When no answer is better than a wrong answer: a causal perspective on batch effects

Kavli Affiliate: Brian Caffo Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Abstract Batch effects, undesirable sources of variability across multiple experiments, present significant challenges for scientific and clinical discoveries. Batch effects […]


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Multiplexing of temporal and spatial information in the lateral entorhinal cortex

Kavli Affiliate: James Knierim | Authors: Cheng Wang, Heekyung Lee, Geeta Rao and James J Knierim | Summary: Abstract Episodic memory involves the processing of spatial and temporal aspects of personal experiences. The lateral entorhinal cortex (LEC) plays an essential role in subserving memory. However, the specific mechanism by which LEC integrates spatial and temporal […]


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Structurally-informed human interactome reveals proteome-wide perturbations by disease mutations

Kavli Affiliate: Jin Kang | Authors: Dapeng Xiong, Yunguang Qiu, Junfei Zhao, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Mateo Torres, Weiqiang Lu, Siqi Liang, Jin Joo Kang, Charis Eng, Joseph Loscalzo, Feixiong Cheng and Haiyuan Yu | Summary: Abstract Human genome sequencing studies have identified numerous loci associated with complex diseases. However, translating human genetic […]


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Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD

Kavli Affiliate: Adam S. Charles | Authors: Augustine Xiaoran Yuan, Jennifer I Colonell, Anna Lebedeva, Michael Okun, Adam Charles and Timothy D Harris | Summary: Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. New advances in high density extracellular electrophysiology recording probes, […]


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Moving Beyond Processing and Analysis-Related Variation in Neuroscience

Kavli Affiliate: Joshua Vogelstein | Authors: Xinhui Li, Nathalia Bianchini Esper, Lei Ai, Steve Giavasis, Hecheng Jin, Eric Feczko, Ting Xu, Jon Clucas, Alexandre Franco, Anibal Solon Heinsfeld, Azeez Adebimpe, Joshua T. Vogelstein, Chao-Gan Yan, Oscar Esteban, Russell A. Poldrack, Cameron Craddock, Damien Fair, Theodore Satterthwaite, Gregory Kiar and Michael P. Milham | Summary: Abstract […]


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The lateral habenula integrates age and experience to promote social transitions in developing rats

Kavli Affiliate: Maya Opendak | Authors: Dana E Cobb-Lewis, Anne George, Shannon Hu, Katherine Packard, Mingyuan Song, Oliver Nguyen-Lopez, Emily Ikematsu Tesone, Jhanay Rowden, Julie Wang and Maya Opendak | Summary: Social behavior deficits are an early-emerging marker of psychopathology and are linked with early caregiving quality. However, the infant neural substrates linking early care […]


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Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation

Kavli Affiliate: Jeremias Sulam | Authors: Helge J Zollner, Christopher B. Davies-Jenkins, Dunja B. Simicic, Assaf Tal, Jeremias Sulam and Georg Oeltzschner | Summary: TPurpose The interest in applying and modeling dynamic MRS has recently grown. 2D modeling yields advantages for the precision of metabolite estimation in interrelated MRS data. However, it is unknown whether […]


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Recurrent connections enable point attractor dynamics and dimensionality reduction in a connectome-constrained model of the insect learning center

Kavli Affiliate: Grace Hwang and Kechen Zhang | Authors: Justin Joyce, Raphael Norman-Tenazas, Patricia Rivlin, Grace M. Hwang, Isaac Western, Kechen Zhang, William Gray-Roncal and Brian Robinson | Summary: The learning center in the insect, the mushroom body (MB) with its predominant population of Kenyon Cells (KCs), is a widely studied model system to investigate […]


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EEG responses to rapidly unfolding stochastic sounds reflect precision tracking

Kavli Affiliate: Mounya Elhilali | Authors: Sijia Zhao, Benjamin Skerritt-Davis, Mounya Elhilali, Frederic Dick and Maria Chait | Summary: The brain is increasingly viewed as a statistical learning machine, where our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changing expectations regarding the surrounding world. Which statistics does the […]


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A Causal Perspective for Batch Effects: When is no answer better than a wrong answer?

Kavli Affiliate: Brian Caffo and Joshua Vogelstein | Authors: Eric W. Bridgeford, Michael Powell, Gregory Kiar, Stephanie Noble, Jaewon Chung, Sambit Panda, Ross Lawrence, Ting Xu, Michael Milham, Brian Caffo and Joshua T. Vogelstein | Summary: Batch effects, undesirable sources of variance across multiple experiments, present significant challenges for scientific and clinical discoveries. Specifically, batch […]


Continue.. A Causal Perspective for Batch Effects: When is no answer better than a wrong answer?