon Zev Muller, Larry F Abbott and Nathaniel B Sawtell | Summary: Abstract Homeostatic (anti-Hebbian) forms of synaptic are effective at eliminating “prediction errors” that signal the differences between predicted and actual sensory input. However, such mechanisms appear to preclude the possibility of transmitting the resulting predictions […]


Continue.. A Biophysical Basis for Learning and Transmitting Sensory Predictions

Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles, Patrick Kanold | Authors: Calvin J Kersbergen, Travis A Babola, Patrick O Kanold and Dwight E Bergles | Summary: ABSTRACT Intrinsically generated neural activity propagates through the developing auditory system to promote maturation and refinement of sound processing circuits prior to hearing onset. This early patterned activity is induced by non-sensory […]


Continue.. Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

The BRAIN Initiative Cell Census Data Ecosystem: A User’s Guide

Posted by klaurent Hopkins

Kavli Affiliate: Michael Miller | Authors: BICCN Data Ecosytem Collaboration, Michael J Hawrylycz, Maryann E Martone, Patrick R Hof, Ed S Lein, Aviv Regev, Giorgio A. A Ascoli, Jan G Bjaalie, Hong-Wei Dong, Satrajit S Ghosh, Jesse Gillis, Ronna Hertzano, David R Haynor, Yongsoo Kim, Yufeng Liu, Jeremy A Miller, Partha P Mitra, Eran Mukamel, […]


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Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

Posted by klaurent NTNU

Kavli Affiliate: Vy Thuy Nguyen | Authors: Kim Vy Nguyen Ngoc, Somesh Sai, Yesl Jun, R. Hugh F. Bender, Vira Kravets, Han Zhu, Christopher J Hatch, Michael Schlichting, Roberto Gaetani, Medhavi Mallick, Stephanie J Hachey, Karen Christman, Steven Carl George, Christopher C Hughes and Maike Sander | Summary: Abstract Blood vessels play a critical role […]


Continue.. Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids