Age-dependent changes in the dynamic functional organization of the brain at rest – a cross – cultural replication approach

Kavli Affiliate: David Linden | Authors: Xi Yang, Xinqi Zhou, Fei Xin, Benjamin Becker, David Linden and Dennis Hernaus | Summary: Abstract Age-associated changes in brain function play an important role in the development of neurodegenerative diseases. Although previous work has examined age-related changes in static functional connectivity (FC), accumulating evidence suggests that advancing age […]


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Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.

Kavli Affiliate: Jose Suarez Lopez | Authors: Pamela Alfaro-Vargas, Alisson Bastos-Salas, Rodrigo Muñoz-Arrieta, Reinaldo Pereira-Reyes, Mauricio Redondo-Solano, Julián Fernández, Aníbal Mora-Villalobos and José Pablo López-Gómez | Summary: Abstract Peptaibols (Paib), are a class of biologically active peptides isolated from soil, fungi and molds, which have interesting properties as antimicrobial agents. Paib production was optimized in […]


Continue.. Peptaibol Production and Characterization from Trichoderma asperellum and their Action as Biofungicide.

Alpha-synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinsons disease

Kavli Affiliate: Sreeganga Chandra | Authors: Eduardo Martin-Lopez, Charles A. GREER, Sreeganga Chandra, Vidyadhara D J, Teresa Liberia, Sarah J. Meller, Leah E. Harmon, Ryan M. Hsu, Kimberly Han and Betul Yucel | Summary: Abstract Parkinson’s Disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathological […]


Continue.. Alpha-synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinsons disease

Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest

Kavli Affiliate: Anders Dale | Authors: Aihua Lin, alexey shadrin, Dennis van der Meer, Guy Hindley, Weiqiu Cheng, Ida Elken Sonderby, Shahram Bahrami, Kevin S OConnell, Zillur Rahman, Nadine Parker, Olav B Smeland, Chun Fan, Dominic Holland, Anders Dale, Ole Andreassen and Oleksandr Frei | Summary: Abstract Motivation Genome-wide association studies (GWAS) have been successful […]


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Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

Kavli Affiliate: Kevin Bender | Authors: Selin Schamiloglu, Elinor Lewis, Anne C Hergarden, Kevin Bender and Jennifer L Whistler | Summary: ABSTRACT Second generation antipsychotics (SGAs) are front-line treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictability in treatment efficacy remain unclear. All […]


Continue.. Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

Internal states as a source of subject-dependent movement variability and their representation by large-scale networks

Kavli Affiliate: Kathleen Cullen & Sridevi Sarma | Authors: Macauley Smith Breault, Pierre Sacré, Zachary B Fitzgerald, John T Gale, Kathleen E Cullen, Jorge A González-Martínez and Sridevi V Sarma | Summary: Abstract A human’s ability to adapt and learn relies on reflecting on past performance. Such reflections form latent factors called internal states that […]


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A thermodynamically-consistent model for ATP production in mitochondria

Kavli Affiliate: Terrence Sejnowski | Authors: Guadalupe C. Garcia, Thomas M. Bartol, Jr., Terrence J. Sejnowski and Padmini Rangamani | Summary: Abstract Life is based on energy conversion. In the nervous system, in particular, significant amounts of energy are needed to maintain synaptic transmission and homeostasis. To a large extent, neurons depend on oxidative phosphorylation […]


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ATG9 vesicles comprise the seed membrane of mammalian autophagosomes

Kavli Affiliate: Pietro DeCamilli | Authors: Taryn J. Olivas, Yumei Wu, Shenliang Yu, Lin Luan, Peter Choi, Shanta Nag, Pietro De Camilli, Kallol Gupta and Thomas J. Melia | Summary: Abstract During autophagosome biogenesis, the incorporation of transmembrane proteins into the expanding phagophore is not readily observed. In addition, the membrane surface area of the […]


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From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement

Kavli Affiliate: Patricia Janak | Authors: Kurt Michael Fraser, Heather J Pribut, Patricia H Janak and Ronald Keiflin | Summary: Abstract Reward-seeking requires the coordination of motor programs to achieve goals. Midbrain dopamine neurons are critical for reinforcement and their activation is sufficient for learning about cues, actions, and outcomes. Here we examine in detail […]


Continue.. From Prediction to Action: Dissociable Roles of Ventral Tegmental Area and Substantia Nigra Dopamine Neurons in Instrumental Reinforcement

In silico discovery of repetitive elements as key sequence determinants of 3D genome folding

Kavli Affiliate: Michael Keiser | Authors: Laura M Gunsalus, Michael J. Keiser and Katherine S Pollard | Summary: Abstract Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome-wide. We developed an in silico deep-learning strategy to quantify the […]


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