The swan genome and transcriptome: its not all black and white

Kavli Affiliate: Erich Jarvis | Authors: Anjana C. Karawita, Yuanyuan Cheng, Keng Yih Chew, Arjun Challgula, Robert Kraus, Ralf C. Mueller, Marcus Z. W. Tong, Katina D. Hulme, Helle Beielefeldt-Ohmann, Lauren E. Steele, Melanie Wu, Julian DJ Sng, Ellesandra Noye, Timothy J. Bruxner, Gough G. Au, Suzanne Lowthe, Julie Blommaert, Alexander Suh, Alexander J. McCauley, […]


Continue.. The swan genome and transcriptome: its not all black and white

Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration

Kavli Affiliate: Karen Christman | Authors: Pamela Duran, Emma Zelus, Saya French, Lindsey Burnett, Karen Christman and Marianna Alperin | Summary: Objectives: Childbirth is a key risk factor for pelvic floor muscle (PFM) injury and dysfunction, and subsequent pelvic floor disorders (PFDs). Multiparity further exacerbates these risks. Using the pre-clinical rat model of simulated birth […]


Continue.. Repeated birth injuries lead to pelvic floor muscle dysfunction and impairment in regeneration

The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Kavli Affiliate: Michela Gallagher | Authors: Dong-Hee Kim, In-Beom Jin, Nam-Heon Kim, Yong-Jae Jeon, Bo-Ryoung Choi, Michela Gallagher and Jung-Soo Han | Summary: The lateral habenula (LHb) has been implicated in conditioned inhibition. Here, the modulating effects of LHb activity on the association of a conditioned stimulus (CS) with the nonoccurrence of an unconditioned stimulus […]


Continue.. The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict

Kavli Affiliate: Adam Aron | Authors: Pria L Daniel, James J Bonaiuto, Sven Bestmann, Adam R Aron and Simon Little | Summary: Flexibility of behavior and the ability to rapidly switch actions is critical for adaptive living in humans. It is well established that the right-inferior frontal gyrus (R-IFG) is recruited during outright action-stopping, relating […]


Continue.. High precision magnetoencephalography reveals increased right-inferior frontal gyrus beta power during response conflict

Altered basal ganglia output during self-restraint

Kavli Affiliate: Joshua Berke | Authors: Bon-Mi Gu and Joshua D. Berke | Summary: Suppressing actions is essential for flexible behavior. Multiple neural circuits involved in behavioral inhibition converge upon a key basal ganglia output nucleus, the substantia nigra pars reticulata (SNr). To examine how changes in basal ganglia output contribute to self-restraint, we recorded […]


Continue.. Altered basal ganglia output during self-restraint

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Kavli Affiliate: David Linden | Authors: J. Kopal, K. Kumar, K. Saltoun, C. Modenato, C. A. Moreau, S. Martin-Brevet, G. Huguet, M. Jean-Louis, C.O. Martin, Z. Saci, N. Younis, P. Tamer, E. Douard, A. M. Maillard, B. Rodriguez-Herreros, A. Pain, S. Richetin, 16p11.2 European Consortium, Simons Searchlight Consortium, L. Kushan, A. I. Silva, M. B. […]


Continue.. Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Flexible utilization of spatial- and motor-based codes for the storage of visuo-spatial information

Kavli Affiliate: John Serences | Authors: Margaret M. Henderson, Rosanne L. Rademaker and John T. Serences | Summary: Working memory provides flexible storage of information in service of upcoming behavioral goals. Some models propose specific fixed loci and mechanisms for the storage of visual information in working memory, such as sustained spiking in parietal and […]


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Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

Kavli Affiliate: Michael Miller, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Daniel Tward and Michael Miller | Summary: Reconstructing dense 3D anatomical coordinates from 2D projective measurements has become a central problem in both mouse and human digital pathology. We describe a new family of diffeomorphic mapping technologies called Projective LDDMM which generate diffeomorphic […]


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Parallel systems for social and spatial reasoning within the cortical apex

Kavli Affiliate: Winrich Freiwald | Authors: Ben Deen and Winrich A Freiwald | Summary: What is the cognitive and neural architecture for high-level reasoning? We hypothesize that systems for understanding people and places remain separate throughout the brain, but share a parallel organization. We test this hypothesis using deep neuroimaging of individual human brains on […]


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Ret loss-of-function decreases enteric neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

Kavli Affiliate: Loyal Goff | Authors: Elizabeth Vincent, Sumantra Chatterjee, Gabrielle H Cannon, Dallas Auer, Holly Ross, Aravinda Chakravarti and Loyal A Goff | Summary: The receptor tyrosine kinase gene RET plays a critical role in the fate specification of enteric neural crest-derived cells (ENCDCs) during enteric nervous system (ENS) development. Pathogenic RET loss of […]


Continue.. Ret loss-of-function decreases enteric neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development