Kavli Affiliate: Reza Shadmehr | Authors: Mohammad Amin Fakharian, Alden Shoup, Paul Hage, Hisham Elseweifi and Reza Shadmehr | Summary: Null space theory predicts that a neuron will often generate spikes not to produce behavior, but to prevent another neuron’s impact on behavior. Here, we present a direct test of this theory in the brain. […]
Kavli Affiliate: Kathleen Cullen and Vikram Chib | Authors: Joonhee Leo Lee, Agostina Casamento-Moran, Amy J Bastian, Kathleen E Cullen and Vikram S. Chib | Summary: Goal-directed motor performance relies on the brain’s ability to distinguish between actions that lead to successful and unsuccessful outcomes. The basal ganglia (BG) and cerebellum (CBL) are integral to […]
Kavli Affiliate: Joshua Vogelstein | Authors: Eric W Bridgeford, Jaewon Chung, Robert J Anderson, Ali Mahzarnia, Jacques A Stout, Hae Sol Moon, Zay Yar Han, Joshua T Vogelstein and Alexandra Badea | Summary: Alzheimer’s disease (AD) lacks effective cures and is typically detected after substantial pathological changes have occurred, making intervention challenging. Early detection and […]
Kavli Affiliate: Seth Blackshaw | Authors: Krishna Singh, yang jin, Mingwen Hu, Isabella Pallazo, Marisol Cano,, Thanh Hoang, Imran Bhutto, Shusheng Wang, Debasish Sinha, Seth Blackshaw, Jiang Qian and James T. Handa | Summary: Environmental exposure such as cigarette smoke induces epigenetic changes that can induce degenerative heterogeneity and accelerate aging. In early age-related macular […]
Kavli Affiliate: Kathleen Cullen | Authors: Hannah R Martin, Brandie Morris Verdone, Omar Lopez-Ramirez, Merrill Green, Dana Silvian, Emily Scott, Kathleen E Cullen and Ruth Anne Eatock | Summary: Vestibular hair cells (HCs) faithfully and rapidly detect head motions and gravity, driving motor reflexes that stabilize balance and gaze during locomotion. With the transition from […]
Kavli Affiliate: Michael Miller | Authors: Daniel Sobrid-Camean, Bramwell Coulson, Michael Miller, Matthew CW Oswald, Tom Pettini, Richard A Baines and Matthias Landgraf | Summary: As developing networks transition from spontaneous irregular to patterned activity, they undergo plastic tuning phases, termed “critical periods”; “critical” because disturbances during these phases can lead to lasting changes in […]
Kavli Affiliate: Adam S. Charles and Richard Huganir | Authors: Zhining Chen, Gabrielle I. Coste, Evan Li, Richard L. Huganir, Austin R. Graves and Adam Charles | Summary: Synapses are submicron structures that connect and enable communication between neurons. Many forms of learning are thought to be encoded by synaptic plasticity, wherein the strength of […]
Kavli Affiliate: Alex Kolodkin | Authors: Sriram Sudarsanam, Luis Guzman-Clavel, Nyle Dar, Jakub Ziak, Naseer Shahid, Xinyu O Jin and Alex L Kolodkin | Summary: Cortical connectivity is contingent on ordered emergence of neuron subtypes followed by the formation of subtype-specific axon projections. Intracortical circuits, including long-range callosal projections, are crucial for information processing, but […]
Kavli Affiliate: John Rubenstein and Vikaas Sohal | Authors: Marc Turner, Sarah Robinson-Schwartz, Siavash Fazel Darbandi, John L.R. Rubenstein and Vikaas Singh Sohal | Summary: Disruptions in many genes linked to autism spectrum disorder (ASD) affect synaptic function and socioemotional behaviors in mice. However, exactly how synaptic dysfunction alters neural activity patterns underlying behavior remains […]
Kavli Affiliate: Michael Miller | Authors: Zifan Xie, Yong-Su Jin and Michael J Miller | Summary: Lacticaseibacillus rhamnosus GG (LGG) is one of the most studied probiotic strains and is widely used in both food and therapeutic industries. With its safe and health-beneficial properties, LGG is an ideal candidate for genome modification to enhance its […]