Microcephaly-associated WDR62 mutations hamper Golgi apparatus-to-spindle pole shuttling in human neural progenitors

Posted by klaurent Yale

Kavli Affiliate: Angeliki Louvi | Authors: Claudia dell’Amico, Marilyn Marlene Angulo Salavarria, Yutaka Takeo, Ichiko Saotome, Maria Teresa Dell’Anno, Maura Galimberti, Enrica Pellegrino, Elena Cattaneo, Angeliki Louvi and Marco Onorati | Summary: Abstract WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions during corticogenesis. Recessive mutations in WDR62 are associated with structural brain abnormalities […]


Continue.. Microcephaly-associated WDR62 mutations hamper Golgi apparatus-to-spindle pole shuttling in human neural progenitors

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Fei Li, Jacob Eriksen, Juan A Oses-Prieto, Yessica K Gomez, Hongfei Xu, Janet Finer-Moore, Phuong Nguyen, Alisa Bowen, Andrew Nelson, Alma Burlingame, Michael Grabe, Robert Stroud and Robert Edwards | Summary: Abstract Concentration of neurotransmitter inside synaptic vesicles (SVs) underlies the quantal nature of synaptic transmission. In contrast to […]


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Encoding of Dynamic Facial Information in the Middle Dorsal Face Area

Posted by klaurent Rockefeller

Kavli Affiliate: Winrich Freiwald | Authors: Zetian Yang and Winrich A. Freiwald | Summary: Abstract Faces in motion reveal a plethora of information through visual dynamics. Faces can move in complex patterns while transforming facial shape, e.g. during the generation of different emotional expressions. While motion and shape processing have been studied extensively in separate […]


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Neuronal Activity Alters Neuron to OPC Synapses

Posted by klaurent UCSF

Kavli Affiliate: Samuel Pleasure | Authors: Daniela S Moura, Alekhya Parvathaneni, Atehsa Sahagun, Hirofumi Noguchi, Iris Tilton, Emma Brennan, Robert M Brock, Lindsay R. Halladay, Samuel J Pleasure and Laura A. Cocas | Summary: Abstract The mechanisms that drive the timing and specificity of oligodendrocyte myelination during development, or remyelination after injury or immune attack […]


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Cortical surface electrical potentials are composed of multiple bandlimited frequency components, including high-gamma

Posted by klaurent UCSF

Kavli Affiliate: Kristofer Bouchard, Edward Chang | Authors: Jesse A Livezey, Ahyeon Hwang, Kseniya Usovich, Maximilian Dougherty, Edward F Chang and Kristofer E Bouchard | Summary: A common challenge in neuroscience is how to decompose noisy, multi-source signals measured in experiments into biophysically interpretable components. Analysis of cortical surface electrical potentials (CSEPs) measured using electrocorticography […]


Continue.. Cortical surface electrical potentials are composed of multiple bandlimited frequency components, including high-gamma

Oxytocin receptor is not required for social attachment in prairie voles

Posted by klaurent UCSF

Kavli Affiliate: Devanand Manoli | Authors: Kristen M. Berendzen, Ruchira Sharma, Maricruz Alvarado, YiChao Wei, Forrest D. Rogers, Adele Seelke, Trenton C. Simmons, Jessica Bond, Rose D. Larios, Michael Sherman, Srinivas Parthasarathy, Isidero Espineda, Joseph R. Knoedler, Annaliese Beery, Karen L. Bales, Nirao M Shah and Devanand S. Manoli | Summary: Prairie voles are among […]


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Suboptimal phenotypic reliability impedes reproducible human neuroscience

Posted by klaurent Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Aki Nikolaidis, Andrew An Chen, Xiaoning He, Russell Shinohara, Joshua Vogelstein, Michael Milham and Haochang Shou | Summary: Biomarkers of behavior and psychiatric illness for cognitive and clinical neuroscience remain out of reach. Suboptimal reliability of biological measurements, such as functional magnetic resonance imaging (fMRI), is increasingly cited as […]


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Versatile Multiple Object Tracking in Sparse 2D/3D Videos Via Diffeomorphic Image Registration

Posted by klaurent Columbia

Kavli Affiliate: Liam Paninski | Authors: James Yu, Amin Nejatbakhsh, Mahdi Torkashvand, Sahana Gangadharan, Maedeh Seyedolmohadesin, Jinmahn Kim, Liam Paninski and Vivek Venkatachalam | Summary: Tracking body parts in behaving animals, extracting fluorescence signals from cells embedded in deforming tissue, and analyzing cell migration patterns during development all require tracking objects with partially correlated motion. […]


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Dopamine Activates Astrocytes in Prefrontal Cortex via α1-Adrenergic Receptors

Posted by klaurent UCSF

Kavli Affiliate: Kira Poskanzer | Authors: Silvia Pittolo, Sae Yokoyama, Drew Willoughby, Charlotte Taylor, Michael Reitman, Vincent Tse, Zhaofa Wu, Roberto Etchenique, Yulong Li and Kira E Poskanzer | Summary: The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters and […]


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Distributional coding of associative learning within projection-defined populations of midbrain dopamine neurons

Posted by klaurent Columbia

Kavli Affiliate: Costa, Rui | Authors: Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill and Paul D Dodson | Summary: Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. While this teaching signal is […]


Continue.. Distributional coding of associative learning within projection-defined populations of midbrain dopamine neurons