Kavli Affiliate: Fred Gage | Authors: W. Sharon Zheng, Yajun Zhang, Roger E. Zhu, Peng Zhang, Smriti Gupta, Limeng Huang, Deepika Sahoo, Kaiming Guo, Matthew E. Glover, Krishna C. Vadodaria, Mengyao Li, Tongrui Qian, Miao Jing, Jiesi Feng, Jinxia Wan, Philip M. Borden, Kaspar Podgorski, Farhan Ali, Alex C. Kwan, Li Gan, Li Lin, Fred […]
Kavli Affiliate: Stefano Fusi | Authors: Valeria Fascianelli, Fabio Stefanini, Satoshi Tsujimoto, Aldo Genovesio and Stefano Fusi | Summary: Abstract Animals likely use a variety of strategies to solve laboratory tasks. Traditionally, combined analysis of behavioral and neural recording data across subjects employing different strategies may obscure important signals and give confusing results. Hence it […]
Kavli Affiliate: Costa, Rui | Authors: Paul Botros, Nuria Vendrell-Llopis, Rui Costa and Jose Carmena | Summary: Abstract Throughout learning, refinement of cortical activity in cortex, a process termed “credit assignment”, underlies the refinement of behavioral actions leading to reward. While previous research shows striatum’s role in linking behavior to reward, striatum’s role in linking […]
Kavli Affiliate: Daniel Minor | Authors: Zhou Chen, Abhisek Mondal, Fayal Abderemane-Ali, Jose Montano, Balyn Zaro and Daniel L Minor, Jr. | Summary: Abstract Voltage-gated ion channels (VGICs) comprise multiple structural units whose assembly is required for function1,2. There is scant structural understanding of how VGIC subunits assemble and whether chaperone proteins are required. High-voltage […]
Kavli Affiliate: Alex Pollen | Authors: Kathleen C Keough, Sean Whalen, Fumitaka Inoue, Pawel F Przytycki, Tyler Fair, Chengyu Deng, Marilyn Steyert, Hane Ryu, Kerstin Lindblad-Toh, Elinor Karlsson, Zoonomia Consortium, Tomasz J. Nowakowski, Nadav J. Ahituv, Alex Aaron Pollen and Katherine S Pollard | Summary: Abstract Human Accelerated Regions (HARs) are conserved genomic loci that […]
Kavli Affiliate: Jeremiah Cohen | Authors: Jae Hyung Woo, Claudia G Aguirre, Bilal A Bari, Ken-Ichiro Tsutsui, Fabian Grabenhorst, Jeremiah Y Cohen, Wolfram Schultz, Alicia Izquierdo and Alireza Soltani | Summary: Abstract Despite being unpredictable and uncertain, reward environments often exhibit certain regularities, and animals navigating these environments try to detect and utilize such regularities […]
Kavli Affiliate: Michael Young | Authors: Morteza Zabihi, Daniel B. Rubin, Sophie E. Ack, Emily J. Gilmore, Valdery Moura Junior, Sahar F. Zafar, Quanzheng Li, Michael J. Young, Brian L. Edlow, Yelena G. Bodien and Eric S. Rosenthal | Summary: Abstract Accurately predicting emergence from disorders of consciousness (DoC) after acute brain injury can profoundly […]
Kavli Affiliate: Stanley Prusiner | Authors: Gregory E. Merz, Matthew J. Chalkley, Sophia Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado and Daniel R. Southworth | Summary: Abstract Neurodegenerative diseases (NDs) are characterized by the formation of amyloid filaments that adopt disease-specific conformations in the brain. Recently developed small […]
Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: Abstract NMDA receptor autoimmune encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause behavioral and neurologic deficits. Although many symptoms are responsive to immunotherapy, […]
Kavli Affiliate: Daniel S. Mucida | Authors: Leah A Gates, Bernardo Sgarbi Reis, Peder J Lund, Matthew R Paul, Marylene Leboeuf, Zara Nadeem, Thomas S Carroll, Benjamin Garcia, Daniel Mucida and C. David Allis | Summary: SUMMARY Posttranslational modifications (PTMs) on histone proteins are a key source of regulation on chromatin through impacting genome organization […]