Rotating Frame Relaxation for Magic Angle Spinning Solid State NMR, A Promising Tool for Characterizing Biopolymer Motion

Posted by klaurent Columbia

Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Eric G Keeler | Summary: Magic angle spinning NMR rotating frame relaxation measurements provide a powerful experimental strategy to probe biomolecules dynamics, as is illustrated by numerous recent applications. We discuss experimental strategies for this class of experiments, with a particular focus on systems where […]


Continue.. Rotating Frame Relaxation for Magic Angle Spinning Solid State NMR, A Promising Tool for Characterizing Biopolymer Motion

Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

Posted by klaurent Rockefeller

Kavli Affiliate: Jean Laurent Casanova | Authors: Gaspard Kerner, Anna-Lena Neehus, Laurent Abel, Jean-Laurent Casanova, Etienne Patin, Guillaume Laval and Lluis Quintana-Murci | Summary: Ancient genomics can directly detect human genetic adaptation to environmental cues. However, it remains unclear how pathogens have exerted selective pressures on human genome diversity across different epochs and affected present-day […]


Continue.. Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

Developmental spontaneous activity promotes sensory domains, frequency tuning and proper gain in central auditory circuits

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Calvin J Kersbergen, Travis A Babola, Jason Rock and Dwight E Bergles | Summary: Neurons that process sensory information exhibit bursts of electrical activity during development, providing early training to circuits that will later encode similar features of the external world. In the mammalian auditory system, this intrinsically generated […]


Continue.. Developmental spontaneous activity promotes sensory domains, frequency tuning and proper gain in central auditory circuits

Convergent gene expression highlights shared vocal motor microcircuitry in songbirds and humans

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Gregory L Gedman, Matthew T Biegler, Bettina Haase, Morgan Wirthlin, Olivier Fedrigo, Andreas R Pfenning and Erich D Jarvis | Summary: Vocal learning is a skilled motor behavior observed in several mammalian and avian species and is critical for human speech. While convergent gene expression patterns have highlighted similar […]


Continue.. Convergent gene expression highlights shared vocal motor microcircuitry in songbirds and humans

Nuclear architecture protein Distal antenna balances genome-binding and phase-separation properties to regulate neuroblast competence

Posted by klaurent Columbia

Kavli Affiliate: Minoree Kohwi | Authors: Gillie Benchorin, Maggie Jiaqi Li, Richard Jangwon Cho, Yuxin Hu and Minoree Kohwi | Summary: Neural progenitors transit through multiple competence states that restrict production of each neural cell type. In Drosophila neuroblasts, a timed genome reorganization relocates the cell fate gene, hunchback, to the nuclear periphery, terminating competence […]


Continue.. Nuclear architecture protein Distal antenna balances genome-binding and phase-separation properties to regulate neuroblast competence

High-resolution magic angle spinning NMR of KcsA in liposomes: the highly mobile C-terminus

Posted by klaurent Columbia

Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Gary Stanley Howarth II | Summary: The structure of the transmembrane domain of bacterial potassium channel KcsA has been extensively characterized, yet little information is available on the structure of its cytosolic N- and C-termini. This study presents high-resolution magic angle spinning (HR-MAS) and fractional […]


Continue.. High-resolution magic angle spinning NMR of KcsA in liposomes: the highly mobile C-terminus

Quantitative prediction and measurement of Piezo’s membrane footprint

Posted by klaurent Rockefeller

Kavli Affiliate: Roderick MacKinnon | Authors: Christoph A. Haselwandter, Roderick MacKinnon, Yusong Guo and Ziao Fu | Summary: Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape (Y. R. Guo, R. MacKinnon, 2017). The curved shape of the Piezo dome is expected to deform the surrounding lipid bilayer […]


Continue.. Quantitative prediction and measurement of Piezo’s membrane footprint

Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

Posted by klaurent Rockefeller

Kavli Affiliate: Erich Jarvis | Authors: Blair P Bentley, Tomás Carrasco-Valenzuela, Elisa K. S. Ramos, Harvinder Pawar, Larissa Souza Arantes, Alana Alexander, Shreya M Banerjee, Patrick Masterson, Martin Kuhlwilm, Martin Pippel, Jacquelyn Mountcastle, Bettina Haase, Marcela Uliano Silva, Giulio Formenti, Kerstin Howe, William Chow, Alan Tracey, Yumi Sims, Sarah Pelan, Jonathan Wood, Kelsey Yetsko, Justin […]


Continue.. Differential sensory and immune gene evolution in sea turtles with contrasting demographic and life histories

Global worming: massive invasion of North America by earthworms revealed

Posted by klaurent UCSD / Salk

Kavli Affiliate: John Reynolds | Authors: Jerome Mathieu, John Warren Reynolds, Carlos Fragoso and Elizabeth Hadly | Summary: Human activities cause major ecological changes by reshuffling the spatial distribution of species. The extent to which this process affects belowground biota is a critical issue because soil organisms play a key role in ecosystem functioning and […]


Continue.. Global worming: massive invasion of North America by earthworms revealed

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Sai Luo, Jun Zhang, Alex J.B. Kreutzberger, Amanda Eaton, Robert J. Edwards, Changbin Jing, Hai-Qiang Dai, Gregory D. Sempowski, Kenneth Cronin, Robert Parks, Adam Yongxin Ye, Katayoun Mansouri, Maggie Barr, Novalia Pishesha, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Anand Saminathan, Hanqin Peng, Himanshu Batra, Lorenza Bellusci, Surender Khurana, S. […]


Continue.. Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism