Kavli Affiliate: Thomas P. Sakmar | Authors: Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk and Thomas P. Sakmar | Summary: Abstract Cholestatic itch is a severe and debilitating symptom in liver diseases with limited treatment options. The class A G protein-coupled […]
Kavli Affiliate: Daniel Kronauer | Authors: Lindsey E. Lopes, Erik T. Frank, Zsolt Kárpáti, Thomas Schmitt and Daniel J.C. Kronauer | Summary: Abstract Ants communicate via an arsenal of different pheromones produced in a variety of exocrine glands. For example, ants release alarm pheromones in response to danger to alert their nestmates and to trigger […]
Kavli Affiliate: Menno Witter, Asgeir Kobro-Flatmoen | Authors: Katrine Sjaastad Hanssen, Menno P. Witter, Axel Sandvig, Ioanna Sandvig and Asgeir Kobro-Flatmoen | Summary: Abstract Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part of the […]
Kavli Affiliate: Daniel Minor | Authors: Daniel L Minor, Jr., Zhou Chen and Abhisek Mondal | Summary: Abstract Gabapentinoid drugs for pain and anxiety act on the CaVα2δ-1 and CaVα2δ-2 subunits of high-voltage activated calcium channels (CaV1s and CaV2s). Here, we present the cryo-EM structure of the gabapentin-bound brain and cardiac CaV1.2/CaVβ3/CaVα2δ-1 channel. The data […]
Kavli Affiliate: Daniel Kronauer | Authors: Catalina Valdivia, Justin A. Newton, Sean O’Donnell, Christoph von Beeren, Daniel J. C Kronauer, Jacob A Russell and Piotr Lukasik | Summary: Abstract The transmission of microbial symbionts across individuals and generations can be critical for animal development and survival. Likewise, the transmission of microbes across closely interacting species […]
Kavli Affiliate: Joerg Bewersdorf | Authors: Ons M’Saad, Michael Shribak and Joerg Bewersdorf | Summary: Abstract The spatial resolution and contrast sensitivity of the human eye is limited, restricting our ability to directly see subcellular structures. We report a new principle for unaided eye cellular visualization in a method we call Unclearing Microscopy. By expanding […]
Kavli Affiliate: Patrick Kanold | Authors: Ji Liu, Kate Maximov and Patrick O Kanold | Summary: Abstract Many animal training paradigms rely on head-fixation. Head-fixation training is typically laborious and can benefit from automation to relieve the workload as well as to reduce the variability in the training outcome. Several groups have reported successful implementations […]
Kavli Affiliate: Vy Thuy Nguyen | Authors: Tino Pleiner, Masami Hazu, Giovani Pinton Tomaleri, Vy N. Nguyen, Kurt Januszyk and Rebecca M. Voorhees | Summary: SUMMARY Tail anchored proteins (TAs) play essential roles at both the ER and mitochondria, and their accurate localization is critical to proteostasis. Biophysical similarities lead to mistargeting of mitochondrial TAs […]
Kavli Affiliate: Bente Jacobsen, Menno Witter, Eirik Nilssen | Authors: Eirik S. Nilssen, Bente Jacobsen, Thanh P. Doan, Paulo J.B. Girao and Menno P. Witter | Summary: ABSTRACT Functionally distinct information encoded by the two main divisions of the entorhinal cortex (EC), the lateral EC (LEC) and the medial EC (MEC), is thought to be […]
Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip, Sammy Weiser Novak, Masaaki Kuwajima, Lyndsey Kirk, Uri Manor, Kristen M Harris and John H Reynolds | Summary: ABSTRACT Working memory relies critically on the dorsolateral prefrontal cortex (dlPFC). Morphology and function of the dlPFC, and corresponding working memory performance, are affected early in […]