Kavli Affiliate: Michael Goldberg | Authors: Mitchell R. Vollger, William S. DeWitt, Philip C. Dishuck, William T. Harvey, Xavi Guitart, Michael E. Goldberg, Allison Rozanski, Julian Lucas, Mobin Asri, The Human Pangenome Reference Consortium, Katherine M. Munson, Alexandra P. Lewis, Kendra Hoekzema, Glennis A. Logsdon, David Porubsky, Benedict Paten, Kelley Harris, PingHsun Hsieh and Evan […]
Kavli Affiliate: Robert Edwards | Authors: Pengcheng Zhang, David Rumschitzki and Robert H Edwards | Summary: During exocytosis, the fusion of secretory vesicle with plasma membrane forms a pore that regulates release of neurotransmitter and peptide. Heterogeneity of fusion pore behavior has been attributed to stochastic variation in a common exocytic mechanism, implying a lack […]
Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Nathaniel Douglass Daw and Daphna Shohamy | Summary: A key question in decision making is how humans arbitrate between competing learning and memory systems to maximize reward. We address this question by probing the balance between the effects, on choice, of incremental trial-and-error learning versus episodic memories […]
Kavli Affiliate: Menno Witter | Authors: Christiana Bjorkli, Nora Cecilie Ebbesen, Joshua B Julian, Menno P Witter, Axel Sandvig and Ioanna Sandvig | Summary: One of the neuropathological hallmarks of Alzheimer’s disease (AD) is the accumulation of amyloid-β (Aβ) plaques, which is preceded by intraneuronal build-up of toxic, aggregated Aβ during disease progression. Aβ plaques […]
Kavli Affiliate: Gabriel Silva | Authors: Bruna M. Silva, Flavio Protasio Veras, Giovanni Gomes, Seppe Cambier, Gabriel Silva, Andreza Quadros, Diego Caetite, Daniele Nascimento, Camila Silva, Juliana Silva, Samara Damasceno, Ayda Schneider, Fabio Beretta, Sabrina Batah, Icaro Castro, Isadora Paiva, Tamara Rodrigues, Ana C G Salina, Ronaldo Martins, Guilherme Cebinelli, Naira Bibo, Daniel Jorge, Helder […]
Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Eric G Keeler | Summary: Magic angle spinning NMR rotating frame relaxation measurements provide a powerful experimental strategy to probe biomolecules dynamics, as is illustrated by numerous recent applications. We discuss experimental strategies for this class of experiments, with a particular focus on systems where […]
Kavli Affiliate: Jean Laurent Casanova | Authors: Gaspard Kerner, Anna-Lena Neehus, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Guillaume Laval and Lluis Quintana-Murci | Summary: Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day […]
Kavli Affiliate: Dwight Bergles | Authors: Calvin J Kersbergen, Travis A Babola, Jason Rock and Dwight E Bergles | Summary: Neurons that process sensory information exhibit bursts of electrical activity during development, providing early training to circuits that will later encode similar features of the external world. In the mammalian auditory system, this intrinsically generated […]
Kavli Affiliate: Erich Jarvis | Authors: Gregory L Gedman, Matthew T Biegler, Bettina Haase, Morgan Wirthlin, Olivier Fedrigo, Andreas R Pfenning and Erich D Jarvis | Summary: Vocal learning is a skilled motor behavior observed in several mammalian and avian species and is critical for human speech. While convergent gene expression patterns have highlighted similar […]
Kavli Affiliate: Minoree Kohwi | Authors: Gillie Benchorin, Maggie Jiaqi Li, Richard Jangwon Cho, Yuxin Hu and Minoree Kohwi | Summary: Neural progenitors transit through multiple competence states that restrict production of each neural cell type. In Drosophila neuroblasts, a timed genome reorganization relocates the cell fate gene, hunchback, to the nuclear periphery, terminating competence […]