Context-dependent hyperactivity in syngap1a and syngap1b zebrafish autism models

Kavli Affiliate: Richard Huganir | Authors: Sureni H. Sumathipala, Suha Khan, Robert A. Kozol, Yoichi Araki, Sheyum Syed, Richard L. Huganir and Julia Dallman | Summary: Background and Aims SYNGAP1 disorder is a prevalent genetic form of Autism Spectrum Disorder and Intellectual Disability (ASD/ID) and is caused by de novo or inherited mutations in one […]


Continue.. Context-dependent hyperactivity in syngap1a and syngap1b zebrafish autism models

Serotonin predictively encodes value

Kavli Affiliate: Jeremiah Cohen | Authors: Emerson F Harkin, Cooper D Grossman, Jeremiah Y Cohen, Jean-Claude Béïque and Richard Naud | Summary: The in vivo responses of dorsal raphe nucleus (DRN) serotonin neurons to emotionally-salient stimuli are a puzzle. Existing theories centred on reward, surprise, or uncertainty individually account for some aspects of serotonergic activity […]


Continue.. Serotonin predictively encodes value

Motivation upregulates the adaptive response in sensorimotor learning

Kavli Affiliate: Vikram Chib | Authors: Salma Khatib, Vikram S. Chib and Firas Mawase | Summary: Motivational state plays a critical role in our ability to learn new motor skills; however, the mechanisms by which motivation influences motor learning are poorly understood. Using a motor learning paradigm in which motivation was varied in a trial-by-trial […]


Continue.. Motivation upregulates the adaptive response in sensorimotor learning

Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes

Kavli Affiliate: Michael Miller | Authors: Jamil Mahmud, Brittany W Geiler, Juthi Biswas, Michael J Miller, Julia E Myers, Stephen M Matthews, Amanda B Wass, Christine M O’Connor and Gary C Chan | Summary: Establishing a non-productive quiescent/silent infection within monocytes is essential for spread of human cytomegalovirus (HCMV). Yet, how HCMV establishes a quiescent […]


Continue.. Virion-associated US28 rapidly modulates Akt activity to suppress HCMV lytic replication in monocytes

The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Kavli Affiliate: Keri Martinowich | Authors: Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich and Stephanie C Hicks | Summary: Norepinephrine (NE) neurons in the locus […]


Continue.. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics

Costs of resistance limit the effectiveness of cooperation enforcement

Kavli Affiliate: Michael Miller | Authors: Michael E Miller, Susan Sidell and Elizabeth A Ostrowski | Summary: Cooperative groups are susceptible to invasion by cheaters that reap the benefits but fail to pay the costs. Both theory and experimental work have shown that cheating can select for counter-adaptations to resist cheating. But then why is […]


Continue.. Costs of resistance limit the effectiveness of cooperation enforcement

Effort cost of reaching prompts vigor reduction in older adults

Kavli Affiliate: Reza Shadmehr | Authors: Erik M. Summerside, Robert J Courter, Reza Shadmehr and Alaa A. Ahmed | Summary: As people age, they move slower. Is age-related reduction in vigor a reflection of a reduced valuation of reward by the brain, or a consequence of increased effort costs by the muscles? Here, we quantified […]


Continue.. Effort cost of reaching prompts vigor reduction in older adults

African elephants address one another with individually specific calls

Kavli Affiliate: Cynthia F. Moss | Authors: Michael A Pardo, Kurt Fristrup, David S Lolchuragi, Joyce Poole, Petter Granli, Cynthia Moss, Iain Douglas-Hamilton and George Wittemyer | Summary: Personal names are a universal feature of human language, yet few analogs exist in other species. While dolphins and parrots address conspecifics by imitating the calls of […]


Continue.. African elephants address one another with individually specific calls

Alignment of spatial transcriptomics data using diffeomorphic metric mapping

Kavli Affiliate: Justus M Kebschull, Michael Miller, Jean Fan | Authors: Kalen Clifton, Manjari Anant, Gohta Aihara, Lyla Atta, Osagie K Aimiuwu, Justus M Kebschull, Michael I Miller, Daniel Tward and Jean Fan | Summary: Spatial transcriptomics (ST) technologies enable high throughput gene expression characterization within thin tissue sections. However, comparing spatial observations across sections, […]


Continue.. Alignment of spatial transcriptomics data using diffeomorphic metric mapping

Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina

Kavli Affiliate: Seth Blackshaw | Authors: WPin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. HItchcock, Jiang Qian, David R. Hyde and Seth Blackshaw | Summary: Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes. This […]


Continue.. Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina