A Computational Model for Storing Memories in the Synaptic Structures of the Brain

Kavli Affiliate: Gabriel Silva | Authors: Vivek K George, Vikash N Morar and Gabriel A Silva | Summary: Abstract Spike-timing dependent plasticity (STDP) is widely accepted as a mechanism through which the brain can learn information from different stimuli. Basing synaptic changes on the timing between presynaptic and postsynaptic spikes enhances contributing edges within a […]


Continue.. A Computational Model for Storing Memories in the Synaptic Structures of the Brain

Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

Kavli Affiliate: Jose Suarez Lopez | Authors: Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales Ramirez, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia L. Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, […]


Continue.. Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

Kavli Affiliate: Robert Edwards | Authors: Frederic Bibollet-Ruche, Ronnie M Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N Skelly, Ryan S Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, Andrew Connell, Hui Li, Elena E Giorgi, Ge S Song, Shilei Ding, […]


Continue.. A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

Microscopic Imaging of Epigenetic Age

Kavli Affiliate: Tatyana Sharpee | Authors: Delany Rodriguez, Lorenzo Fiengo, Martin Alvarez-Kuglen, Haodong Qin, Chen Farhy, Aaron Havas, Rozalyn M Anderson, Peter D Adams, Tatyana O Sharpee and Alexey Terskikh | Summary: ABSTRACT Predictive biomarkers of functional or biological age are key for evaluating interventions aimed at increasing healthspan and / or lifespan in humans. […]


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A tissue injury repair pathway distinct but parallel to host pathogen defense

Kavli Affiliate: Daniel S. Mucida, Elaine Fuchs | Authors: Siqi Liu, Yun Ha Hur, Xin Cai, Qian Cong, Yihao Yang, Chiwei Xu, Angelina M Bilate, Kevin Andrew Uy Gonzales, Christopher J. Cowley, Brian Hurwitz, Ji-Dung Luo, Tiffany Tseng, Shiri Gur-Cohen, Megan Sribour, Tatiana Omelchenko, John Levorse, H Amalia Pasolli, Criag B Thompson, Daniel Mucida and […]


Continue.. A tissue injury repair pathway distinct but parallel to host pathogen defense

MLL1 regulates cytokine-driven cell migration and metastasis

Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Ludmila Danilova, Estibaliz Gómez-de-Mariscal, Dongjoo Kim, Rong Fan, Arrate Munoz-Barrutia, Elana J Fertig and Denis Wirtz | Summary: Abstract Cell migration is a critical requirement for cancer metastasis. Cytokine production and its role in cancer cell migration have been traditionally associated with immune cells in the […]


Continue.. MLL1 regulates cytokine-driven cell migration and metastasis

Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes

Kavli Affiliate: John Rubenstein | Authors: Siavash Fazel Darbandi, Joon-Yong An, Kenneth Lim, Nicholas F. Page, Lindsay Liang, Athena R. Ypsilanti, Eirene Markenscoff-Papadimitriou, Matthew W. State, Alex S. Nord, Stephan J. Sanders and John L. R. Rubenstein | Summary: Abstract The authors have withdrawn their manuscript because of uncertainty about an antibody reagent that was […]


Continue.. Autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes

Internal noise promotes heterogeneous synaptic dynamics important for working memory in recurrent neural networks

Kavli Affiliate: Terrence Sejnowski | Authors: Nuttida Rungratsameetaweemana, Robert Kim and Terrence Sejnowski | Summary: Abstract Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neurons perform cognitive tasks. Training such networks to perform tasks that require information maintenance over a brief period […]


Continue.. Internal noise promotes heterogeneous synaptic dynamics important for working memory in recurrent neural networks

DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-Analysis

Kavli Affiliate: Terrence Sejnowski | Authors: Antonio Pinto-Duarte, Katherine Bogue, Terrence J Sejnowski and Shyam Srinivasan | Summary: Abstract Epigenetic changes are involved in the onset and progression of cancer, and the detection of DNA methylation signatures may foster the improvement of diagnosis and prognosis. While the emergence of innovative technologies has fostered numerous studies […]


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Molecular programs of regional specification and neural stem cell fate progression in developing macaque telencephalon

Kavli Affiliate: Pasko Rakic, Nenad Sestan | Authors: Nicola Micali, Shaojie Ma, Mingfeng Li, Suel-Kee Kim, Xoel Mato-Blanco, Suvimal Sindhu, Jon I. Arellano, Tianliuyun Gao, Alvaro Duque, Gabriel Santpere, Nenad Sestan and Pasko Rakic | Summary: Abstract Early telencephalic development involves patterning of the distinct regions and fate specification of the neural stem cells (NSCs). […]


Continue.. Molecular programs of regional specification and neural stem cell fate progression in developing macaque telencephalon