Orbitofrontal cortex populations are differentially recruited to support actions

Kavli Affiliate: Christina Gremel | Authors: Christian Cazares, Drew C. Schreiner, Mariela Lopez Valencia and Christina M. Gremel | Summary: Summary The ability to use information from one’s prior actions is necessary for decision-making. While Orbitofrontal cortex (OFC) has been hypothesized as key for inferences made using cue and value-related information, whether OFC populations contribute […]


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Protein Geometry, Function and Mutation

Kavli Affiliate: Robert Clark | Authors: Robert Clark Penner | Summary: Abstract This survey summarizes several works by the author on protein geometry and protein function with applications to viral glycoproteins in general and the spike glycoprotein of the SARS-CoV-2 virus in particular. Though a certain level of mathematical sophistication is assumed, the background biology […]


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Object representation in a gravitational reference frame

Kavli Affiliate: Kristina Nielsen and Charles Connor | Authors: Alexandriya MX Emonds, Ramanujan Srinath, Kristina J Nielsen and Charles E Connor | Summary: ABSTRACT When your head tilts laterally, as in sports, reaching, and resting, your eyes counterrotate less than 20%, and thus eye images rotate, over a total range of about 180°. Yet, the […]


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Mouse lemur transcriptomic atlas elucidates primate genes, physiology, disease, and evolution

Kavli Affiliate: Angela Wu | Authors: The Tabula Microcebus Consortium, Camille Ezran, Shixuan Liu, Jingsi Ming, Lisbeth A. Guethlein, Michael F. Z. Wang, Roozbeh Dehghannasiri, Julia Olivieri, Hannah K. Frank, Alexander Tarashansky, Winston Koh, Qiuyu Jing, Olga Botvinnik, Jane Antony, Stephen Chang, Angela Oliveira Pisco, Jim Karkanias, Can Yang, James E. Ferrell, Jr., Scott D. […]


Continue.. Mouse lemur transcriptomic atlas elucidates primate genes, physiology, disease, and evolution

Optogenetic control of RelA reveals effect of transcription factor dynamics on downstream gene expression

Kavli Affiliate: Hana El-Samad | Authors: Lindsey C Osimiri, Alain R Bonny, Seesha R Takagishi, Stefanie Luecke, Nina Riehs, Alexander Hoffmann and Hana El-Samad | Summary: Abstract Many transcription factors (TFs) translocate to the nucleus with varied dynamic patterns in response to different inputs. A notable example of such behavior is RelA, a subunit of […]


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Coordinated cadherin functions sculpt respiratory motor circuit connectivity

Kavli Affiliate: Xin Duan | Authors: Alicia N Vagnozzi, Matthew T Moore, Minshan Lin, Elyse M Brozost, Ritesh KC, Aambar Agarwal, Lindsay A Schwarz, Xin Duan, Niccolò Zampieri, Lynn T Landmesser and Polyxeni Philippidou | Summary: Abstract Breathing, and the motor circuits that control it, are essential for life. At the core of respiratory circuits […]


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Production of brain-derived neurotrophic factor gates plasticity in developing visual cortex

Kavli Affiliate: Michael Stryker | Authors: Megumi Kaneko and Michael P Stryker | Summary: Abstract We have previously shown that recovery of visual responses to a deprived eye during the critical period in mouse primary visual cortex (V1) requires both export of mRNA encoding brain derived neurotrophic factor (BDNF) to the dendrites of cortical cells […]


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Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters

Kavli Affiliate: Patricia Janak | Authors: Kurt M Fraser and Patricia H Janak | Summary: ABSTRACT Reward-seeking in the world is driven by cues that can have ambiguous predictive and motivational value. To produce adaptive, flexible reward-seeking it is necessary to exploit occasion setters, other distinct features in the environment, to resolve the ambiguity of […]


Continue.. Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters

Microcephaly-associated WDR62 mutations hamper Golgi apparatus-to-spindle pole shuttling in human neural progenitors

Kavli Affiliate: Angeliki Louvi | Authors: Claudia dell’Amico, Marilyn Marlene Angulo Salavarria, Yutaka Takeo, Ichiko Saotome, Maria Teresa Dell’Anno, Maura Galimberti, Enrica Pellegrino, Elena Cattaneo, Angeliki Louvi and Marco Onorati | Summary: Abstract WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions during corticogenesis. Recessive mutations in WDR62 are associated with structural brain abnormalities […]


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Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

Kavli Affiliate: Robert Edwards | Authors: Fei Li, Jacob Eriksen, Juan A Oses-Prieto, Yessica K Gomez, Hongfei Xu, Janet Finer-Moore, Phuong Nguyen, Alisa Bowen, Andrew Nelson, Alma Burlingame, Michael Grabe, Robert Stroud and Robert Edwards | Summary: Abstract Concentration of neurotransmitter inside synaptic vesicles (SVs) underlies the quantal nature of synaptic transmission. In contrast to […]


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