Kavli Affiliate: Costa, Rui | Authors: Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill and Paul D Dodson | Summary: Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. While this teaching signal is […]
Kavli Affiliate: Michael Goldberg | Authors: Mitchell R. Vollger, William S. DeWitt, Philip C. Dishuck, William T. Harvey, Xavi Guitart, Michael E. Goldberg, Allison Rozanski, Julian Lucas, Mobin Asri, The Human Pangenome Reference Consortium, Katherine M. Munson, Alexandra P. Lewis, Kendra Hoekzema, Glennis A. Logsdon, David Porubsky, Benedict Paten, Kelley Harris, PingHsun Hsieh and Evan […]
Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Nathaniel Douglass Daw and Daphna Shohamy | Summary: A key question in decision making is how humans arbitrate between competing learning and memory systems to maximize reward. We address this question by probing the balance between the effects, on choice, of incremental trial-and-error learning versus episodic memories […]
Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Eric G Keeler | Summary: Magic angle spinning NMR rotating frame relaxation measurements provide a powerful experimental strategy to probe biomolecules dynamics, as is illustrated by numerous recent applications. We discuss experimental strategies for this class of experiments, with a particular focus on systems where […]
Kavli Affiliate: Minoree Kohwi | Authors: Gillie Benchorin, Maggie Jiaqi Li, Richard Jangwon Cho, Yuxin Hu and Minoree Kohwi | Summary: Neural progenitors transit through multiple competence states that restrict production of each neural cell type. In Drosophila neuroblasts, a timed genome reorganization relocates the cell fate gene, hunchback, to the nuclear periphery, terminating competence […]
Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Gary Stanley Howarth II | Summary: The structure of the transmembrane domain of bacterial potassium channel KcsA has been extensively characterized, yet little information is available on the structure of its cytosolic N- and C-termini. This study presents high-resolution magic angle spinning (HR-MAS) and fractional […]
Kavli Affiliate: Kenneth Miller | Authors: Shen Wang, Agostina Palmigiano, Kenneth D Miller and Stephen David Van Hooser | Summary: Cross-orientation suppression is a classic form of contextual normalization in visual cortex, yet the degree to which cortical circuits participate in the normalization computation is unclear. We visualized orientation maps of individual ferrets, and provided […]
Kavli Affiliate: Nathaniel Sawtell | Authors: Avner Wallach and Nathaniel B Sawtell | Summary: Nervous systems are hypothesized to learn and store internal models that predict the sensory consequences of motor actions. However, little is known about the neural mechanisms for generating accurate predictions under real-world conditions in which the sensory consequences of action depend […]
Kavli Affiliate: Costa, Rui | Authors: Claire L Warriner, Samaher Fageiry, Shreya Saxena, Rui M Costa and Andrew Miri | Summary: During limb movement, spinal circuits facilitate the alternating activation of antagonistic flexor and extensor muscles. Yet antagonist cocontraction is often required to stabilize joints, like when loads are handled. Previous results suggest that these […]
Kavli Affiliate: Robert Hawkins | Authors: Sreejan Kumar, Theodore R. Sumers, Takateru Yamakoshi, Ariel Goldstein, Uri Hasson, Kenneth A. Norman, Thomas L. Griffiths, Robert D. Hawkins and Samuel A. Nastase | Summary: Piecing together the meaning of a narrative requires understanding not only the individual words but also the intricate relationships between them. How does […]