3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

Kavli Affiliate: Denis Wirtz | Authors: Ashley L Kiemen, Cristina Almagro Perez, Valentina Matos Romero, André Forjaz, Alicia M Braxton, Lucie Dequiedt, Jeeun Parksong, Courtney D Cannon, Xuan Yuan, Sarah M Shin, Jaanvi Mahesh Babu, Elizabeth D Thompson, Toby C Cornish, Won Jin Ho, Laura D Wood, PeiHsun Wu, Arrate Munoz-Barrutia, Ralph H Hruban and […]


Continue.. 3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure

Hierarchical gradients of multiple timescales in the mammalian forebrain

Kavli Affiliate: Daeyeol Lee | Authors: Min Song, Eun Ju Shin, Hyojung Seo, Alireza Soltani, Nicholas A Steinmetz, Daeyeol Lee, Min Whan Jung and Se-Bum Paik | Summary: Many anatomical and physiological features of cortical circuits, ranging from the biophysical properties of synapses to the connectivity patterns among different neuron types, exhibit consistent variation along […]


Continue.. Hierarchical gradients of multiple timescales in the mammalian forebrain

Hydrophilic/ Omniphobic droplet arrays for high-throughput and quantitative enzymology

Kavli Affiliate: Michael Miller | Authors: Byungjin Lee, Fanny Sunden, Michael Miller, Bumshik Pak, Anke Krebber, Stefan Lutz and Polly M Fordyce | Summary: Engineered enzymes with enhanced or novel functions are specific catalysts with wide-ranging applications in industry and medicine. Here, we introduce Droplet Array Microfluidic Enzyme Kinetics (DA-MEK), a high-throughput enzyme screening platform […]


Continue.. Hydrophilic/ Omniphobic droplet arrays for high-throughput and quantitative enzymology

Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

Kavli Affiliate: Keri Martinowich | Authors: Genevieve E Craig, Lizbeth Ramos, Samuel R Essig, Nicholas J Eagles, Andrew E Jaffe, Keri Martinowich and Henry L Hallock | Summary: Deficits in attention are common across a range of neuropsychiatric disorders. A multitude of brain regions, including the frontal cortex (FC) and locus coeruleus (LC), have been […]


Continue.. Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

Decoding contextual influences on auditory perception from primary auditory cortex

Kavli Affiliate: Mounya Elhilali | Authors: Bernhard Englitz, Sahar Akram, Mounya Elhilali and Shihab Shamma | Summary: SPerception can be highly dependent on stimulus context, but whether and how sensory areas encode the context remains uncertain. We used an ambiguous auditory stimulus – a tritone pair – to investigate the neural activity associated with a […]


Continue.. Decoding contextual influences on auditory perception from primary auditory cortex

Mammalian D-Cysteine controls insulin secretion in the pancreas

Kavli Affiliate: Solomon Snyder | Authors: Robin Roychaudhuri, Timothy West, Soumyaroop Bhattacharya, Harry Saavedra, Lauren Albacarys, Moataz M Gadalla, Leon Mario Amzel, Peixin Yang and Solomon H. Snyder | Summary: D-amino acids are being recognized in mammals as important molecules with function. This is a first identification of endogenous D-cysteine in mammalian pancreas. D-cysteine is […]


Continue.. Mammalian D-Cysteine controls insulin secretion in the pancreas

The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Kavli Affiliate: Vikram Chib | Authors: Grace E Steward and Vikram S Chib | Summary: Feelings of cognitive fatigue emerge through repeated mental exertion and are ubiquitous in our daily lives. However, there is a limited understanding of the neurobiological mechanisms underlying the influence of cognitive fatigue on decisions to exert. We use functional magnetic […]


Continue.. The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice

Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. Resistance to age-related hearing loss in the echolocating big brown bat (Eptesicus fuscus)

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Kavli Affiliate: Denis Wirtz | Authors: Wenxuan Du, Bryan Zhou, André Forjaz, Sarah M. Shin, Fan Wu, Ashleigh J. Crawford, Praful R. Nair, Adrian C. Johnston, Hoku West-Foyle, Ashley Tang, Dongjoo Kim, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu, Jude M. Phillip, Won Jin Ho, David E. Sanin and Denis Wirtz | Summary: Enrichment of […]


Continue.. High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

Mobius Assembly for Plant Systems uncovers combinatorial interactions among promoters, coding sequences, and terminators in gene regulation

Kavli Affiliate: Andreas Andreou | Authors: Elif Gediz Kocaoglan, Andreas Andreou, Jessica Nirkko, Marisol Ochoa-Villarreal, Gary Loake and Naomi Nakayama | Summary: Plants are the primary biological platforms for producing food, energy, and materials in agriculture; however, they are largely untouched by synthetic biology-driven transformation in bioproduction technologies. Molecular tools for complex, multigene engineering are […]


Continue.. Mobius Assembly for Plant Systems uncovers combinatorial interactions among promoters, coding sequences, and terminators in gene regulation