Kavli Affiliate: Kathleen Cullen & Sridevi Sarma | Authors: Macauley Smith Breault, Pierre Sacré, Zachary B Fitzgerald, John T Gale, Kathleen E Cullen, Jorge A González-Martínez and Sridevi V Sarma | Summary: Abstract A human’s ability to adapt and learn relies on reflecting on past performance. Such reflections form latent factors called internal states that […]
Kavli Affiliate: Terrence Sejnowski | Authors: Guadalupe C. Garcia, Thomas M. Bartol, Jr., Terrence J. Sejnowski and Padmini Rangamani | Summary: Abstract Life is based on energy conversion. In the nervous system, in particular, significant amounts of energy are needed to maintain synaptic transmission and homeostasis. To a large extent, neurons depend on oxidative phosphorylation […]
Kavli Affiliate: Pietro DeCamilli | Authors: Taryn J. Olivas, Yumei Wu, Shenliang Yu, Lin Luan, Peter Choi, Shanta Nag, Pietro De Camilli, Kallol Gupta and Thomas J. Melia | Summary: Abstract During autophagosome biogenesis, the incorporation of transmembrane proteins into the expanding phagophore is not readily observed. In addition, the membrane surface area of the […]
Kavli Affiliate: Patricia Janak | Authors: Kurt Michael Fraser, Heather J Pribut, Patricia H Janak and Ronald Keiflin | Summary: Abstract Reward-seeking requires the coordination of motor programs to achieve goals. Midbrain dopamine neurons are critical for reinforcement and their activation is sufficient for learning about cues, actions, and outcomes. Here we examine in detail […]
Kavli Affiliate: Michael Keiser | Authors: Laura M Gunsalus, Michael J. Keiser and Katherine S Pollard | Summary: Abstract Natural and experimental genetic variants can modify DNA loops and insulating boundaries to tune transcription, but it is unknown how sequence perturbations affect chromatin organization genome-wide. We developed an in silico deep-learning strategy to quantify the […]
Kavli Affiliate: Terry Jernigan, Anders Dale | Authors: Diliana Pecheva, John R Iversen, Clare E Palmer, Richard Watts, Terry L Jernigan, Donald J Hagler and Anders M Dale | Summary: Abstract The Adolescent Brain and Cognitive Development (ABCD) study aims to measure the trajectories of brain, cognitive, and emotional development. Cognitive and behavioural development during […]
Kavli Affiliate: Jeffrey Friedman | Authors: Mihwa Choi, Marc Schneeberger, Wei Fan, Abhijit Bugde, Laurent Gautron, Kevin Vale, Yuan Zhang, Jeffrey M. Friedman, David J. Mangelsdorf and Steven A. Kliewer | Summary: SUMMARY Animals that consume fermenting fruit or nectar are exposed to ethanol, thus increasing their risk of injury or predation. This risk is […]
Kavli Affiliate: Jose Suarez Lopez | Authors: Munevver cinar, Lourdes Martinez-Medina, Pavan K Puvvula, Arsen Arakelyan, Badri N Vardarajan, Neil Anthony, Ganji P Nagaraju, Dongkyoo Park, Lei Feng, Faith Sheff, Marina Mosunjac, Debra Saxe, Steven Flygare, Olatunji B Alese, Jonathan Kaufman, Sagar Lonial, Juan Sarmiento, Izidore S. Lossos, Paula M Vertino, Jose A Lopez and […]
Kavli Affiliate: Roderick MacKinnon | Authors: George Vaisey, Priyam Banerjee, Alison J North, Christoph A Haselwandter and Roderick MacKinnon | Summary: Summary Piezo1 is the stretch activated Ca2+ channel in red blood cells that mediates homeostatic volume control. Here we study the organization of Piezo1 in red blood cells using a combination of super resolution […]
Kavli Affiliate: Wesley Thompson | Authors: Tzu-Hsuan Huang, Chun Chieh Fan, Wesley Thompson and Robert Loughnan | Summary: Abstract Magnetic resonance imaging (MRI) studies of the human brain are now attaining larger sample sizes with more diverse samples. However, population stratification, a key factor driving heterogeneity and confounding of associations, is seldom accounted for in […]